pS45-CTNNB1 T41I

Stable Identifier
R-HSA-4839612
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Catenin beta-1, CTNB1_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
12101426 Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Taniguchi, K, Roberts, LR, Aderca, IN, Dong, X, Qian, C, Murphy, LM, Nagorney, DM, Burgart, LJ, Roche, PC, Smith, DI, Ross, JA, Liu, W

Oncogene 2002
10700176 AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Satoh, S, Daigo, Y, Furukawa, Y, Kato, T, Miwa, N, Nishiwaki, T, Kawasoe, T, Ishiguro, H, Fujita, M, Tokino, T, Sasaki, Y, Imaoka, S, Murata, M, Shimano, T, Yamaoka, Y, Nakamura, Y

Nat. Genet. 2000
12439748 Abnormalities of the APC/beta-catenin pathway in endometrial cancer

Moreno-Bueno, G, Hardisson, D, Sánchez, C, Sarrio, D, Cassia, R, García-Rostán, G, Prat, J, Guo, M, Herman, JG, Matías-Guiu, X, Esteller, M, Palacios, J

Oncogene 2002
External Reference Information
External Reference
UniProt:P35222 CTNNB1
Gene Names
CTNNB1, CTNNB, OK/SW-cl.35, PRO2286
Chain
initiator methionine:1, chain:2-781
Reference Genes
BioGPS Gene:1499 CTNNB1
COSMIC (genes):CTNNB1 CTNNB1
CTD Gene:1499 CTNNB1
dbSNP Gene:1499 CTNNB1
ENSEMBL:ENSG00000168036 CTNNB1
ENSEMBL:ENSG00000168036 CTNNB1
HGNC:2514 CTNNB1
KEGG Gene (Homo sapiens):hsa:1499 CTNNB1
Monarch:1499 CTNNB1
NCBI Gene:1499 CTNNB1
OMIM:116806 CTNNB1
UCSC:P35222 CTNNB1
Reference Transcript
Other Identifiers
0001990132
108
11722167_s_at
11747387_a_at
11747388_x_at
11748952_x_at
11749021_s_at
11749022_x_at
11750680_x_at
1499
1554411_at
16939558
1950
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
201533_at
2618941
2618942
2618945
2618955
2618957
2618958
2618959
2618960
2618961
2618962
2618965
2618967
2618969
2618971
2618973
2618975
2618978
2618980
2618981
2618982
2618983
29159
29160
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
40777_at
4DJS
8079021
A0A024R2Q3
A_14_P106050
A_14_P131897
A_23_P29495
A_23_P29499
A_33_P3421695
AAG35511
AAH58926
AAL89457
AAR18817
AB062292
AC104307
AF130085
AK289932
AY081165
AY463360
B4DGU4
BAB93475
BAF82621
BC058926
C9IZ65
CAA61107
CAA79497
CAB000108
CAB001950
CCDS2694
CH471055
CTNNB1
CTNNB1-201
CTNNB1-202
CTNNB1-203
CTNNB1-204
EAW64625
EAW64626
EAW64627
EAW64628
ENSG00000168036
ENSP00000344456
ENSP00000379486
ENSP00000379488
ENSP00000385604
ENST00000349496
ENST00000396183
ENST00000396185
ENST00000405570
EntrezGene:1499
g4503130_3p_at
GO:0000228
GO:0000278
GO:0000902
GO:0000922
GO:0000988
GO:0001085
GO:0001102
GO:0001569
GO:0001837
GO:0002052
GO:0003674
GO:0003682
GO:0003713
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005719
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005913
GO:0005925
GO:0005938
GO:0006351
GO:0006355
GO:0006464
GO:0006790
GO:0006810
GO:0007010
GO:0007049
GO:0007059
GO:0007155
GO:0007165
GO:0007223
GO:0007267
GO:0007399
GO:0008022
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0009790
GO:0010718
GO:0010909
GO:0016020
GO:0016055
GO:0016323
GO:0016328
GO:0016342
GO:0016525
GO:0019827
GO:0019899
GO:0019900
GO:0019903
GO:0022607
GO:0030054
GO:0030154
GO:0030331
GO:0030521
GO:0030877
GO:0030997
GO:0032355
GO:0032481
GO:0032991
GO:0032993
GO:0033234
GO:0034330
GO:0034333
GO:0034394
GO:0034641
GO:0035257
GO:0035315
GO:0035635
GO:0036023
GO:0040007
GO:0042493
GO:0042995
GO:0043065
GO:0043226
GO:0043525
GO:0044281
GO:0044325
GO:0044334
GO:0044336
GO:0044403
GO:0045202
GO:0045294
GO:0045296
GO:0045765
GO:0045892
GO:0045893
GO:0045944
GO:0045976
GO:0046332
GO:0048145
GO:0048471
GO:0048646
GO:0048660
GO:0048856
GO:0050681
GO:0050767
GO:0051091
GO:0051149
GO:0051276
GO:0051571
GO:0060070
GO:0061154
GO:0061324
GO:0061549
GO:0065003
GO:0070062
GO:0070369
GO:0070411
GO:0070602
GO:0071363
GO:0071681
GO:0071944
GO:0072182
GO:0090279
GO:0098609
GO:1904798
GO:1904837
GO:1904886
GO:1904948
GO:1904954
GO:1990138
GO:1990907
GO:1990909
GO:2000008
GO:2000144
HGNC:2514
HPA029159
HPA029160
Hs2.171271.2.S1_3p_s_at
ILMN_1651617
ILMN_1746396
ILMN_1757350
IPR000225
IPR011989
IPR013284
IPR016024
MIM:114500
MIM:114550
MIM:116806
MIM:132600
MIM:155255
MIM:167000
MIM:615075
MIM:617572
NM_001098209
NM_001098210
NM_001904
NP_001091679
NP_001091680
NP_001895
PF00514
PH_hs_0024820
PR01869
SM00185
uc003ckp.3
uc003ckr.3
uc010hia.2
UPI000012862F
X87838
X87838_at
Z19054
Participant Of
hasCandidate
Other forms of this molecule
CTNNB1 S45F [cytosol]
CTNNB1 S45P [cytosol]
pT41,S45-CTNNB1 S37F [cytosol]
pT41,S45-CTNNB1 S37A [cytosol]
pT41,S45-CTNNB1 S37C [cytosol]
pS37,T41,S45-CTNNB1 S33C [cytosol]
pS37,T41,S45-CTNNB1 S33F [cytosol]
pS37,T41,S45-CTNNB1 S33P [cytosol]
pS37,T41,S45-CTNNB1 S33Y [cytosol]
pS45-CTNNB1 T41A [cytosol]
Ub-K,p-Y-CTNNB1 [cytosol]
p-Y-CTNNB1 [cytosol]
p-S552-CTNNB1 [nucleoplasm]
p-S552-CTNNB1 [cytosol]
CTNNB1(116-376) [cytosol]
CTNNB1(1-115) [cytosol]
CTNNB1 [plasma membrane]
p-S45 CTNNB1 [cytosol]
p-T41,S45 CTNNB1 [cytosol]
p-S37,T41,S45, CTNNB1 [cytosol]
p-S33,S37,T41,S45 CTNNB1 [cytosol]
CTNNB1 [cytosol]
CTNNB1 [nucleoplasm]
Modified Residues
Name
L-threonine 41 replaced with L-isoleucine
Coordinate
41
PsiMod HEY
L-isoleucine residue [MOD:00019]
A protein modification that effectively converts a source amino acid residue to an L-isoleucine.
L-threonine removal [MOD:01647]
A protein modification that effectively removes or replaces an L-threonine.
Name
O-phospho-L-serine at 45
Coordinate
45
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
hepatocellular carcinoma 684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
endometrial cancer 1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
cancer 162 malignant tumor, malignant neoplasm, primary cancer
pituitary cancer 1785 malignant Pituitary neoplasm, pituitary gland cancer, neoplasm of pituitary gland (disorder), Pituitary gland neoplasm, malignant tumor of pituitary gland (disorder), pituitary neoplasm
Cross References
RefSeq
COSMIC
GeneCards
ZINC - Substances
ZINC target
PRO
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
PDB
Interactors (85)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9NQB0 TCF7L2  4 0.967 25
 UniProt:P12830 CDH1  10 0.951 15
 UniProt:P49841 GSK3B  4 0.95 19
 UniProt:P25054 APC  13 0.949 17
 UniProt:O15169 AXIN1  11 0.94 44
 UniProt:P15884 TCF4  1 0.94 22
 UniProt:Q9Y297 BTRC  2 0.926 8
 UniProt:Q9NSA3 CTNNBIP1  1 0.917 12
 UniProt:P10275 AR  4 0.891 15
 UniProt:P19022 CDH2  3 0.887 8
 UniProt:P46937 YAP1  7 0.881 14
 UniProt:Q9UJU2 LEF1  2 0.858 9
 UniProt:P33151 CDH5  2 0.815 6
 UniProt:P36402 TCF7  1 0.779 4
 UniProt:P35221 CTNNA1  2 0.758 4
 UniProt:Q9UKB1 FBXW11  1 0.723 4
 UniProt:P63208 SKP1  2 0.713 3
 UniProt:Q5JTC6 AMER1  3 0.711 9
 UniProt:O43707 ACTN4  3 0.696 7
 UniProt:O35625 Axin1  3 0.688 4
 UniProt:Q96AC1 FERMT2  1 0.681 13
 UniProt:Q08050 FOXM1  3 0.672 16
 UniProt:P14923 JUP  5 0.669 3
 UniProt:P19838 NFKB1  8 0.667 3
 UniProt:Q01826 SATB1  5 0.66 9
 UniProt:Q13761 RUNX3  7 0.656 12
 UniProt:P55197 AF10      0.656 5
 UniProt:O00482-1 NR5A2  1 0.65 5
 UniProt:Q9GZV5 WWTR1  3 0.641 4
 UniProt:P26358 DNMT1  2 0.628 8
 UniProt:Q6P1J9 CDC73  1 0.616 9
 UniProt:Q9YGY0 AXIN1      0.609 2
 UniProt:P08575 PTPRC  2 0.609 2
 UniProt:P23470 PTPRG      0.609 2
 UniProt:Q12913 PTPRJ  2 0.609 2
 UniProt:Q9GZQ8 MAP1LC3B  3 0.602 5
 UniProt:P49023 PXN  4 0.602 4
 UniProt:P49789 FHIT      0.602 4
 UniProt:P18012 IPAC      0.602 4
 UniProt:P50402 EMD  1 0.591 3
 UniProt:Q8TEW0 PARD3  3 0.589 2
 UniProt:Q04206 RELA  6 0.589 3
 UniProt:P11362 FGFR1  8 0.589 2
 UniProt:Q13308 PTK7      0.581 5
 UniProt:Q9BZE0 GLIS2      0.581 6
 UniProt:Q13625 TP53BP2  1 0.576 5
 IntAct:EBI-4399559 UBIQ      0.576 3
 UniProt:O75564 JERKY      0.576 3
 UniProt:Q92793 CREBBP  2 0.573 2
 UniProt:P33724  5 0.571 5
 UniProt:P11388 TOP2A  3 0.57 5
 UniProt:Q99697 PITX2  1 0.564 2
 UniProt:Q8TEK3 DOT1L  1 0.564 3
 UniProt:Q9Y2T1 AXIN2  4 0.564 2
 UniProt:P16284 PECAM1  4 0.564 3
 UniProt:P12931 SRC  4 0.544 2
 UniProt:P00519 ABL1  5 0.544 2
 UniProt:Q03431 PTH1R  1 0.543 4
 UniProt:Q9NYF0 DACT1  1 0.537 3
 IntAct:EBI-5237192 AXIN2      0.527 2
 UniProt:P09803 Cdh1  1 0.527 3
 UniProt:Q9EPK5 Wwtr1  4 0.525 2
 UniProt:Q9UKE5 TNIK  1 0.525 3
 UniProt:P02511 CRYAB  1 0.524 3
 UniProt:A1Z199 A1Z199      0.524 2
 UniProt:P14618-1 PKM  1 0.524 3
 UniProt:Q9JHQ5  1 0.524 2
 UniProt:P29474 NOS3  7 0.524 4
 UniProt:P14618 PKM  3 0.524 4
 UniProt:O14746 TERT  1 0.524 2
 UniProt:Q15599 NHRF2      0.508 2
 UniProt:O00512 BCL9  1 0.508 2
 UniProt:P08069 IGF1R  3 0.499 3
 IntAct:EBI-6668710 TCF      0.499 3
 UniProt:P18146 EGR1  1 0.499 7
 UniProt:Q9H6I2 SOX17  1 0.499 2
 UniProt:Q92597 NDRG1  1 0.499 3
 UniProt:P49757 NUMB  1 0.499 2
 UniProt:Q9Y265 RUVBL1  1 0.499 3
 UniProt:Q14160 SCRIB  1 0.463 2
 UniProt:P46940 IQGAP1  3 0.463 3
 UniProt:Q14526 HIC1  2 0.463 2
 UniProt:O95071 UBR5      0.463 6
 UniProt:P11279 LAMP1  3 0.462 2
 UniProt:Q99593 TBX5  1 0.462 3