Reactome | p-T611,S730,S739-FOXM1 [nucleoplasm]

p-T611,S730,S739-FOXM1 [nucleoplasm]

Stable Identifier

R-HSA-4088133

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08050 FOXM1

Gene Names

FOXM1, FKHL16, HFH11, MPP2, WIN

Chain

chain:1-763

Reference Genes

BioGPS Gene:2305 FOXM1

COSMIC (genes):FOXM1 FOXM1

CTD Gene:2305 FOXM1

dbSNP Gene:2305 FOXM1

ENSEMBL:ENSG00000111206.13 FOXM1

HGNC:3818 FOXM1

KEGG Gene (Homo sapiens):2305 FOXM1

Monarch:2305 FOXM1

NCBI Gene:2305 FOXM1

OMIM:602341 FOXM1

UCSC:Q08050 FOXM1

Reference Transcript

Other Identifiers

11725441_a_at

11725442_a_at

11734028_a_at

16760048

202580_PM_x_at

202580_x_at

2305

3440599

3440600

3440601

3440602

3440603

3440604

3440605

3440606

3440607

3440608

3440609

3440610

3440612

3440616

3440618

3440623

3440627

3440630

3440631

3440632

3440633

3440634

3440635

34715_at

7960340

A_23_P151150

GE59391

GO:0000086

GO:0000122

GO:0000278

GO:0000785

GO:0000977

GO:0000981

GO:0001558

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0006978

GO:0007049

GO:0008284

GO:0019901

GO:0023052

GO:0032873

GO:0042127

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0045944

GO:0046578

GO:0051726

GO:0140110

GO:2000377

GO:2000781

HMNXSV003023971

ILMN_1716400

ILMN_2344971

PH_hs_0026679

TC12001106.hg

U74612_at

g11386144_3p_s_at

Participates

as a component of

as an input of

as an output of

PLK1 phosphorylates FOXM1 (Homo sapiens)

Other forms of this molecule

p-T611-FOXM1 [nucleoplasm]

FOXM1 [nucleoplasm]

Inferred To

phospho-FOXM1 [nucleoplasm] (Bos taurus)

phospho-FOXM1 [nucleoplasm] (Gallus gallus)

phospho-FOXM1 [nucleoplasm] (Sus scrofa)

phospho-foxm1 [nucleoplasm] (Xenopus tropicalis)

phospho-p-T611,S730,S739-FOXM1 [nucleoplasm] (Canis familiaris)

phospho-p-T611,S730,S739-FOXM1 [nucleoplasm] (Danio rerio)

phospho-Foxm1 [nucleoplasm] (Mus musculus)

phospho-Foxm1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 611

Coordinate

611

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 730

Coordinate

730

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 739

Coordinate

739

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001230018.1, NP_068772.2, NP_973731.1, NP_973732.1, NP_001230017.1

OpenTargets

ENSG00000111206

GeneCards

Q08050

HPA

ENSG00000111206-FOXM1

Ensembl

ENST00000342628, ENSP00000354492, ENSG00000111206, ENSP00000352901, ENST00000361953, ENST00000359843, ENSP00000342307

PRO

Q08050

Pharos - Targets

Q08050

PDB

7FJ2, 3G73

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.672	16
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.612	7
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q8N9N5-7 BANP			0.556	3
UniProt:A0A455ZAR2 PNT87			0.556	4
UniProt:P24864 CCNE1	3	Unfolded CCNE1 [cytosol] (R-HSA-6813836) CCNE1 [cytosol] (R-HSA-157443) CCNE1 [nucleoplasm] (R-HSA-68363)	0.544	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.499	2
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.499	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.499	2
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.499	2

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