TCF7L2 K485fs25*

Stable Identifier
R-HSA-5334040
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Cuilliere-Dartigues, P, El-Bchiri, J, Krimi, A, Buhard, O, Fontanges, P, Fléjou, JF, Hamelin, R, Duval, A

Oncogene 2006
10919662 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

Duval, A, Rolland, S, Tubacher, E, Bui, H, Thomas, G, Hamelin, R

Cancer Res. 2000
External Reference Information
External Reference
UniProt:Q9NQB0 TCF7L2
Gene Names
TCF7L2, TCF4
Chain
chain:1-619
Reference Genes
BioGPS Gene:6934 TCF7L2
COSMIC (genes):TCF7L2 TCF7L2
CTD Gene:6934 TCF7L2
dbSNP Gene:6934 TCF7L2
ENSEMBL:ENSG00000148737 TCF7L2
ENSEMBL:ENSG00000148737 TCF7L2
HGNC:11641 TCF7L2
KEGG Gene (Homo sapiens):hsa:6934 TCF7L2
Monarch:6934 TCF7L2
NCBI Gene:6934 TCF7L2
OMIM:602228 TCF7L2
UCSC:Q9NQB0 TCF7L2
Reference Transcript
Other Identifiers
11746313_a_at
11746314_s_at
11746315_x_at
11746404_a_at
11747829_x_at
11751102_x_at
11755181_a_at
13535
16709333
1JDH
1JPW
212759_s_at
212761_at
212762_s_at
216035_x_at
216037_x_at
216511_s_at
2GL7
32025_at
3264622
3264623
3264624
3264626
3264627
3264633
3264652
3264659
3264685
3264689
3264692
3264696
3264697
3264698
3264699
3264708
3264710
3264712
3264714
3264722
3264723
3264724
3264725
3264726
38800
48528_at
6934
7930537
A0A0A0MTL7
A0A0D9SGH8
A0A1B0GU84
A0A1B0GUV5
A0A1B0GVE1
A_14_P125103
A_14_P133398
A_23_P127013
A_23_P389588
A_24_P921823
A_33_P3377304
AAH32656
AB034691
AB440195
ACI28525
ACI28527
ACI28530
ADK35175
ADK35178
ADK35180
ADK35181
ADK35182
ADK35184
ADK35185
ADK35187
AJ270770
AJ270771
AJ270772
AJ270773
AJ270774
AJ270775
AJ270776
AJ270777
AJ270778
AK299295
AL135792
AL158212
AL445486
AL451084
BAA86225
BAG61310
BAH24004
BC032656
C6ZRJ6
C6ZRJ7
C6ZRK5
CAA72166
CAB013535
CAB97212
CAB97213
CAB97214
CAB97215
CAB97216
CAB97217
CAB97218
CAB97219
CAG38811
CCDS53577
CCDS53578
CCDS55729
CCDS7576
CH471066
CR536574
E2GH26
EAW49510
EAW49513
EAW49515
EAW49516
ENSG00000148737
ENSP00000344823
ENSP00000347949
ENSP00000348274
ENSP00000358404
ENSP00000446172
ENSP00000486891
ENST00000352065
ENST00000355717
ENST00000355995
ENST00000369397
ENST00000538897
ENST00000627217
EntrezGene:6934
FJ010167
FJ010169
FJ010172
GE83165
GO:0000122
GO:0000228
GO:0000790
GO:0000978
GO:0000981
GO:0001103
GO:0001568
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0006259
GO:0006351
GO:0006355
GO:0006357
GO:0006790
GO:0006810
GO:0006913
GO:0007049
GO:0007050
GO:0007165
GO:0007223
GO:0007267
GO:0008013
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009749
GO:0010909
GO:0016055
GO:0016605
GO:0019899
GO:0019901
GO:0022607
GO:0030154
GO:0031016
GO:0032024
GO:0032092
GO:0032350
GO:0032991
GO:0032993
GO:0034641
GO:0035257
GO:0042592
GO:0042593
GO:0043226
GO:0043433
GO:0043565
GO:0043570
GO:0044212
GO:0044281
GO:0044334
GO:0045295
GO:0045444
GO:0045892
GO:0045944
GO:0046827
GO:0048625
GO:0048660
GO:0048856
GO:0051276
GO:0051897
GO:0060070
GO:0065003
GO:0070016
GO:0070369
GO:0090090
GO:1904837
GO:2000675
GO:2001237
H0YEE5
HGNC:11641
HM352839
HM352842
HM352844
HM352845
HM352846
HM352847
HM352849
HM352850
HPA038800
Hs.173638.0.S1_3p_s_at
Hs.173638.0.S2_3p_s_at
Hs.173638.0.S3_3p_a_at
Hs.173638.0.S3_3p_at
Hs.173638.1.S1_3p_x_at
Hs.173638.2.S1_3p_a_at
Hs.173638.2.S1_3p_x_at
Hs.283857.0.S1_3p_s_at
ILMN_1672486
IPR009071
IPR013558
IPR024940
IPR027397
IPR028773
IPR036910
MIM:125853
MIM:602228
NM_001146274
NM_001146283
NM_001146284
NM_001146286
NM_001198528
NM_001198529
NM_001198531
NM_030756
NP_001139746
NP_001139755
NP_001139756
NP_001139758
NP_001185457
NP_001185458
NP_001185460
NP_110383
PF00505
PF08347
Q5JRY3
Q5JRY4
Q5JRY5
Q5VVR5
Q5VVR7
Q5VVR8
Q6FHW4
SM00398
SM01366
TC10000820.hg
TC10002300.hg
TCF7L2
TCF7L2-204
TCF7L2-205
TCF7L2-206
TCF7L2-210
TCF7L2-218
TCF7L2-222
uc001lac.5
uc001lae.5
uc001lag.5
uc010qrp.3
uc021pyi.2
uc021pyj.2
UPI000002B4A5
UPI000002B4A6
UPI000002B4A7
UPI0000136848
UPI0001892BCB
UPI0001E6E5B3
XM_005270071
XM_005270075
XM_005270077
XM_005270079
XM_005270080
XM_005270084
XM_005270086
XM_005270088
XM_005270093
XM_005270094
XM_005270095
XM_005270096
XM_005270100
XM_005270101
XM_005270102
XM_005270103
XM_005270104
XM_017016586
XM_017016587
XM_017016592
XM_017016593
XM_017016595
XM_017016596
XP_005270128
XP_005270132
XP_005270134
XP_005270136
XP_005270137
XP_005270141
XP_005270143
XP_005270145
XP_005270150
XP_005270151
XP_005270152
XP_005270153
XP_005270157
XP_005270158
XP_005270159
XP_005270160
XP_005270161
XP_016872075
XP_016872076
XP_016872081
XP_016872082
XP_016872084
XP_016872085
Y11306
Y11306_rna1_at
Participant Of
hasMember
Other forms of this molecule
TCF7L2 R397W [nucleoplasm]
pT201,T212-TCF7L2 [nucleoplasm]
TCF7L2 [nucleoplasm]
Modified Residues
Name
Replacement of residues 485 to 506 by SAFATYKVKAAASAHPLQMEAY
Disease
Name Identifier Synonyms
stomach cancer 10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
colorectal cancer 9256
Cross References
RefSeq
GeneCards
PRO
Orphanet
PDB
Interactors (6)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P35222 CTNNB1  24 0.967 25
 UniProt:Q13761 RUNX3  7 0.656 14
 UniProt:Q08050 FOXM1  3 0.612 7
 UniProt:Q14526 HIC1  2 0.61 6
 UniProt:Q9UER7 DAXX  2 0.543 5
 UniProt:P09874 PARP1  4 0.462 5