Reactome | CUL3 [cytosol]

CUL3 [cytosol]

Stable Identifier

R-HSA-975979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cullin-3, CUL3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13618 CUL3

Gene Names

CUL3, KIAA0617

Chain

initiator methionine:1, chain:2-768

Reference Genes

BioGPS Gene:8452 CUL3

COSMIC (genes):CUL3 CUL3

CTD Gene:8452 CUL3

dbSNP Gene:8452 CUL3

ENSEMBL:ENSG00000036257.14 CUL3

HGNC:2553 CUL3

KEGG Gene (Homo sapiens):8452 CUL3

Monarch:8452 CUL3

NCBI Gene:8452 CUL3

OMIM:603136 CUL3

UCSC:Q13618 CUL3

Reference Transcript

Other Identifiers

11716505_a_at

11716506_s_at

11716507_at

11716508_at

16909049

201370_PM_s_at

201370_s_at

201371_PM_s_at

201371_s_at

201372_PM_s_at

201372_s_at

2601552

2601553

2601554

2601555

2601556

2601557

2601560

2601562

2601570

2601571

2601573

2601577

2601579

2601581

2601582

2601584

2601585

2601587

2601589

2601601

2601607

2601610

2601615

2601616

37702_at

8059393

8452

A_23_P209288

A_24_P140030

A_33_P3321150

GE53336

GO:0000082

GO:0000122

GO:0000209

GO:0000278

GO:0000902

GO:0000910

GO:0000922

GO:0001701

GO:0001831

GO:0003824

GO:0004842

GO:0005112

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005827

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0006351

GO:0006355

GO:0006357

GO:0006511

GO:0006513

GO:0006888

GO:0006954

GO:0007010

GO:0007049

GO:0007059

GO:0007080

GO:0007229

GO:0007369

GO:0008284

GO:0010467

GO:0012501

GO:0016020

GO:0016055

GO:0016192

GO:0016477

GO:0016567

GO:0016740

GO:0017145

GO:0023052

GO:0030030

GO:0030154

GO:0030163

GO:0030332

GO:0031145

GO:0031208

GO:0031398

GO:0031461

GO:0031463

GO:0031514

GO:0031625

GO:0031648

GO:0032467

GO:0035024

GO:0036126

GO:0036211

GO:0040016

GO:0042802

GO:0042995

GO:0043149

GO:0043161

GO:0043226

GO:0044346

GO:0045842

GO:0048208

GO:0048856

GO:0048870

GO:0051301

GO:0051865

GO:0061024

GO:0061630

GO:0065003

GO:0070062

GO:0070936

GO:0071630

GO:0072576

GO:0072686

GO:0097193

GO:0098794

GO:0098978

GO:0140014

GO:0140096

GO:0140252

GO:1901992

HMNXSV003004059

Hs.78946.0.A2_3p_a_at

ILMN_1653670

PH_hs_0004555

TC02002826.hg

U58089_at

g3139078_3p_a_at

g4503164_3p_a_at

Participates

as a member of

as a component of

Other forms of this molecule

CUL3 [nucleoplasm]

G76-NEDD8-K712-CUL3 [cytosol]

Inferred To

cul3 [cytosol] (Danio rerio)

cul3 [cytosol] (Schizosaccharomyces pombe)

cul3 [cytosol] (Xenopus tropicalis)

CUL3 [cytosol] (Bos taurus)

CUL3 [cytosol] (Canis familiaris)

CUL3 [cytosol] (Gallus gallus)

CUL3 [cytosol] (Saccharomyces cerevisiae)

CUL3 [cytosol] (Sus scrofa)

Cul3 [cytosol] (Drosophila melanogaster)

Cul3 [cytosol] (Mus musculus)

Cul3 [cytosol] (Rattus norvegicus)

cul-3 [cytosol] (Caenorhabditis elegans)

culC [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001244127.1, NP_001244126.1, NP_003581.1

OpenTargets

ENSG00000036257

HPA

ENSG00000036257-CUL3

GeneCards

Q13618

Ensembl

ENST00000409777, ENSP00000264414, ENST00000409096, ENSP00000387200, ENSG00000036257, ENSP00000386525, ENST00000264414, ENSP00000343601, ENST00000344951

PRO

Q13618

Pharos - Targets

Q13618

Orphanet

21177

HMDB Protein

HMDBP12790

PDB

4HXI, 4APF, 4EOZ, 5NLB, 2MYM, 2MYL, 4AP2, 6I2M

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.83	11
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.641	3
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.623	6
UniProt:Q86VP6 CAND1	5	CAND1 [nucleoplasm] (R-HSA-8955089) CAND1 [cytosol] (R-HSA-5691146) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399)	0.623	6
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.602	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.547	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	7
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	2
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.527	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.527	2
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.527	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	2
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2
UniProt:P55265 ADAR	1	ADAR [nucleoplasm] (R-HSA-53939)	0.527	2
UniProt:Q8IWE4 DCUN1D3	2	MyrG-DCUN1D3 [plasma membrane] (R-HSA-8956204) DCUN1D3 [cytosol] (R-HSA-8951782)	0.499	2