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CUL3 [cytosol]
Stable Identifier
R-HSA-975979
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cullin-3, CUL3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)
KBTBD7:CUL3:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
RHOBTB3 ATPase cycle (Homo sapiens)
RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB1 GTPase cycle (Homo sapiens)
RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of DVL (Homo sapiens)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13618 CUL3
Gene Names
CUL3, KIAA0617
Chain
initiator methionine:1, chain:2-768
Reference Genes
BioGPS Gene:8452 CUL3
COSMIC (genes):CUL3 CUL3
CTD Gene:8452 CUL3
dbSNP Gene:8452 CUL3
ENSEMBL:ENSG00000036257.14 CUL3
HGNC:2553 CUL3
KEGG Gene (Homo sapiens):8452 CUL3
Monarch:8452 CUL3
NCBI Gene:8452 CUL3
OMIM:603136 CUL3
UCSC:Q13618 CUL3
Reference Transcript
RefSeq:NM_001257197.1 CUL3
RefSeq:NM_003590.4 CUL3
RefSeq:NM_001257198.1 CUL3
Other Identifiers
11716505_a_at
11716506_s_at
11716507_at
11716508_at
16909049
201370_PM_s_at
201370_s_at
201371_PM_s_at
201371_s_at
201372_PM_s_at
201372_s_at
2601552
2601553
2601554
2601555
2601556
2601557
2601560
2601562
2601570
2601571
2601573
2601577
2601579
2601581
2601582
2601584
2601585
2601587
2601589
2601601
2601607
2601610
2601615
2601616
37702_at
8059393
8452
A_23_P209288
A_24_P140030
A_33_P3321150
GE53336
GO:0000082
GO:0000122
GO:0000209
GO:0000278
GO:0000902
GO:0000910
GO:0000922
GO:0001701
GO:0001831
GO:0003824
GO:0004842
GO:0005112
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005827
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0006351
GO:0006355
GO:0006357
GO:0006511
GO:0006513
GO:0006888
GO:0006954
GO:0007010
GO:0007049
GO:0007059
GO:0007080
GO:0007229
GO:0007369
GO:0008284
GO:0010467
GO:0012501
GO:0016020
GO:0016055
GO:0016192
GO:0016477
GO:0016567
GO:0016740
GO:0017145
GO:0023052
GO:0030030
GO:0030154
GO:0030163
GO:0030332
GO:0031145
GO:0031208
GO:0031398
GO:0031461
GO:0031463
GO:0031514
GO:0031625
GO:0031648
GO:0032467
GO:0035024
GO:0036126
GO:0036211
GO:0040016
GO:0042802
GO:0042995
GO:0043149
GO:0043161
GO:0043226
GO:0044346
GO:0045842
GO:0048208
GO:0048856
GO:0048870
GO:0051301
GO:0051865
GO:0061024
GO:0061630
GO:0065003
GO:0070062
GO:0070936
GO:0071630
GO:0072576
GO:0072686
GO:0097193
GO:0098794
GO:0098978
GO:0140014
GO:0140096
GO:0140252
GO:1901992
HMNXSV003004059
Hs.78946.0.A2_3p_a_at
ILMN_1653670
PH_hs_0004555
TC02002826.hg
U58089_at
g3139078_3p_a_at
g4503164_3p_a_at
Participates
as a member of
RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
as a component of
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KBTBD7:CUL3:RBX1 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
Other forms of this molecule
CUL3 [nucleoplasm]
G76-NEDD8-K712-CUL3 [cytosol]
Inferred To
cul3 [cytosol]
(Danio rerio)
cul3 [cytosol]
(Schizosaccharomyces pombe)
cul3 [cytosol]
(Xenopus tropicalis)
CUL3 [cytosol]
(Bos taurus)
CUL3 [cytosol]
(Canis familiaris)
CUL3 [cytosol]
(Gallus gallus)
CUL3 [cytosol]
(Saccharomyces cerevisiae)
CUL3 [cytosol]
(Sus scrofa)
Cul3 [cytosol]
(Drosophila melanogaster)
Cul3 [cytosol]
(Mus musculus)
Cul3 [cytosol]
(Rattus norvegicus)
cul-3 [cytosol]
(Caenorhabditis elegans)
culC [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001244127.1
,
NP_001244126.1
,
NP_003581.1
OpenTargets
ENSG00000036257
HPA
ENSG00000036257-CUL3
GeneCards
Q13618
Ensembl
ENST00000409777
,
ENSP00000264414
,
ENST00000409096
,
ENSP00000387200
,
ENSG00000036257
,
ENSP00000386525
,
ENST00000264414
,
ENSP00000343601
,
ENST00000344951
PRO
Q13618
Pharos - Targets
Q13618
Orphanet
21177
HMDB Protein
HMDBP12790
PDB
4HXI
,
4APF
,
4EOZ
,
5NLB
,
2MYM
,
2MYL
,
4AP2
,
6I2M
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.83
11
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.641
3
UniProt:O94888 UBXN7
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.623
6
UniProt:Q86VP6 CAND1
5
CAND1 [nucleoplasm]
(R-HSA-8955089)
CAND1 [cytosol]
(R-HSA-5691146)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
0.623
6
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.602
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.547
3
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
7
UniProt:O43143 DHX15
1
DHX15 [nucleoplasm]
(R-HSA-5688097)
0.527
2
UniProt:Q8IY81 FTSJ3
1
FTSJ3 [nucleoplasm]
(R-HSA-6791507)
0.527
2
UniProt:Q13427 PPIG
2
PPIG [nucleoplasm]
(R-HSA-9769592)
PPIG [cytosol]
(R-HSA-9728768)
0.527
2
UniProt:Q15084 PDIA6
3
PDIA6 [endoplasmic reticulum membrane]
(R-HSA-535530)
p-PDIA6 [endoplasmic reticulum lumen]
(R-HSA-8957031)
PDIA6 [endoplasmic reticulum lumen]
(R-HSA-3009049)
0.527
2
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
0.527
2
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.527
2
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.527
2
UniProt:P55265 ADAR
1
ADAR [nucleoplasm]
(R-HSA-53939)
0.527
2
UniProt:Q8IWE4 DCUN1D3
2
MyrG-DCUN1D3 [plasma membrane]
(R-HSA-8956204)
DCUN1D3 [cytosol]
(R-HSA-8951782)
0.499
2
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