Reactome | TBX5 [nucleoplasm]

TBX5 [nucleoplasm]

Stable Identifier

R-HSA-2032786

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

T-box transcription factor TBX5

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99593 TBX5

Gene Names

TBX5

Chain

chain:1-518

Reference Genes

BioGPS Gene:6910 TBX5

COSMIC (genes):TBX5 TBX5

CTD Gene:6910 TBX5

dbSNP Gene:6910 TBX5

ENSEMBL:ENSG00000089225.20 TBX5

HGNC:11604 TBX5

KEGG Gene (Homo sapiens):6910 TBX5

Monarch:6910 TBX5

NCBI Gene:6910 TBX5

OMIM:601620 TBX5

UCSC:Q99593 TBX5

Reference Transcript

Other Identifiers

0004150128

0006040075

0006760441

11715291_s_at

11732527_a_at

11732528_s_at

11732529_a_at

11736973_a_at

11750894_a_at

145_s_at

16770664

207155_PM_at

207155_at

211886_PM_s_at

211886_s_at

240715_PM_at

240715_at

33558_at

3472629

3472630

3472631

3472632

3472633

3472635

3472636

3472644

3472651

3472657

3472658

3472664

3472665

3472666

3472667

3472668

3472672

3472673

3472674

3472675

3472676

3472680

3472682

3472683

3472686

3472688

380_at

49443_at

6910

77296_at

7966668

A_23_P25176

A_24_P30557

GE60267

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0001708

GO:0002009

GO:0003013

GO:0003163

GO:0003166

GO:0003167

GO:0003181

GO:0003197

GO:0003218

GO:0003229

GO:0003281

GO:0003283

GO:0003677

GO:0003700

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007267

GO:0007389

GO:0007507

GO:0008285

GO:0010719

GO:0023052

GO:0030154

GO:0030324

GO:0030326

GO:0030336

GO:0032991

GO:0032993

GO:0034330

GO:0035115

GO:0035136

GO:0043226

GO:0043565

GO:0045893

GO:0045944

GO:0048856

GO:0048870

GO:0051891

GO:0055007

GO:0060038

GO:0060039

GO:0060044

GO:0060045

GO:0060371

GO:0060413

GO:0060928

GO:0060929

GO:0060980

GO:0061629

GO:0072513

GO:0086019

GO:0086054

GO:1901846

GO:1903598

GO:1903781

HMNXSV003011921

HMNXSV003036482

Hs.128093.0.A1_3p_at

ILMN_1742362

ILMN_1781591

ILMN_1822239

ILMN_2282379

ILMN_2376958

PH_hs_0033046

PH_hs_0034959

TC12001996.hg

U80987_s_at

Y09445_at

g2281318_3p_a_at

g4504454_3p_at

Participates

as a component of

TBX5:WWTR1:PCAF [nucleoplasm] (Homo sapiens)

as an input of

WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)

Inferred To

tbx-36 [nucleoplasm] (Caenorhabditis elegans)

tbx-31 [nucleoplasm] (Caenorhabditis elegans)

Homologues of TBX5 [nucleoplasm] (Caenorhabditis elegans)

tbx-9 [nucleoplasm] (Caenorhabditis elegans)

tbx-38 [nucleoplasm] (Caenorhabditis elegans)

tbx-7 [nucleoplasm] (Caenorhabditis elegans)

tbx-8 [nucleoplasm] (Caenorhabditis elegans)

TBX5 [nucleoplasm] (Bos taurus)

TBX5 [nucleoplasm] (Canis familiaris)

TBX5 [nucleoplasm] (Gallus gallus)

TBX5 [nucleoplasm] (Sus scrofa)

tbx-37 [nucleoplasm] (Caenorhabditis elegans)

tbx-33 [nucleoplasm] (Caenorhabditis elegans)

tbx5a [nucleoplasm] (Danio rerio)

org-1 [nucleoplasm] (Drosophila melanogaster)

tbx-34 [nucleoplasm] (Caenorhabditis elegans)

Tbx5 [nucleoplasm] (Mus musculus)

tbx-32 [nucleoplasm] (Caenorhabditis elegans)

tbx5 [nucleoplasm] (Xenopus tropicalis)

tbx-11 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000183.2, NP_542448.1, NP_852259.1

OpenTargets

ENSG00000089225

GeneCards

Q99593

HPA

ENSG00000089225-TBX5

Ensembl

ENSP00000384152, ENST00000349716, ENSP00000433292, ENSG00000089225, ENSP00000337723, ENSP00000309913, ENST00000310346, ENST00000405440, ENST00000526441

PRO

Q99593

Pharos - Targets

Q99593

Orphanet

15589

PDB

5BQD, 2X6V, 2X6U, 4S0H

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	7	p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.558	4
UniProt:Q9UQB8-6 BAIAP2			0.556	3
UniProt:O75800 ZMY10			0.556	3
IntAct:EBI-1212037 TBE			0.525	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.462	3

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