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TNIK [cytosol]
Stable Identifier
R-HSA-3214889
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TRAF2 and NCK-interacting protein kinase, KIAA0551
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)
MINK1/TNIK [cytosol] (Homo sapiens)
TNIK [cytosol] (Homo sapiens)
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
MINK1/TNIK [cytosol] (Homo sapiens)
TNIK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKE5 TNIK
Gene Names
TNIK, KIAA0551
Chain
chain:1-1360
Reference Genes
BioGPS Gene:23043 TNIK
COSMIC (genes):TNIK TNIK
CTD Gene:23043 TNIK
dbSNP Gene:23043 TNIK
ENSEMBL:ENSG00000154310.17 TNIK
HGNC:30765 TNIK
KEGG Gene (Homo sapiens):23043 TNIK
Monarch:23043 TNIK
NCBI Gene:23043 TNIK
OMIM:610005 TNIK
UCSC:Q9UKE5 TNIK
Reference Transcript
RefSeq:NM_001161565.2 TNIK
RefSeq:NM_015028.3 TNIK
RefSeq:NM_001161564.2 TNIK
RefSeq:NM_001161560.2 TNIK
RefSeq:NM_001161563.2 TNIK
RefSeq:NM_001161561.2 TNIK
RefSeq:NM_001161566.2 TNIK
RefSeq:NM_001161562.2 TNIK
Other Identifiers
11739878_at
11739879_a_at
11745635_a_at
16961501
211828_PM_s_at
211828_s_at
213107_PM_at
213107_at
213109_PM_at
213109_at
23043
242783_PM_at
242783_at
2705249
2705250
2705251
2705252
2705254
2705256
2705258
2705260
2705261
2705263
2705265
2705267
2705268
2705269
2705270
2705271
2705272
2705273
2705276
2705279
2705280
2705281
2705284
2705288
2705290
2705291
2705294
2705298
2705301
2705302
2705306
2705308
2705309
2705311
2705312
2705313
2705318
2705319
2705320
2705325
2705327
2705330
2705333
2705335
2705338
2705339
2705340
2705344
2705352
2705383
2705393
2705394
2705395
32680_at
46809_at
8092095
85480_at
A_23_P135568
A_24_P350576
A_32_P119704
A_33_P3213596
GE53272
GO:0000165
GO:0000166
GO:0001934
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0007010
GO:0007399
GO:0010243
GO:0016055
GO:0016301
GO:0016310
GO:0016324
GO:0016740
GO:0023052
GO:0030033
GO:0030154
GO:0031410
GO:0031532
GO:0035556
GO:0036211
GO:0043226
GO:0043408
GO:0046330
GO:0046777
GO:0048812
GO:0048814
GO:0048856
GO:0055037
GO:0070062
GO:0072659
GO:0098793
GO:0098978
GO:0099092
GO:0106310
GO:0140096
HMNXSV003033653
Hs.170204.0.S2_3p_at
Hs.170204.0.S3_3p_at
Hs.46473.0.A1_3p_at
ILMN_1687442
PH_hs_0003359
PH_hs_0038528
TC03001998.hg
TC03003206.hg
g6110356_3p_a_at
Participates
as a candidate of
MINK1/TNIK [cytosol] (Homo sapiens)
Inferred To
TNIK [cytosol]
(Danio rerio)
TNIK [cytosol]
(Drosophila melanogaster)
TNIK [cytosol]
(Mus musculus)
TNIK [cytosol]
(Rattus norvegicus)
TNIK [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_055843.1
,
NP_001155032.1
,
NP_001155035.1
,
NP_001155033.1
,
NP_001155038.1
,
NP_001155036.1
,
NP_001155034.1
,
NP_001155037.1
ZINC - World Drugs
TNIK_HUMAN
Guide to Pharmacology - Targets
2244
OpenTargets
ENSG00000154310
ZINC - FDA approved
TNIK_HUMAN
ZINC - Substances
TNIK_HUMAN
ZINC target
Q9UKE5
ZINC - Biogenic
TNIK_HUMAN
PRO
Q9UKE5
PDB
6RA7
,
7XZQ
,
5CWZ
,
5AX9
,
7XZR
,
2X7F
,
6RA5
,
5D7A
ZINC - Investigational
TNIK_HUMAN
IntEnz
2.7.11.1
GeneCards
Q9UKE5
HPA
ENSG00000154310-TNIK
Ensembl
ENST00000475336
,
ENST00000341852
,
ENSP00000419990
,
ENSG00000154310
,
ENST00000470834
,
ENSP00000345352
,
ENSP00000418156
,
ENSP00000349880
,
ENSP00000399511
,
ENST00000284483
,
ENST00000357327
,
ENST00000460047
,
ENSP00000418916
,
ENSP00000418378
,
ENST00000488470
,
ENSP00000284483
,
ENST00000436636
Pharos - Targets
Q9UKE5
Orphanet
23899
ZINC - Predictions - Purchasable
TNIK_HUMAN
HMDB Protein
HMDBP09464
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
0.591
3
UniProt:P12081 HARS1
1
HARS [cytosol]
(R-HSA-379554)
0.553
2
UniProt:Q8IX03 WWC1
1
WWC1 [cytosol]
(R-HSA-2038400)
0.553
2
UniProt:Q9Y618 NCOR2
2
monoSUMO1-K672-NCOR2 [nucleoplasm]
(R-HSA-3927904)
NCOR2 [nucleoplasm]
(R-HSA-442469)
0.553
2
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.544
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.525
3
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.499
2
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.499
3
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