Reactome | TNIK [cytosol]

TNIK [cytosol]

Stable Identifier

R-HSA-3214889

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRAF2 and NCK-interacting protein kinase, KIAA0551

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UKE5 TNIK

Gene Names

TNIK, KIAA0551

Chain

chain:1-1360

Reference Genes

BioGPS Gene:23043 TNIK

COSMIC (genes):TNIK TNIK

CTD Gene:23043 TNIK

dbSNP Gene:23043 TNIK

ENSEMBL:ENSG00000154310 TNIK

HGNC:30765 TNIK

KEGG:hsa:23043 TNIK

Monarch:23043 TNIK

NCBI Gene:23043 TNIK

OMIM:610005 TNIK

UCSC:Q9UKE5 TNIK

Reference Transcript

Other Identifiers

11739878_at

11739879_a_at

11745635_a_at

16961501

211828_PM_s_at

211828_s_at

213107_PM_at

213107_at

213109_PM_at

213109_at

23043

239288_PM_at

239288_at

242783_PM_at

242783_at

2705249

2705250

2705251

2705252

2705254

2705256

2705258

2705260

2705261

2705263

2705265

2705267

2705268

2705269

2705270

2705271

2705272

2705273

2705274

2705276

2705277

2705278

2705279

2705280

2705281

2705284

2705285

2705288

2705289

2705290

2705291

2705294

2705298

2705301

2705302

2705303

2705306

2705308

2705309

2705311

2705312

2705313

2705318

2705319

2705320

2705325

2705327

2705330

2705333

2705335

2705338

2705339

2705340

2705344

2705352

2705375

2705383

2705393

2705394

2705395

32680_at

46809_at

8092095

81005_at

85480_at

A_21_P0000547

A_23_P135568

A_24_P350576

A_32_P119704

A_33_P3213596

GE53272

GO:0000165

GO:0001934

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005856

GO:0006468

GO:0007010

GO:0007399

GO:0016055

GO:0016324

GO:0016740

GO:0030033

GO:0030036

GO:0031410

GO:0035556

GO:0043226

GO:0043408

GO:0046330

GO:0046777

GO:0048812

GO:0048814

GO:0048856

GO:0055037

GO:0070062

GO:0072659

GO:0098793

GO:0098978

GO:0099092

GO:0106310

GO:0140096

HMNXSV003033653

Hs.153451.0.A1_3p_at

Hs.170204.0.S2_3p_at

Hs.170204.0.S3_3p_at

Hs.46473.0.A1_3p_at

ILMN_1687442

PH_hs_0003359

PH_hs_0038528

TC03001998.hg

TC03003206.hg

g6110356_3p_a_at

Participates

as a candidate of

MINK1/TNIK [cytosol] (Homo sapiens)

Inferred To

TNIK [cytosol] (Caenorhabditis elegans)

TNIK [cytosol] (Drosophila melanogaster)

TNIK [cytosol] (Mus musculus)

TNIK [cytosol] (Rattus norvegicus)

TNIK [cytosol] (Sus scrofa)

Homologues of TNIK [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001155032.1, NP_001155033.1, NP_001155034.1, NP_001155036.1, NP_001155038.1, NP_055843.1, NP_001155037.1, NP_001155035.1

Guide to Pharmacology - Targets

2244

OpenTargets

ENSG00000154310

ENSEMBL

ENSP00000399511, ENST00000436636, ENST00000357327, ENST00000460047, ENSG00000154310, ENSP00000349880, ENSP00000345352, ENSP00000419990, ENST00000488470, ENST00000475336, ENST00000341852, ENSP00000418156, ENST00000470834, ENSP00000284483, ENSP00000418378, ENSP00000418916, ENST00000284483

ZINC - FDA approved

TNIK_HUMAN

ZINC - Substances

TNIK_HUMAN

ZINC - Biogenic

TNIK_HUMAN

ZINC target

Q9UKE5

PRO

Q9UKE5

GlyGen

Q9UKE5

PDB

6RA5, 5CWZ, 7XZQ, 6RA7, 8WM0, 8X88, 5D7A, 7XZR, 2X7F, 5AX9

ZINC - Investigational

TNIK_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000154310-TNIK

GeneCards

TNIK

Pharos - Targets

Q9UKE5

Orphanet

TNIK

ZINC - Predictions - Purchasable

TNIK_HUMAN

HMDB Protein

HMDBP09464

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.591	3
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.564	2
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.553	2
UniProt:P12081 HARS1	1	HARS [cytosol] (R-HSA-379554)	0.553	2
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.553	2
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.544	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.525	3
UniProt:O43318 MAP3K7	10	p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [endosome membrane] (R-HSA-450315) p-T187-MAP3K7 [cytosol] (R-HSA-206014) p-MAP3K7 [cytosol] (R-HSA-168163) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968)	0.499	3
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.499	2

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