Reactome | pS45-CTNNB1 T41A [cytosol]

pS45-CTNNB1 T41A [cytosol]

Stable Identifier

R-HSA-4836868

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Catenin beta-1, CTNB1_HUMAN

Icon

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by CTNNB1 phospho-site mutants (Homo sapiens)
      - CTNNB1 T41 mutants aren't phosphorylated (Homo sapiens)
        
        CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
        
        pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        pS45-CTNNB1 T41 mutants [cytosol] (Homo sapiens)
        
        pS45-CTNNB1 T41A [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
9065402	Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Barker, N, Clevers, HC, Morin, PJ, Kinzler, KW, Vogelstein, B, Korinek, V, Sparks, AB	Science	1997
10700176	AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 Miwa, N, Tokino, T, Furukawa, Y, Fujita, M, Daigo, Y, Nishiwaki, T, Nakamura, Y, Kato, T, Satoh, S, Kawasoe, T, Yamaoka, Y, Murata, M, Sasaki, Y, Ishiguro, H, Shimano, T, Imaoka, S	Nat. Genet.	2000

External Reference Information

External Reference

UniProt:P35222 CTNNB1

Gene Names

CTNNB1, CTNNB, OK/SW-cl.35, PRO2286

Chain

initiator methionine:, chain:2-781

Reference Genes

BioGPS Gene:1499 CTNNB1

COSMIC (genes):CTNNB1 CTNNB1

CTD Gene:1499 CTNNB1

dbSNP Gene:1499 CTNNB1

ENSEMBL:ENSG00000168036 CTNNB1

ENSEMBL_homo_sapiens_GENE:ENSG00000168036.18 CTNNB1

HGNC:2514 CTNNB1

KEGG Gene (Homo sapiens):1499 CTNNB1

Monarch:1499 CTNNB1

NCBI Gene:1499 CTNNB1

OMIM:116806 CTNNB1

UCSC:P35222 CTNNB1

Reference Transcript

Other Identifiers

11722167_s_at

11747387_a_at

11747388_x_at

11748951_a_at

11748952_x_at

11749021_s_at

11749022_x_at

11750680_x_at

1499

1554411_PM_at

1554411_at

16939558

201533_PM_at

201533_at

2618941

2618942

2618945

2618946

2618952

2618953

2618955

2618957

2618958

2618959

2618960

2618961

2618962

2618965

2618967

2618969

2618971

2618973

2618975

2618978

2618980

2618981

2618982

2618983

40777_at

8079021

A_14_P106050

A_14_P131897

A_23_P29495

A_23_P29499

A_33_P3421695

GE60116

GE752547

GO:0000122

GO:0000165

GO:0000209

GO:0000278

GO:0000578

GO:0000791

GO:0000902

GO:0000922

GO:0001221

GO:0001222

GO:0001501

GO:0001569

GO:0001570

GO:0001649

GO:0001658

GO:0001701

GO:0001702

GO:0001706

GO:0001708

GO:0001711

GO:0001764

GO:0001822

GO:0001837

GO:0001840

GO:0001894

GO:0001944

GO:0002052

GO:0002053

GO:0002062

GO:0002067

GO:0002089

GO:0002376

GO:0003151

GO:0003266

GO:0003338

GO:0003340

GO:0003682

GO:0003713

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0005916

GO:0005923

GO:0005925

GO:0005938

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006790

GO:0007010

GO:0007155

GO:0007160

GO:0007268

GO:0007398

GO:0007399

GO:0007403

GO:0007405

GO:0007507

GO:0008104

GO:0008283

GO:0008284

GO:0008285

GO:0008543

GO:0009410

GO:0009948

GO:0009950

GO:0009953

GO:0009954

GO:0010463

GO:0010467

GO:0010468

GO:0010628

GO:0010629

GO:0010718

GO:0010909

GO:0012501

GO:0014704

GO:0016020

GO:0016055

GO:0016192

GO:0016323

GO:0016327

GO:0016328

GO:0016331

GO:0016342

GO:0016525

GO:0016600

GO:0016922

GO:0019827

GO:0019899

GO:0019900

GO:0019901

GO:0019903

GO:0021819

GO:0021854

GO:0022009

GO:0022405

GO:0022414

GO:0023052

GO:0030018

GO:0030027

GO:0030054

GO:0030097

GO:0030154

GO:0030163

GO:0030182

GO:0030217

GO:0030316

GO:0030324

GO:0030331

GO:0030539

GO:0030856

GO:0030858

GO:0030877

GO:0030900

GO:0030901

GO:0030902

GO:0030997

GO:0031016

GO:0031069

GO:0031253

GO:0031396

GO:0031528

GO:0031625

GO:0031641

GO:0032200

GO:0032212

GO:0032331

GO:0032355

GO:0032968

GO:0032991

GO:0032993

GO:0033077

GO:0033234

GO:0034330

GO:0034332

GO:0034333

GO:0034394

GO:0034750

GO:0035050

GO:0035112

GO:0035115

GO:0035116

GO:0035315

GO:0035995

GO:0036023

GO:0036211

GO:0036520

GO:0042127

GO:0042129

GO:0042475

GO:0042733

GO:0042734

GO:0042981

GO:0042995

GO:0043065

GO:0043066

GO:0043161

GO:0043226

GO:0043231

GO:0043296

GO:0043410

GO:0043524

GO:0043525

GO:0043588

GO:0044325

GO:0044338

GO:0045177

GO:0045202

GO:0045211

GO:0045294

GO:0045296

GO:0045453

GO:0045595

GO:0045596

GO:0045597

GO:0045603

GO:0045667

GO:0045669

GO:0045670

GO:0045671

GO:0045743

GO:0045765

GO:0045892

GO:0045893

GO:0045944

GO:0045976

GO:0046332

GO:0048145

GO:0048469

GO:0048471

GO:0048489

GO:0048513

GO:0048538

GO:0048568

GO:0048599

GO:0048617

GO:0048643

GO:0048660

GO:0048664

GO:0048709

GO:0048715

GO:0048856

GO:0048870

GO:0050767

GO:0050768

GO:0050808

GO:0051145

GO:0051450

GO:0051884

GO:0051963

GO:0060066

GO:0060070

GO:0060173

GO:0060439

GO:0060440

GO:0060441

GO:0060479

GO:0060484

GO:0060487

GO:0060492

GO:0060742

GO:0060767

GO:0060769

GO:0060789

GO:0060856

GO:0060916

GO:0061047

GO:0061154

GO:0061198

GO:0061549

GO:0061550

GO:0061629

GO:0070062

GO:0070161

GO:0070369

GO:0070411

GO:0070602

GO:0071363

GO:0071681

GO:0071944

GO:0072033

GO:0072053

GO:0072054

GO:0072079

GO:0072089

GO:0072182

GO:0072497

GO:0090090

GO:0090279

GO:0090425

GO:0090575

GO:0097091

GO:0097190

GO:0097718

GO:0098609

GO:0098685

GO:0098831

GO:0098978

GO:0099092

GO:0140110

GO:0140297

GO:1901135

GO:1901331

GO:1903377

GO:1904888

GO:1904948

GO:1990138

GO:1990226

GO:1990403

GO:1990711

GO:1990791

GO:1990907

GO:1990909

GO:1990963

GO:2000008

GO:2000017

GO:2000179

GO:2000288

GO:2000648

GO:2001234

HMNXSV003034293

Hs2.171271.2.S1_3p_s_at

ILMN_1651617

ILMN_1726641

ILMN_1746396

ILMN_1757350

PH_hs_0024820

TC03000214.hg

X87838_at

g4503130_3p_at

Participates

as a candidate of

pS45-CTNNB1 T41 mutants [cytosol] (Homo sapiens)

Other forms of this molecule

CTNNB1 S45A [cytosol]

CTNNB1 S45F [cytosol]

CTNNB1 S45C [cytosol]

CTNNB1 S45Y [cytosol]

CTNNB1 S45N [cytosol]

CTNNB1 S45P [cytosol]

pT41,S45-CTNNB1 S37P [cytosol]

pT41,S45-CTNNB1 S37F [cytosol]

pT41,S45-CTNNB1 S37A [cytosol]

pT41,S45-CTNNB1 S37Y [cytosol]

pT41,S45-CTNNB1 S37C [cytosol]

pS37,T41,S45-CTNNB1 S33A [cytosol]

pS37,T41,S45-CTNNB1 S33T [cytosol]

pS37,T41,S45-CTNNB1 S33C [cytosol]

pS37,T41,S45-CTNNB1 S33F [cytosol]

pS37,T41,S45-CTNNB1 S33P [cytosol]

pS37,T41,S45-CTNNB1 S33Y [cytosol]

pS45-CTNNB1 T41N [cytosol]

pS45-CTNNB1 T41I [cytosol]

Ub-K,p-Y-CTNNB1 [cytosol]

p-Y-CTNNB1 [cytosol]

p-S552-CTNNB1 [nucleoplasm]

p-S552-CTNNB1 [cytosol]

CTNNB1 [plasma membrane]

p-S45 CTNNB1 [cytosol]

p-T41,S45 CTNNB1 [cytosol]

p-S37,T41,S45, CTNNB1 [cytosol]

p-S33,S37,T41,S45 CTNNB1 [cytosol]

CTNNB1(116-376) [cytosol]

CTNNB1(1-115) [cytosol]

CTNNB1 [cytosol]

CTNNB1 [nucleoplasm]

Modified Residues

Name

L-threonine 41 replaced with L-alanine

Coordinate

PsiMod

L-alanine residue [MOD:00010]

A protein modification that effectively converts a source amino acid residue to an L-alanine.

L-threonine removal [MOD:01647]

A protein modification that effectively removes or replaces an L-threonine.

Name

O-phospho-L-serine at 45

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
endometrial cancer	DOID:1380	primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
adrenal gland cancer	DOID:3953	malignant neoplasm of adrenal gland, adrenal cancer, malignant neoplasm of adrenal gland NOS (disorder), adrenal neoplasm, neoplasm of adrenal gland (disorder), malignant tumor of adrenal gland (disorder), tumor of the Adrenal gland, malignant Adrenal tumor
colorectal cancer	DOID:9256
hepatocellular carcinoma	DOID:684	adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
connective tissue cancer	DOID:201	connective tissue neoplasm, neoplasm of connective tissues (disorder), Tumour of connective tissue

Cross References

RefSeq

NP_001091680.1, NP_001895.1, XP_005264943.1, XP_016861227.1, NP_001091679.1

OpenTargets

ENSG00000168036

ZINC - Substances

CTNB1_HUMAN

ZINC target

P35222

PRO

P35222

PDB

2Z6H, 6M90, 2GL7, 6M91, 7UWO, 3SLA, 8EI9, 6M92, 1LUJ, 1T08, 6WNX, 6M93, 3TX7, 7AR4, 1JDH, 1JPW, 3SL9, 1P22, 8Y14, 2G57, 7UWI, 8Y0P, 1G3J, 3FQR, 6O9B, 7ZRB, 7AFW, 6O9C, 3DIW, 8Y0G, 1TH1, 4DJS, 8EIA, 6M94, 6WLX, 8EIC, 3FQN, 1QZ7, 8EIB

COSMIC

COSM13153, COSV62687862

GeneCards

P35222

HPA

ENSG00000168036-CTNNB1

Ensembl

ENST00000643541, ENST00000405570, ENST00000433400, ENST00000647390, ENSP00000494411, ENST00000645210, ENST00000396183, ENSP00000493533, ENST00000450969, ENST00000642992, ENSP00000412219, ENST00000643031, ENST00000645982, ENSP00000494677, ENSP00000495244, ENSP00000495360, ENSP00000385604, ENSP00000494845, ENSP00000495450, ENSP00000496021, ENST00000643977, ENSP00000496180, ENST00000646725, ENSP00000379488, ENST00000645320, ENSP00000494053, ENSP00000495719, ENSP00000494914, ENSP00000493610, ENST00000431914, ENSP00000409302, ENST00000643992, ENSP00000401599, ENSP00000495992, ENST00000396185, ENST00000349496, ENST00000642315, ENST00000642426, ENSP00000495076, ENST00000646369, ENSP00000344456, ENST00000643297, ENSP00000387455, ENSG00000168036, ENST00000644867, ENSP00000496385, ENST00000642248, ENSP00000379486, ENST00000441708

Pharos - Targets

P35222

Orphanet

15819

ZINC - Predictions - Purchasable

CTNB1_HUMAN

HMDB Protein

HMDBP02169

Interactors (121)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.97	27
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.962	23
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.962	22
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.955	18
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.951	20
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.94	44
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.94	22
UniProt:P19022 CDH2	3	p-CDH2 [endoplasmic reticulum lumen] (R-HSA-8956899) CDH2 [endoplasmic reticulum lumen] (R-HSA-8956761) CDH2 [plasma membrane] (R-HSA-191429)	0.932	12
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.926	8
UniProt:Q9UJU2 LEF1	2	LEF1 [nucleoplasm] (R-HSA-3214972) pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389)	0.893	10
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.893	8
UniProt:P35221 CTNNA1	2	CTNNA1 [cytosol] (R-HSA-191697) CTNNA1 [plasma membrane] (R-HSA-191735)	0.893	8
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.891	15
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.881	14
UniProt:P36402 TCF7	1	TCF7 [nucleoplasm] (R-HSA-3299543)	0.779	4
UniProt:O00512 BCL9	1	BCL9 [nucleoplasm] (R-HSA-201714)	0.725	5
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.723	4
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.714	10
UniProt:Q5JTC6 AMER1	5	AMER1 [cytosol] (R-HSA-1504189) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943)	0.711	9
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.709	6
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.692	3
UniProt:O35625 Axin1	8	Phospho Axin1 [cytosol] (R-MMU-206175) Axin1 [cytosol] (R-MMU-4641133) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-Axin1 [cytosol] (R-MMU-206040) Axin1 [cytosol] (R-MMU-195249)	0.688	4
UniProt:Q96AC1 FERMT2	1	FERMT2 [cytosol] (R-HSA-430275)	0.681	13
UniProt:O43707 ACTN4	3	ACTN4 [cytosol] (R-HSA-390558) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729)	0.68	7
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.672	16
UniProt:P26232 CTNNA2	1	CTNNA2 [cytosol] (R-HSA-448798)	0.669	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	14
UniProt:Q01826 SATB1	5	polySUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) monoSUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1 [nucleoplasm] (R-HSA-201593)	0.66	9
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.656	12
UniProt:P55197 AF10			0.656	5
UniProt:O00482-1 NR5A2	1	NR5A2-1 [nucleoplasm] (R-HSA-3008758)	0.65	5
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.646	3
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.641	4
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.628	8
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.623	3
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.615	3
UniProt:Q9UI47 CTNA3			0.615	4
UniProt:Q67FY2	1	Bcl9l [nucleoplasm] (R-MMU-3305843)	0.609	2
UniProt:Q9YGY0 AXIN1			0.609	2
UniProt:P23470 PTPRG			0.609	2
UniProt:P08575 PTPRC	2	PTPRC [secretory granule membrane] (R-HSA-6806150) PTPRC [plasma membrane] (R-HSA-197931)	0.609	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.609	2
UniProt:P49789 FHIT			0.602	4
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.602	5
UniProt:Q9UI47-1 CTNNA3			0.602	4
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.602	4
UniProt:P18012 SCTB			0.602	4
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.602	4
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.591	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.589	3
UniProt:Q13308 PTK7			0.581	5
UniProt:Q9BZE0 GLIS2			0.581	6
IntAct:EBI-4399559 UBIQ			0.576	3
UniProt:O75564 JERKY			0.576	3
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.576	5
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.573	2
UniProt:P33724	5	CAV1 [endocytic vesicle membrane] (R-CFA-535009) CAV1 [lipid droplet] (R-CFA-163510) CAV1 [early endosome membrane] (R-CFA-5368451) CAV1 [plasma membrane] (R-CFA-534994) CAV1 [Golgi membrane] (R-CFA-204504)	0.571	5
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.57	5
UniProt:Q8TEK3 DOT1L	1	DOT1L [nucleoplasm] (R-HSA-3239030)	0.564	3
UniProt:Q02952 AKAP12	1	AKAP12 [plasma membrane] (R-HSA-9715082)	0.564	2
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.564	2
UniProt:Q9DBG9	1	Tax1bp3 [cytosol] (R-MMU-5666217)	0.558	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:Q14114-3 Q141143			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.556	3
UniProt:Q92915-2 FGF14			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
UniProt:O14907 TAX1BP3	1	TAX1BP3 [cytosol] (R-HSA-5666217)	0.547	4
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.544	2
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.544	2
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.537	3
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.536	2
UniProt:P55286 CDH8	1	CDH8 [plasma membrane] (R-HSA-419000)	0.527	3
IntAct:EBI-5237192 AXIN2			0.527	2
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:Q9Y6N8 CDH10	1	CDH10 [plasma membrane] (R-HSA-418971)	0.527	2
UniProt:P22223 CDH3	1	CDH3 [plasma membrane] (R-HSA-198241)	0.527	2
UniProt:P09803 Cdh1	6	CDH1(155-700) [plasma membrane] (R-MMU-2534244) CDH1(701-882) [extracellular region] (R-MMU-2534158) Cdh1(157-884) [plasma membrane] (R-MMU-199081) CDH1(155-750) [plasma membrane] (R-MMU-202940) CDH1(751-882) [plasma membrane] (R-MMU-202929) CDH1(155-882) [plasma membrane] (R-MMU-198003)	0.527	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.525	3
UniProt:Q9EPK5 Wwtr1	4	phospho-Wwtr1 [cytosol] (R-MMU-2028665) Wwtr1 [nucleoplasm] (R-MMU-2064930) Wwtr1 [cytosol] (R-MMU-1629773) Wwtr1 [nucleoplasm] (R-MMU-1629775)	0.525	2
UniProt:P14618 PKM	3	PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.524	4
UniProt:A1Z199 A1Z199			0.524	2
UniProt:P14618-1 PKM	2	PolyUb-PKM-1 [cytosol] (R-HSA-9861692) PKM-1 [cytosol] (R-HSA-71667)	0.524	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.524	2
UniProt:Q15599 NHRF2			0.508	2
UniProt:Q03431 PTH1R	1	PTH1R [plasma membrane] (R-HSA-420479)	0.505	4
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.499	3
UniProt:P18146 EGR1	1	EGR1 [nucleoplasm] (R-HSA-1031703)	0.499	7
UniProt:Q9H6I2 SOX17	1	SOX17 [nucleoplasm] (R-HSA-5625834)	0.499	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.499	3
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.499	3
IntAct:EBI-6668710 TCF			0.499	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.499	2
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.499	2
UniProt:Q99569 PKP4	2	PKP4 [cornified envelope] (R-HSA-8847721) PKP4 [plasma membrane] (R-HSA-6814401)	0.491	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.483	3
UniProt:Q99697 PITX2	1	PITX2 [nucleoplasm] (R-HSA-8864726)	0.483	2
UniProt:Q9JHQ5	1	Lztfl1 [cytosol] (R-MMU-5617789)	0.471	2
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) NOS3 [cytosol] (R-HSA-202114)	0.471	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.463	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.463	3
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.463	2
UniProt:O95071 UBR5			0.463	6
UniProt:Q99593 TBX5	1	TBX5 [nucleoplasm] (R-HSA-2032786)	0.462	3

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