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FERMT2 [cytosol]
Stable Identifier
R-HSA-430275
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MIG-2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)
FERMT2 [cytosol] (Homo sapiens)
MIG-2:MIGFILIN [cytosol] (Homo sapiens)
FERMT2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
FERMT2 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
FERMT2 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
FERMT2 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
FERMT2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96AC1 FERMT2
Gene Names
FERMT2, KIND2, MIG2, PLEKHC1
Chain
chain:1-680
Reference Genes
BioGPS Gene:10979 FERMT2
COSMIC (genes):FERMT2 FERMT2
CTD Gene:10979 FERMT2
dbSNP Gene:10979 FERMT2
ENSEMBL:ENSG00000073712 FERMT2
HGNC:15767 FERMT2
KEGG:hsa:10979 FERMT2
Monarch:10979 FERMT2
NCBI Gene:10979 FERMT2
OMIM:607746 FERMT2
UCSC:Q96AC1 FERMT2
Reference Transcript
RefSeq:NM_001135000.1 FERMT2
RefSeq:NM_001134999.1 FERMT2
RefSeq:NM_006832.2 FERMT2
Other Identifiers
10979
11718179_a_at
11718180_s_at
11718181_s_at
11737221_a_at
16793067
209209_PM_s_at
209209_s_at
209210_PM_s_at
209210_s_at
214212_PM_x_at
214212_x_at
3376773
3564918
3564920
3564921
3564922
3564923
3564924
3564925
3564926
3564927
3564928
3564929
3564931
3564932
3564936
3564941
3564942
3564944
3564948
3564949
3564950
3564951
3564952
3564956
3564957
3564960
3564961
3564963
3564964
3564966
3564967
3564968
3564969
3564970
3564971
3564972
36577_at
71961_at
7979204
A_23_P88347
A_33_P3344477
A_33_P3344482
GE60378
GO:0001725
GO:0003013
GO:0003779
GO:0005178
GO:0005515
GO:0005547
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0005938
GO:0007155
GO:0007160
GO:0007179
GO:0007229
GO:0008092
GO:0008289
GO:0008360
GO:0009898
GO:0009986
GO:0010718
GO:0016055
GO:0019901
GO:0022604
GO:0030054
GO:0030335
GO:0031258
GO:0031674
GO:0033622
GO:0033625
GO:0034330
GO:0034334
GO:0034446
GO:0034713
GO:0035505
GO:0042995
GO:0043116
GO:0043226
GO:0043547
GO:0045599
GO:0045669
GO:0046332
GO:0048041
GO:0048856
GO:0051015
GO:0051496
GO:0051894
GO:0051897
GO:0060173
GO:0065003
GO:0070161
GO:0070374
GO:0072657
GO:1900026
GO:1900182
GO:1902414
GO:1902462
GO:1903691
HMNXSV003032031
HMNXSV003047592
Hs.75260.0.S1_3p_a_at
Hs.75260.1.S1_3p_a_at
ILMN_1695290
PH_hs_0023340
TC14001144.hg
TC14002011.hg
Z24725_at
g505032_3p_a_at
Participates
as a candidate of
RAC1 effectors [cytosol] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
as a component of
MIG-2:MIGFILIN [cytosol] (Homo sapiens)
as an input of
Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)
Inferred To
fermt2 [cytosol]
(Xenopus tropicalis)
Fermt2 [cytosol]
(Rattus norvegicus)
FERMT2 [cytosol]
(Bos taurus)
FERMT2 [cytosol]
(Canis familiaris)
FERMT2 [cytosol]
(Danio rerio)
FERMT2 [cytosol]
(Gallus gallus)
FERMT2 [cytosol]
(Mus musculus)
FERMT2 [cytosol]
(Sus scrofa)
unc-112 [cytosol]
(Caenorhabditis elegans)
Fit1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001128472.1
,
NP_001128471.1
,
NP_006823.1
ENSEMBL
ENST00000553373
,
ENSP00000378993
,
ENST00000399304
,
ENST00000341590
,
ENST00000395631
,
ENSP00000342858
,
ENST00000343279
,
ENSP00000451084
,
ENSP00000340391
,
ENSP00000382243
OpenTargets
ENSG00000073712
HPA
ENSG00000073712-FERMT2
PRO
Q96AC1
Pharos - Targets
Q96AC1
GlyGen
Q96AC1
HMDB Protein
HMDBP14135
PDB
6XTJ
,
6U4N
,
4F7H
,
2LGX
,
2LKO
,
2MSU
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.681
13
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.558
6
UniProt:Q6ZW61 BBS12
1
BBS12 [cytosol]
(R-HSA-5624082)
0.534
2
UniProt:A0A0H3NFP4 A0A0H3NFP4
0.471
2
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