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PKP4 [plasma membrane]
Stable Identifier
R-HSA-6814401
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plakophilin-4, PKP4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds effectors (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
RND1:GTP:RND1 effectors [plasma membrane] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
RND2 GTPase cycle (Homo sapiens)
RND2 binds effectors (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
RND2:GTP:RND2 effectors [plasma membrane] (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
RND3 GTPase cycle (Homo sapiens)
RND3 binds effectors (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
RND3:GTP:RND3 effectors [plasma membrane] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
PKP4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99569 PKP4
Gene Names
PKP4
Chain
chain:1-1192
Reference Genes
BioGPS Gene:8502 PKP4
COSMIC (genes):PKP4 PKP4
CTD Gene:8502 PKP4
dbSNP Gene:8502 PKP4
ENSEMBL:ENSG00000144283 PKP4
ENSEMBL:ENSG00000144283.23 PKP4
HGNC:9026 PKP4
KEGG Gene (Homo sapiens):8502 PKP4
Monarch:8502 PKP4
NCBI Gene:8502 PKP4
OMIM:604276 PKP4
UCSC:Q99569 PKP4
Reference Transcript
RefSeq:NM_001304969.1 PKP4
RefSeq:NM_001304970.1 PKP4
RefSeq:NM_003628.4 PKP4
RefSeq:XM_011512016.1 PKP4
RefSeq:NM_001005476.2 PKP4
Other Identifiers
11743914_a_at
11754620_s_at
11756270_x_at
11756548_s_at
16886757
201927_PM_s_at
201927_s_at
201928_PM_at
201928_at
201929_PM_s_at
201929_s_at
240379_PM_at
240379_at
2511825
2511826
2511861
2511876
2511889
2511897
2511898
2511901
2511906
2511907
2511908
2511909
2511910
2511911
2511920
2511921
2511922
2511930
2511931
2511932
2511940
2511941
2511942
2511945
2511951
2511952
2511957
2511958
2511961
2511970
2511973
2511974
2511975
2511976
2511977
2511978
2511979
2511993
2525495
3228006
39788_at
50254_at
64323_at
74806_s_at
78293_at
8045860
8502
A_14_P135068
A_14_P200730
A_33_P3288110
GE80528
GO:0000910
GO:0000922
GO:0001533
GO:0005515
GO:0005634
GO:0005737
GO:0005819
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0007043
GO:0007155
GO:0007267
GO:0009898
GO:0014069
GO:0016020
GO:0023052
GO:0030054
GO:0030057
GO:0030155
GO:0030496
GO:0032467
GO:0034330
GO:0043226
GO:0043547
GO:0044291
GO:0045296
GO:0048471
GO:0051233
GO:0070161
GO:0072686
GO:0098609
Hs.132860.0.A1_3p_at
Hs.152151.0.S1_3p_a_at
Hs.152151.0.S3_3p_at
ILMN_1661325
ILMN_1749410
PH_hs_0007967
PH_hs_0040438
TC02000960.hg
X81889_at
g6806894_3p_a_at
Participates
as a candidate of
RND2 effectors [cytosol] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
as a member of
Plakophilins [plasma membrane] (Homo sapiens)
Other forms of this molecule
PKP4 [cornified envelope]
Inferred To
Pkp4 [plasma membrane]
(Mus musculus)
Pkp4 [plasma membrane]
(Rattus norvegicus)
PKP4 [plasma membrane]
(Bos taurus)
PKP4 [plasma membrane]
(Canis familiaris)
PKP4 [plasma membrane]
(Danio rerio)
PKP4 [plasma membrane]
(Gallus gallus)
PKP4 [plasma membrane]
(Sus scrofa)
pkp4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001291899.1
,
NP_003619.2
,
NP_001291898.1
,
NP_001005476.1
,
XP_011510318.1
OpenTargets
ENSG00000144283
HPA
ENSG00000144283-PKP4
GeneCards
Q99569
Ensembl
ENSP00000374407
,
ENSP00000374409
,
ENST00000389759
,
ENSG00000144283
,
ENST00000389757
PRO
Q99569
Pharos - Targets
Q99569
Orphanet
27558
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.684
4
UniProt:Q96RT1 ERBIN
1
ERBIN [plasma membrane]
(R-HSA-1358718)
0.621
4
UniProt:Q12959 DLG1
4
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [plasma membrane]
(R-HSA-375977)
0.609
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
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