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PXLP-K119-CBS [cytosol]
Stable Identifier
R-HSA-1614563
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CBS, Cystathionine beta-synthase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)
PXLP-K119-CBS tetramer [cytosol] (Homo sapiens)
PXLP-K119-CBS [cytosol] (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Cysteine formation from homocysteine (Homo sapiens)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)
PXLP-K119-CBS tetramer [cytosol] (Homo sapiens)
PXLP-K119-CBS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35520 CBS
Gene Names
CBS
Chain
chain:1-551
Reference Genes
BioGPS Gene:102724560 CBS
BioGPS Gene:875 CBS
COSMIC (genes):CBS CBS
CTD Gene:875 CBS
dbSNP Gene:102724560 CBS
dbSNP Gene:875 CBS
ENSEMBL:ENSG00000160200 CBS
HGNC:1550 CBS
KEGG:hsa:102724560 CBS
KEGG:hsa:875 CBS
Monarch:102724560 CBS
Monarch:875 CBS
NCBI Gene:102724560 CBS
NCBI Gene:875 CBS
OMIM:613381 CBS
UCSC:P35520 CBS
Reference Transcript
RefSeq:NM_001321073.1 CBS
RefSeq:NM_001178008.2 CBS
RefSeq:XM_017028211.1 CBS
RefSeq:XM_011546098.1 CBS
RefSeq:XM_017028215.1 CBS
RefSeq:XM_017028492.1 CBS
RefSeq:XM_017028217.1 CBS
RefSeq:XM_017028213.1 CBS
RefSeq:XM_011546099.1 CBS
RefSeq:XM_011546095.2 CBS
RefSeq:XM_017028216.1 CBS
RefSeq:XM_017028214.1 CBS
RefSeq:XM_011546097.2 CBS
RefSeq:XM_011529782.1 CBS
RefSeq:XM_011529781.1 CBS
RefSeq:XM_017028491.1 CBS
RefSeq:XM_011529777.1 CBS
RefSeq:XM_011546094.1 CBS
RefSeq:NM_001320298.1 CBS
RefSeq:NM_000071.2 CBS
RefSeq:XM_017028489.1 CBS
RefSeq:NM_001178009.2 CBS
RefSeq:XM_017028212.1 CBS
RefSeq:XM_017028218.1 CBS
RefSeq:XM_017028490.1 CBS
Other Identifiers
102724560
11744285_a_at
11744286_s_at
11744287_x_at
11744835_s_at
11745019_a_at
11752656_a_at
1553972_PM_a_at
1553972_a_at
16926111
212816_PM_s_at
212816_s_at
38474_at
3933924
3933925
3933926
3933927
3933928
3933929
3933930
3933932
3933939
3933940
3933941
3933942
3933943
3933945
3933946
3933947
3933948
3933950
3933951
3933952
3933953
3933954
3933955
3933956
3933957
3933958
3933959
3933960
3933961
3933962
3933965
3933966
3933967
3933968
3933969
3933970
3933971
3933972
3933973
3933974
3933975
3933976
3933977
3933979
78890_at
8070632
875
A_23_P166306
A_24_P48856
GE57544
GO:0001958
GO:0001974
GO:0003013
GO:0003824
GO:0004122
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006520
GO:0006534
GO:0006535
GO:0006563
GO:0006565
GO:0006790
GO:0006801
GO:0009069
GO:0010749
GO:0016491
GO:0016829
GO:0019343
GO:0019344
GO:0019346
GO:0019448
GO:0019825
GO:0019899
GO:0020037
GO:0021587
GO:0022414
GO:0030170
GO:0031625
GO:0031667
GO:0042262
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043418
GO:0044272
GO:0046872
GO:0048856
GO:0050421
GO:0050667
GO:0051593
GO:0060135
GO:0060351
GO:0070025
GO:0070026
GO:0070814
GO:0071456
GO:0072341
GO:0097746
GO:1904047
HMNXSV003006773
HMNXSV003012529
Hs.84152.2.S1_3p_s_at
ILMN_1804735
L00972_at
PH_hs_0022824
Participates
as a component of
PXLP-K119-CBS tetramer [cytosol] (Homo sapiens)
Inferred To
CBS [cytosol]
(Bos taurus)
CBS [cytosol]
(Canis familiaris)
CBS [cytosol]
(Sus scrofa)
cbsb [cytosol]
(Danio rerio)
PXLP-K119-CBS [cytosol]
(Caenorhabditis elegans)
PXLP-K119-CBS [cytosol]
(Dictyostelium discoideum)
PXLP-K119-CBS [cytosol]
(Drosophila melanogaster)
PXLP-K119-CBS [cytosol]
(Gallus gallus)
PXLP-K119-CBS [cytosol]
(Mus musculus)
PXLP-K119-CBS [cytosol]
(Rattus norvegicus)
PXLP-K119-CBS [cytosol]
(Saccharomyces cerevisiae)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 119
Coordinate
119
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
Guide to Pharmacology - Targets
1443
OpenTargets
ENSG00000160200
ENSEMBL
ENST00000398165
,
ENSP00000381231
,
ENST00000359624
,
ENST00000352178
,
ENSP00000344460
,
ENSP00000352643
,
ENSP00000381225
,
ENST00000398158
HPA
ENSG00000160200-CBS
ZINC - Substances
CBS_HUMAN
ZINC target
P35520
PRO
P35520
Pharos - Targets
P35520
Orphanet
CBS
GlyGen
P35520
HMDB Protein
HMDBP00779
PDB
4UUU
,
1M54
,
4L0D
,
8S5H
,
8S5M
,
8S5K
,
7QGT
,
8S5L
,
8S5J
,
4PCU
,
1JBQ
,
4L3V
,
4COO
,
8S5I
,
4L27
,
4L28
,
8STW
,
5MMS
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.666
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.666
4
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.666
4
UniProt:O75344 FKBP6
2
FKBP6 [nucleoplasm]
(R-HSA-912512)
FKBP6 [cytosol]
(R-HSA-5601923)
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [cytosol]
(R-HSA-57844)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:P22466 GAL
1
GAL [extracellular region]
(R-HSA-389038)
0.556
3
UniProt:O75928-2 PIAS2
1
PIAS2-2 [nucleoplasm]
(R-HSA-2993779)
0.556
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.556
3
UniProt:P06241 FYN
6
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
0.556
3
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