Reactome | 3xUb-p-S927,S932-NFKB1(1-968) [cytosol]

3xUb-p-S927,S932-NFKB1(1-968) [cytosol]

Stable Identifier

R-HSA-451619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3xUb-p-S927,S932-NFKB1, Ub-p-NFkB1 p105, Nuclear factor NF-kappa-B p105 subunit

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External Reference Information

External Reference

UniProt:P19838 NFKB1

Gene Names

NFKB1

Chain

chain:1-968, chain:1-433

Reference Genes

BioGPS Gene:4790 NFKB1

COSMIC (genes):NFKB1 NFKB1

CTD Gene:4790 NFKB1

dbSNP Gene:4790 NFKB1

ENSEMBL:ENSG00000109320 NFKB1

HGNC:7794 NFKB1

KEGG:hsa:4790 NFKB1

Monarch:4790 NFKB1

NCBI Gene:4790 NFKB1

OMIM:164011 NFKB1

UCSC:P19838 NFKB1

Reference Transcript

Participates

as a component of

3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)

This entity regulates

Negatively

NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)

Other forms of this molecule

p-S927,S932-NFKB1(1-968) [cytosol]

NFKB1(1-968) [cytosol]

NFKB1(1-433) [nucleoplasm]

NFKB1(1-433) [cytosol]

NFKB1(1-968) [secretory granule lumen]

NFKB1(1-968) [extracellular region]

NFKB1(1-968) [specific granule lumen]

Inferred To

phospho-NFKB1 [cytosol] (Bos taurus)

phospho-NFKB1 [cytosol] (Canis familiaris)

phospho-NFKB1 [cytosol] (Gallus gallus)

phospho-NFKB1 [cytosol] (Sus scrofa)

phospho-nfkb1 [cytosol] (Xenopus tropicalis)

phospho-Nfkb1 [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 927

Coordinate

927

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 932

Coordinate

932

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003989.2, NP_001158884.1, NP_001306155.1

Guide to Pharmacology - Targets

3281

OpenTargets

ENSG00000109320

ENSEMBL

ENST00000394820, ENSP00000378297, ENSP00000424790, ENST00000509165, ENSG00000109320, ENST00000505458, ENST00000226574, ENSP00000226574, ENSP00000423877

ZINC - Substances

NFKB1_HUMAN

ZINC - Biogenic

NFKB1_HUMAN

ZINC target

P19838

PRO

P19838

GlyGen

P19838

PDB

1MDI, 1MDJ, 1MDK, 8TQD, 7RG4, 7LF4, 2DBF, 2O61, 1SVC, 3GUT, 7LET, 7LFC, 1NFI, 7RG5, 7LEQ

ZINC - Metabolites

NFKB1_HUMAN

GeneCards

NFKB1

HPA

ENSG00000109320-NFKB1

Pharos - Targets

P19838

Orphanet

NFKB1

ZINC - Predictions - Purchasable

NFKB1_HUMAN

HMDB Protein

HMDBP02145

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.933	11
UniProt:P41279 MAP3K8	3	p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259) MAP3K8 [cytosol] (R-HSA-389388) p-S400-MAP3K8 [cytosol] (R-HSA-389738)	0.927	14
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.924	16
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.865	8
UniProt:Q00653 NFKB2	6	NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) p-7S-p100 [cytosol] (R-HSA-5607629) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) NFKB2(1-900) [cytosol] (R-HSA-2677931) monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500)	0.823	10
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.816	10
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.779	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.773	4
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557)	0.764	7
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.763	6
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.744	7
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.725	6
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.695	4
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.689	7
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972)	0.689	5
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.646	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.646	5
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.623	5
IntAct:EBI-9870239 IKK			0.623	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.615	3
UniProt:O00221 NFKBIE	3	NFKBIE [cytosol] (R-HSA-1168580) p-S157,S161-NFKBIE [cytosol] (R-HSA-1168561) p-S157,S161-Ub-NFKBIE [cytosol] (R-HSA-1168563)	0.604	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.597	5
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.597	5
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.547	2
UniProt:P14921 ETS1	2	p-T38-ETS1 [nucleoplasm] (R-HSA-3132720) ETS1 [nucleoplasm] (R-HSA-1629809)	0.536	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	3
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.527	2
UniProt:Q8IV08 PLD3	2	PLD3 [plasma membrane] (R-HSA-2029042) PLD3 [endoplasmic reticulum membrane] (R-HSA-1498798)	0.524	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.524	2
UniProt:P10226 PAP			0.524	4
UniProt:Q92887 ABCC2	5	ABCC2 R768W [plasma membrane] (R-HSA-5679033) ABCC2 R1066* [plasma membrane] (R-HSA-5679021) ABCC2 R1150H [plasma membrane] (R-HSA-5679024) ABCC2 I1173F [plasma membrane] (R-HSA-5679030) ABCC2 [plasma membrane] (R-HSA-375571)	0.508	3
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.508	2
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.483	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.483	3
UniProt:Q9BQI6 SLF1			0.483	2
UniProt:P08563-PRO_0000041302			0.463	2

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