Reactome | 3xUb-p-S927,S932-NFKB1(1-968) [cytosol]

3xUb-p-S927,S932-NFKB1(1-968) [cytosol]

Stable Identifier

R-HSA-451619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3xUb-p-S927,S932-NFKB1, Ub-p-NFkB1 p105, Nuclear factor NF-kappa-B p105 subunit

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External Reference Information

External Reference

UniProt:P19838 NFKB1

Gene Names

NFKB1

Chain

chain:1-968, chain:1-433

Reference Genes

BioGPS Gene:4790 NFKB1

COSMIC (genes):NFKB1 NFKB1

CTD Gene:4790 NFKB1

dbSNP Gene:4790 NFKB1

ENSEMBL:ENSG00000109320 NFKB1

ENSEMBL:ENSG00000109320.14 NFKB1

HGNC:7794 NFKB1

KEGG Gene (Homo sapiens):4790 NFKB1

Monarch:4790 NFKB1

NCBI Gene:4790 NFKB1

OMIM:164011 NFKB1

UCSC:P19838 NFKB1

Reference Transcript

Other Identifiers

11717542_a_at

1377_at

1378_g_at

16969300

209239_PM_at

209239_at

2737731

2737732

2737737

2737740

2737743

2737745

2737753

2737756

2737759

2737762

2737763

2737765

2737770

2737771

2737772

2737773

2737775

2737776

2737781

2737783

2737784

2737789

2737790

2737791

2737793

2737796

2737797

38438_at

4790

8096635

A_14_P115699

A_23_P30024

GE57992

GO:0000122

GO:0000165

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001818

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0003712

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006629

GO:0006766

GO:0006915

GO:0006954

GO:0007165

GO:0007249

GO:0007254

GO:0008092

GO:0010467

GO:0010468

GO:0010629

GO:0010744

GO:0010884

GO:0010956

GO:0010957

GO:0012501

GO:0023052

GO:0030154

GO:0031410

GO:0032375

GO:0032695

GO:0033256

GO:0034097

GO:0034774

GO:0035580

GO:0035994

GO:0038061

GO:0042802

GO:0042805

GO:0043066

GO:0043226

GO:0043565

GO:0045087

GO:0045892

GO:0045893

GO:0045944

GO:0048856

GO:0050728

GO:0050853

GO:0051248

GO:0060056

GO:0060261

GO:0071222

GO:0071260

GO:0071316

GO:0071347

GO:0071354

GO:0071356

GO:0071359

GO:0090263

GO:0097398

GO:0098542

GO:0098586

GO:0140110

GO:1900127

GO:1901135

GO:1904385

GO:2000630

HMNXSV003038926

ILMN_1714965

M58603_at

PH_hs_0022751

TC04000526.hg

g189179_3p_at

Participates

as a component of

3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)

This entity regulates

Negatively

NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)

Other forms of this molecule

NFKB1(1-968) [secretory granule lumen]

NFKB1(1-968) [extracellular region]

NFKB1(1-968) [specific granule lumen]

NFKB1(1-433) [cytosol]

NFKB1(1-433) [nucleoplasm]

NFKB1(1-968) [cytosol]

p-S927,S932-NFKB1(1-968) [cytosol]

Inferred To

phospho-ccdc71l [cytosol] (Xenopus tropicalis)

phospho-NFKB1 [cytosol] (Bos taurus)

phospho-NFKB1 [cytosol] (Gallus gallus)

phospho-NFKB1 [cytosol] (Sus scrofa)

phospho-Nfkb1 [cytosol] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 927

Coordinate

927

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 932

Coordinate

932

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001158884.1, NP_003989.2, NP_001306155.1

OpenTargets

ENSG00000109320

ZINC - Substances

NFKB1_HUMAN

ZINC - Biogenic

NFKB1_HUMAN

ZINC target

P19838

PRO

P19838

PDB

1SVC, 3GUT, 1MDJ, 1MDK, 7LET, 7LF4, 2DBF, 7RG5, 1NFI, 2O61, 1MDI, 7LEQ, 7RG4, 7LFC

ZINC - Metabolites

NFKB1_HUMAN

GeneCards

P19838

HPA

ENSG00000109320-NFKB1

Ensembl

ENSP00000226574, ENSP00000423877, ENST00000226574, ENST00000394820, ENSP00000378297, ENST00000505458, ENSG00000109320, ENSP00000424790, ENST00000509165

Pharos - Targets

P19838

ZINC - Predictions - Purchasable

NFKB1_HUMAN

Orphanet

23358

HMDB Protein

HMDBP02145

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41279 MAP3K8	3	p-S400-MAP3K8 [cytosol] (R-HSA-389738) MAP3K8 [cytosol] (R-HSA-389388) p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259)	0.927	14
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846)	0.919	9
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.916	14
UniProt:Q00653 NFKB2	6	monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500) NFKB2(1-900) [cytosol] (R-HSA-2677931) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) p-7S-p100 [cytosol] (R-HSA-5607629) NFKB2(1-454) [cytosol] (R-HSA-168144) NFKB2(1-454) [nucleoplasm] (R-HSA-177674)	0.772	8
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.772	5
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.764	7
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.744	7
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.713	3
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.706	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.695	7
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.695	4
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972)	0.689	5
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.689	7
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.646	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.646	5
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.64	5
IntAct:EBI-9870239 IKK			0.623	2
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.623	5
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.604	3
UniProt:O00221 NFKBIE	3	p-S157,S161-Ub-NFKBIE [cytosol] (R-HSA-1168563) NFKBIE [cytosol] (R-HSA-1168580) p-S157,S161-NFKBIE [cytosol] (R-HSA-1168561)	0.604	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.547	2
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.536	2
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.527	2
UniProt:P10226 PAP			0.524	4
UniProt:Q8IV08 PLD3	2	PLD3 [endoplasmic reticulum membrane] (R-HSA-1498798) PLD3 [plasma membrane] (R-HSA-2029042)	0.524	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.524	2
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.508	2
UniProt:Q92887 ABCC2	5	ABCC2 R768W [plasma membrane] (R-HSA-5679033) ABCC2 R1066* [plasma membrane] (R-HSA-5679021) ABCC2 R1150H [plasma membrane] (R-HSA-5679024) ABCC2 I1173F [plasma membrane] (R-HSA-5679030) ABCC2 [plasma membrane] (R-HSA-375571)	0.508	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.483	2
UniProt:P34931 HSPA1L	2	HSPA1L [cytosol] (R-HSA-3371410) HSPA1L [nucleoplasm] (R-HSA-5082367)	0.483	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.483	3
UniProt:Q9BQI6 SLF1			0.483	2
UniProt:P08563-PRO_0000041302			0.463	2
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.462	4
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.462	4

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