Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PKM-1 [cytosol]
Stable Identifier
R-HSA-71667
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PKM isozyme M2, pyruvate kinase, M2 isozyme
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)
pyruvate kinase tetramer [cytosol] (Homo sapiens)
pyruvate kinase M2 complex [cytosol] (Homo sapiens)
PKM-1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14618-1 PKM
Gene Names
PKM, OIP3, PK2, PK3, PKM2
Other Identifiers
0002030537
0006200152
0006510452
11722787_a_at
11752165_s_at
11752166_x_at
11752342_x_at
11752458_a_at
11756971_x_at
16811372
201251_PM_at
201251_at
2893336
2893342
3103883
3103886
3103891
3103895
32378_at
3631965
3631966
3631967
3631968
3631969
3631971
3631977
3631984
3631989
3631992
3631993
3631998
3631999
3632000
3632003
3632005
3632007
3632010
3632011
3632029
3632030
3632031
3632032
3632033
3632034
3632035
3632036
3979839
5315
7990151
A_23_P399501
A_32_P147241
GE81173
GO:0000166
GO:0000287
GO:0002181
GO:0003723
GO:0003729
GO:0003824
GO:0004713
GO:0004743
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005791
GO:0005829
GO:0005929
GO:0005975
GO:0006091
GO:0006096
GO:0006417
GO:0008152
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0023026
GO:0030312
GO:0030955
GO:0031012
GO:0031410
GO:0031982
GO:0032869
GO:0034774
GO:0036211
GO:0043226
GO:0045296
GO:0046872
GO:0048856
GO:0055086
GO:0061621
GO:0062023
GO:0070062
GO:0140096
GO:1901135
GO:1903561
GO:1903672
GO:1904813
GO:2000767
HMNXSV003020043
ILMN_1663122
ILMN_1672650
ILMN_1775327
ILMN_2366634
PH_hs_0029415
TC15002609.hg
TC15002610.hg
TC15002776.hg
X56494_at
g4505838_3p_at
g4505838_3p_x_at
Participates
as a component of
pyruvate kinase M2 complex [cytosol] (Homo sapiens)
Inferred To
Dmel\CG7362 [cytosol]
(Drosophila melanogaster)
pkm [cytosol]
(Xenopus tropicalis)
PKM-2 [cytosol]
(Danio rerio)
PKM-2 [cytosol]
(Dictyostelium discoideum)
PKM-2 [cytosol]
(Drosophila melanogaster)
PKM-2 [cytosol]
(Gallus gallus)
PKM-2 [cytosol]
(Mus musculus)
PKM-2 [cytosol]
(Plasmodium falciparum)
PKM-2 [cytosol]
(Saccharomyces cerevisiae)
PKM-2 [cytosol]
(Schizosaccharomyces pombe)
Dmel\CG2964 [cytosol]
(Drosophila melanogaster)
pyk-2 [cytosol]
(Caenorhabditis elegans)
PKM [cytosol]
(Bos taurus)
PKM [cytosol]
(Sus scrofa)
Dmel\CG12229 [cytosol]
(Drosophila melanogaster)
Dmel\CG7069 [cytosol]
(Drosophila melanogaster)
Homologues of PKM-2 [cytosol]
(Caenorhabditis elegans)
Homologues of PKM-2 [cytosol]
(Danio rerio)
Homologues of PKM-2 [cytosol]
(Drosophila melanogaster)
Homologues of PKM-2 [cytosol]
(Plasmodium falciparum)
Homologues of PKM-2 [cytosol]
(Saccharomyces cerevisiae)
pyk-1 [cytosol]
(Caenorhabditis elegans)
LOC100362738 [cytosol]
(Rattus norvegicus)
Dmel\CG11249 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_872271.1
,
NP_002645.3
,
XP_016877802.1
,
XP_005254502.1
,
NP_001193725.1
,
NP_872270.1
,
NP_001193726.1
,
NP_001193727.1
,
NP_001303247.1
,
NP_001193728.1
Guide to Pharmacology - Targets
3006
OpenTargets
ENSG00000067225
ZINC - Substances
KPYM_HUMAN
ZINC - Biogenic
KPYM_HUMAN
ZINC target
P14618
PRO
P14618
PDB
6NU5
,
6TTQ
,
6B6U
,
6V76
,
5X1V
,
6TTF
,
4FXJ
,
6WP3
,
4B2D
,
6WP4
,
5X0I
,
6TTH
,
3SRF
,
5X1W
,
3BJT
,
6JFB
,
4QGC
,
3SRH
,
6WP6
,
6TTI
,
6NU1
,
6V74
,
4FXF
,
3G2G
,
4WJ8
,
6GG3
,
4QG6
,
4RPP
,
3BJF
,
6WP5
,
4YJ5
,
4QG8
,
3SRD
,
4QG9
,
6GG4
,
7L21
,
1ZJH
,
4JPG
,
6GG5
,
4G1N
,
3GQY
,
3U2Z
,
3GR4
,
3H6O
,
3ME3
,
6NUB
,
6GG6
,
6V75
,
1T5A
ZINC - Metabolites
KPYM_HUMAN
IntEnz
2.7.10.2
HPA
ENSG00000067225-PKM
GeneCards
P14618
Ensembl
ENSP00000334983
,
ENST00000335181
,
ENSG00000067225
,
ENST00000319622
,
ENSP00000456970
,
ENSP00000320171
,
ENST00000568459
Pharos - Targets
P14618
ZINC - Predictions - Purchasable
KPYM_HUMAN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
9
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.524
4
UniProt:P49407 ARRB1
5
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
UniProt:P32121 ARRB2
2
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
0.499
4
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text