Reactome | CUL3 [nucleoplasm]

CUL3 [nucleoplasm]

Stable Identifier

R-HSA-5635033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cullin-3, CUL3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13618 CUL3

Gene Names

CUL3, KIAA0617

Chain

initiator methionine:1, chain:2-768

Reference Genes

BioGPS Gene:8452 CUL3

COSMIC (genes):CUL3 CUL3

CTD Gene:8452 CUL3

dbSNP Gene:8452 CUL3

ENSEMBL:ENSG00000036257 CUL3

HGNC:2553 CUL3

KEGG Gene (Homo sapiens):8452 CUL3

Monarch:8452 CUL3

NCBI Gene:8452 CUL3

OMIM:603136 CUL3

UCSC:Q13618 CUL3

Reference Transcript

Other Identifiers

0002470711

0002680050

11716505_a_at

11716506_s_at

11716507_at

11716508_at

16909049

201370_s_at

201371_s_at

201372_s_at

2601552

2601553

2601554

2601555

2601556

2601557

2601560

2601562

2601570

2601571

2601573

2601577

2601579

2601581

2601582

2601584

2601585

2601587

2601589

2601601

2601607

2601610

2601615

2601616

37702_at

8059393

8452

A_23_P209288

A_24_P140030

A_33_P3321150

GE53336

GO:0000082

GO:0000122

GO:0000165

GO:0000209

GO:0000278

GO:0000902

GO:0000922

GO:0001701

GO:0001831

GO:0003674

GO:0004842

GO:0005112

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005827

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0006357

GO:0006464

GO:0006511

GO:0006513

GO:0006810

GO:0006888

GO:0006950

GO:0007010

GO:0007049

GO:0007059

GO:0007080

GO:0007165

GO:0007229

GO:0007267

GO:0007369

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009056

GO:0009058

GO:0009790

GO:0016020

GO:0016055

GO:0016192

GO:0016477

GO:0016567

GO:0017145

GO:0019899

GO:0022607

GO:0030030

GO:0030154

GO:0030332

GO:0031145

GO:0031208

GO:0031398

GO:0031461

GO:0031463

GO:0031514

GO:0031625

GO:0031648

GO:0032467

GO:0032991

GO:0034641

GO:0035024

GO:0036126

GO:0040011

GO:0040016

GO:0042995

GO:0043149

GO:0043161

GO:0043226

GO:0043687

GO:0044346

GO:0045842

GO:0048208

GO:0048646

GO:0048856

GO:0048870

GO:0051276

GO:0051301

GO:0051865

GO:0061024

GO:0061630

GO:0065003

GO:0070062

GO:0070936

GO:0071630

GO:0072576

GO:0072686

GO:0090090

GO:0097193

GO:0140014

GO:1901992

HMNXSV003004059

Hs.78946.0.A2_3p_a_at

ILMN_1653670

PH_hs_0004555

TC02002826.hg

U58089_at

g3139078_3p_a_at

g4503164_3p_a_at

Participates

as a component of

SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

G76-NEDD8-K712-CUL3 [cytosol]

CUL3 [cytosol]

Inferred To

Ghost homologue of CUL3 [nucleoplasm] (Bos taurus)

cul3b [nucleoplasm] (Danio rerio)

CUL3 [nucleoplasm] (Canis familiaris)

CUL3 [nucleoplasm] (Gallus gallus)

CUL3 [nucleoplasm] (Sus scrofa)

culC [nucleoplasm] (Dictyostelium discoideum)

Cul3 [nucleoplasm] (Drosophila melanogaster)

Cul3 [nucleoplasm] (Mus musculus)

Cul3 [nucleoplasm] (Rattus norvegicus)

cul-3 [nucleoplasm] (Caenorhabditis elegans)

cul3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003581.1, NP_001244127.1, NP_001244126.1

OpenTargets

ENSG00000036257

HPA

ENSG00000036257-CUL3

GeneCards

Q13618

Ensembl

ENSP00000386525, ENSP00000264414, ENSP00000387200, ENST00000264414, ENSP00000343601, ENST00000344951, ENST00000409096, ENSG00000036257, ENST00000409777

PRO

Q13618

Pharos - Targets

Q13618

Orphanet

21177

PDB

4AP2, 2MYL, 6I2M, 2MYM, 5NLB, 4HXI, 4EOZ, 4APF

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.83	11
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.641	3
UniProt:Q86VP6 CAND1	5	CAND1 [extracellular region] (R-HSA-6806498) CAND1 [cytosol] (R-HSA-5691146) CAND1 [nucleoplasm] (R-HSA-8955089) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399)	0.623	6
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.623	6
UniProt:Q14790 CASP8	8	CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [cytosol] (R-HSA-76158)	0.602	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.547	3
UniProt:Q15084 PDIA6	3	p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.527	2
UniProt:P55265 ADAR	1	ADAR [nucleoplasm] (R-HSA-53939)	0.527	2
UniProt:Q15843 NEDD8	17	K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8 [nucleoplasm] (R-HSA-8955926) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) NEDD8 [cytosol] (R-HSA-416969) NEDD8(1-88) [cytosol] (R-HSA-5690794) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8(77-88) [cytosol] (R-HSA-6782654) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526)	0.527	7
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	2
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.527	2
UniProt:Q8IWE4 DCUN1D3	2	DCUN1D3 [cytosol] (R-HSA-8951782) MyrG-DCUN1D3 [plasma membrane] (R-HSA-8956204)	0.499	2

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