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CUL3 [nucleoplasm]
Stable Identifier
R-HSA-5635033
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-3, CUL3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
CUL3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13618 CUL3
Gene Names
CUL3, KIAA0617
Chain
initiator methionine:, chain:2-768
Reference Genes
BioGPS Gene:8452 CUL3
COSMIC (genes):CUL3 CUL3
CTD Gene:8452 CUL3
dbSNP Gene:8452 CUL3
ENSEMBL:ENSG00000036257 CUL3
HGNC:2553 CUL3
KEGG:hsa:8452 CUL3
Monarch:8452 CUL3
NCBI Gene:8452 CUL3
OMIM:603136 CUL3
UCSC:Q13618 CUL3
Reference Transcript
RefSeq:NM_001257197.1 CUL3
RefSeq:NM_001257198.1 CUL3
RefSeq:NM_003590.4 CUL3
Participates
as a component of
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CUL3 [cytosol]
G76-NEDD8-K712-CUL3 [cytosol]
Inferred To
cul3b [nucleoplasm]
(Danio rerio)
CUL3 [nucleoplasm]
(Bos taurus)
CUL3 [nucleoplasm]
(Canis familiaris)
CUL3 [nucleoplasm]
(Gallus gallus)
CUL3 [nucleoplasm]
(Sus scrofa)
culC [nucleoplasm]
(Dictyostelium discoideum)
Cul3 [nucleoplasm]
(Drosophila melanogaster)
Cul3 [nucleoplasm]
(Mus musculus)
Cul3 [nucleoplasm]
(Rattus norvegicus)
cul-3 [nucleoplasm]
(Caenorhabditis elegans)
cul3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000036257
ENSEMBL
ENST00000409777
,
ENSP00000386525
,
ENST00000409096
,
ENST00000264414
,
ENSP00000264414
,
ENST00000344951
,
ENSP00000343601
,
ENSG00000036257
,
ENSP00000387200
GeneCards
CUL3
HPA
ENSG00000036257-CUL3
PRO
Q13618
Pharos - Targets
Q13618
GlyGen
Q13618
Orphanet
CUL3
HMDB Protein
HMDBP12790
PDB
8H35
,
8H37
,
8H33
,
8H36
,
4EOZ
,
8I79
,
6I2M
,
2MYM
,
2MYL
,
8H34
,
4AP2
,
8K8T
,
5NLB
,
8U82
,
8U80
,
8H38
,
8U84
,
4HXI
,
4APF
,
8H3F
,
8H3A
,
8K9I
,
8H3R
,
8U81
,
8U83
,
8H3Q
,
8KHP
,
8GQ6
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.871
13
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.819
7
UniProt:Q86VP6 CAND1
5
CAND1 [cytosol]
(R-HSA-5691146)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
0.748
8
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
NEDD8 [cytosol]
(R-HSA-416969)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
0.725
9
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.723
4
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.666
5
UniProt:O94955 RHOBTB3
1
RHOBTB3 [trans-Golgi network membrane]
(R-HSA-6813908)
0.643
4
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.623
6
UniProt:Q14790 CASP8
8
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
0.602
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q15369 ELOC
2
ELOC [cytosol]
(R-HSA-180535)
TCEB1 [nucleoplasm]
(R-HSA-112422)
0.547
3
UniProt:Q96GD4 AURKB
3
AURKB [cytosol]
(R-HSA-174231)
AURKB [nucleoplasm]
(R-HSA-4655360)
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.527
2
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.527
2
UniProt:O43143 DHX15
1
DHX15 [nucleoplasm]
(R-HSA-5688097)
0.527
2
UniProt:P06733 ENO1
1
ENO1 [cytosol]
(R-HSA-71437)
0.527
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.527
2
UniProt:Q8IY81 FTSJ3
1
FTSJ3 [nucleoplasm]
(R-HSA-6791507)
0.527
2
UniProt:P07437 TUBB
3
TUBB [extracellular region]
(R-HSA-380317)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
0.527
2
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.527
2
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.527
2
UniProt:Q13427 PPIG
2
PPIG [nucleoplasm]
(R-HSA-9769592)
PPIG [cytosol]
(R-HSA-9728768)
0.527
2
UniProt:P78527 PRKDC
4
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.527
2
UniProt:Q15084 PDIA6
3
PDIA6 [endoplasmic reticulum lumen]
(R-HSA-3009049)
p-PDIA6 [endoplasmic reticulum lumen]
(R-HSA-8957031)
PDIA6 [endoplasmic reticulum membrane]
(R-HSA-535530)
0.527
2
UniProt:P62937 PPIA
5
PPIA [cytosol]
(R-HSA-173123)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular exosome]
(R-HSA-6801538)
0.527
2
UniProt:P07737 PFN1
2
PFN1 [cytosol]
(R-HSA-203081)
PFN1 [extracellular region]
(R-HSA-350755)
0.527
2
UniProt:P55265 ADAR
2
ADAR1 [cytosol]
(R-HSA-9835955)
ADAR [nucleoplasm]
(R-HSA-53939)
0.527
2
UniProt:Q9BYZ6 RHOBTB2
1
RHOBTB2 [endosome membrane]
(R-HSA-194907)
0.527
2
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.527
4
UniProt:O94844 RHOBTB1
1
RHOBTB1 [endosome membrane]
(R-HSA-194899)
0.527
5
UniProt:P22314 UBA1
2
UBA1 [cytosol]
(R-HSA-947698)
UBA1 [nucleoplasm]
(R-HSA-8852116)
0.527
2
UniProt:Q8IWE4 DCUN1D3
2
MyrG-DCUN1D3 [plasma membrane]
(R-HSA-8956204)
DCUN1D3 [cytosol]
(R-HSA-8951782)
0.499
2
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