Reactome | TCF7L2 [nucleoplasm]

TCF7L2 [nucleoplasm]

Stable Identifier

R-HSA-201923

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TCF7L2 (TCF4), hTCF-4_1

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Peptide hormone metabolism (Homo sapiens)
  - Incretin synthesis, secretion, and inactivation (Homo sapiens)
    - Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
      - Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)
        
        hTCF-4:Beta-catenin [nucleoplasm] (Homo sapiens)
        
        hTCF-4 [nucleoplasm] (Homo sapiens)
        
        TCF7L2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NQB0 TCF7L2

Gene Names

TCF7L2, TCF4

Chain

chain:1-619

Reference Genes

BioGPS Gene:6934 TCF7L2

COSMIC (genes):TCF7L2 TCF7L2

CTD Gene:6934 TCF7L2

dbSNP Gene:6934 TCF7L2

ENSEMBL:ENSG00000148737 TCF7L2

ENSEMBL_homo_sapiens_GENE:ENSG00000148737.18 TCF7L2

HGNC:11641 TCF7L2

KEGG Gene (Homo sapiens):6934 TCF7L2

Monarch:6934 TCF7L2

NCBI Gene:6934 TCF7L2

OMIM:602228 TCF7L2

UCSC:Q9NQB0 TCF7L2

Reference Transcript

Other Identifiers

11746313_a_at

11746314_s_at

11746315_x_at

11746404_a_at

11747829_x_at

11751102_x_at

11755181_a_at

16709333

212759_PM_s_at

212759_s_at

212761_PM_at

212761_at

212762_PM_s_at

212762_s_at

216035_PM_x_at

216035_x_at

216037_PM_x_at

216037_x_at

216511_PM_s_at

216511_s_at

32025_at

3264622

3264623

3264624

3264626

3264627

3264633

3264652

3264659

3264685

3264689

3264692

3264696

3264697

3264698

3264699

3264708

3264710

3264712

3264714

3264722

3264723

3264724

3264725

3264726

48528_at

6934

7930537

A_14_P125103

A_14_P133398

A_23_P127013

A_23_P389588

A_24_P921823

A_33_P3377304

GE83165

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001568

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005975

GO:0006351

GO:0006355

GO:0006357

GO:0006790

GO:0008013

GO:0009749

GO:0010718

GO:0010909

GO:0012501

GO:0016055

GO:0016605

GO:0016922

GO:0019901

GO:0023052

GO:0030154

GO:0031016

GO:0032024

GO:0032092

GO:0032350

GO:0032993

GO:0042593

GO:0043226

GO:0043433

GO:0043565

GO:0043570

GO:0045295

GO:0045444

GO:0045721

GO:0045892

GO:0045944

GO:0048625

GO:0048660

GO:0048856

GO:0050679

GO:0051897

GO:0060070

GO:0061629

GO:0070016

GO:0070369

GO:0071664

GO:0090090

GO:0140110

GO:1900182

GO:1901135

GO:1990841

GO:1990907

GO:2000675

GO:2001237

HMNXSV003004532

HMNXSV003007299

HMNXSV003057192

Hs.173638.0.S1_3p_s_at

Hs.173638.0.S2_3p_s_at

Hs.173638.0.S3_3p_a_at

Hs.173638.0.S3_3p_at

Hs.173638.1.S1_3p_x_at

Hs.173638.2.S1_3p_a_at

Hs.173638.2.S1_3p_x_at

Hs.283857.0.S1_3p_s_at

ILMN_1672486

TC10000820.hg

TC10002300.hg

Y11306_rna1_at

Participates

as a component of

TCF7L2:CTNNB1 [nucleoplasm] (Homo sapiens)

as a member of

as a candidate of

TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TCF7L2 K485fs*25 [nucleoplasm]

TCF7L2 R397W [nucleoplasm]

pT201,T212-TCF7L2 [nucleoplasm]

Inferred To

pan [nucleoplasm] (Drosophila melanogaster)

TCF7L2 [nucleoplasm] (Bos taurus)

TCF7L2 [nucleoplasm] (Canis familiaris)

TCF7L2 [nucleoplasm] (Gallus gallus)

TCF7L2 [nucleoplasm] (Sus scrofa)

Tcf7l2 [nucleoplasm] (Mus musculus)

Tcf7l2 [nucleoplasm] (Rattus norvegicus)

pop-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001139758.1, NP_001185457.1, XP_016872081.1, XP_005270153.1, NP_001139756.1, NP_001185460.1, NP_001139746.1, XP_005270146.1, XP_016872082.1, NP_001185455.1, NP_001139755.1, XP_005270141.1, XP_005270160.1

OpenTargets

ENSG00000148737

GeneCards

Q9NQB0

HPA

ENSG00000148737-TCF7L2

Ensembl

ENST00000352065, ENSP00000347949, ENST00000355995, ENSP00000344823, ENSG00000148737, ENSP00000446172, ENST00000355717, ENSP00000486891, ENST00000627217, ENST00000369397, ENST00000538897, ENSP00000358404, ENSP00000348274

PRO

Q9NQB0

Pharos - Targets

Q9NQB0

Orphanet

24970

PDB

1JDH, 2GL7, 1JPW

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.97	27
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.656	14
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.612	7
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.61	6
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.597	6
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.543	5

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