Reactome | VE-cadherin [plasma membrane]

VE-cadherin [plasma membrane]

Stable Identifier

R-HSA-418992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CDH5, Cadherin-5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated vascular permeability (Homo sapiens)
        
        PAK1-3 phosphorylates VE-cadherin (Homo sapiens)
        
        VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
        
        VE-cadherin [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33151 CDH5

Gene Names

CDH5

Chain

signal peptide:1-25, propeptide:26-47, chain:48-784

Reference Genes

BioGPS Gene:1003 CDH5

COSMIC (genes):CDH5 CDH5

CTD Gene:1003 CDH5

dbSNP Gene:1003 CDH5

ENSEMBL:ENSG00000179776.19 CDH5

HGNC:1764 CDH5

KEGG Gene (Homo sapiens):1003 CDH5

Monarch:1003 CDH5

NCBI Gene:1003 CDH5

OMIM:601120 CDH5

UCSC:P33151 CDH5

Reference Transcript

RefSeq:NM_001795.4 CDH5

Other Identifiers

1003

11721651_at

11745128_a_at

16819794

204677_PM_at

204677_at

3664673

3664677

3664678

3664680

3664683

3664684

3664686

3664689

3664692

3664693

3664694

3664697

3664698

3664699

3664700

3664701

3664702

3664703

3664704

3664705

37196_at

7996264

A_14_P122438

A_23_P129496

A_33_P3728167

GE60059

GO:0000902

GO:0001932

GO:0001944

GO:0001955

GO:0003013

GO:0005102

GO:0005509

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005886

GO:0005911

GO:0005912

GO:0005923

GO:0006874

GO:0006954

GO:0007010

GO:0007043

GO:0007155

GO:0007156

GO:0007163

GO:0007179

GO:0008013

GO:0008285

GO:0009897

GO:0009986

GO:0010628

GO:0012501

GO:0016020

GO:0016339

GO:0016342

GO:0019903

GO:0023052

GO:0030054

GO:0030154

GO:0030335

GO:0030513

GO:0031115

GO:0031334

GO:0031965

GO:0034330

GO:0034332

GO:0035307

GO:0035633

GO:0036211

GO:0043114

GO:0043184

GO:0043226

GO:0043534

GO:0044325

GO:0044331

GO:0045296

GO:0045766

GO:0046872

GO:0048856

GO:0048870

GO:0050728

GO:0055065

GO:0065003

GO:0070051

GO:0070161

GO:0070700

GO:0070830

GO:0071944

GO:0098609

GO:0098742

GO:1902396

GO:1903142

GO:1990782

GO:2000114

GO:2000352

HMNXSV003051422

ILMN_1719236

PH_hs_0004397

TC16000514.hg

X79981_at

g4502726_3p_at

Participates

as a component of

VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)

as a member of

Classic Cadherin [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-S665-VE-cadherin [plasma membrane]

Inferred To

Cdh5 [plasma membrane] (Rattus norvegicus)

Ghost homologue of VE-cadherin [plasma membrane] (Caenorhabditis elegans)

Ghost homologue of VE-cadherin [plasma membrane] (Drosophila melanogaster)

VE-cadherin [plasma membrane] (Canis familiaris)

VE-cadherin [plasma membrane] (Danio rerio)

VE-cadherin [plasma membrane] (Gallus gallus)

VE-cadherin [plasma membrane] (Mus musculus)

cdh5 [plasma membrane] (Xenopus tropicalis)

CDH5 [plasma membrane] (Bos taurus)

CDH5 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001786.2

OpenTargets

ENSG00000179776

GeneCards

P33151

HPA

ENSG00000179776-CDH5

Ensembl

ENST00000649567, ENSP00000497290, ENSP00000479381, ENST00000341529, ENST00000614547, ENSG00000179776, ENSP00000344115

PRO

P33151

Pharos - Targets

P33151

HMDB Protein

HMDBP07521

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.857	7
UniProt:P35968 KDR	4	p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.564	2
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.544	2

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