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VE-cadherin [plasma membrane]
Stable Identifier
R-HSA-418992
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CDH5, Cadherin-5
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)
Cadherin trans-homodimer [cell junction] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)
Cadherin:Catenin complex [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
PAK1-3 phosphorylates VE-cadherin (Homo sapiens)
VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33151 CDH5
Gene Names
CDH5
Chain
signal peptide:1-25, propeptide:26-47, chain:48-784
Reference Genes
BioGPS Gene:1003 CDH5
COSMIC (genes):CDH5 CDH5
CTD Gene:1003 CDH5
dbSNP Gene:1003 CDH5
ENSEMBL:ENSG00000179776.19 CDH5
HGNC:1764 CDH5
KEGG Gene (Homo sapiens):1003 CDH5
Monarch:1003 CDH5
NCBI Gene:1003 CDH5
OMIM:601120 CDH5
UCSC:P33151 CDH5
Reference Transcript
RefSeq:NM_001795.4 CDH5
Other Identifiers
1003
11721651_at
11745128_a_at
16819794
204677_PM_at
204677_at
3664673
3664677
3664678
3664680
3664683
3664684
3664686
3664689
3664692
3664693
3664694
3664697
3664698
3664699
3664700
3664701
3664702
3664703
3664704
3664705
37196_at
7996264
A_14_P122438
A_23_P129496
A_33_P3728167
GE60059
GO:0000902
GO:0001932
GO:0001944
GO:0001955
GO:0003013
GO:0005102
GO:0005509
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005886
GO:0005911
GO:0005912
GO:0005923
GO:0006874
GO:0006954
GO:0007010
GO:0007043
GO:0007155
GO:0007156
GO:0007163
GO:0007179
GO:0008013
GO:0008285
GO:0009897
GO:0009986
GO:0010628
GO:0012501
GO:0016020
GO:0016339
GO:0016342
GO:0019903
GO:0023052
GO:0030054
GO:0030154
GO:0030335
GO:0030513
GO:0031115
GO:0031334
GO:0031965
GO:0034330
GO:0034332
GO:0035307
GO:0035633
GO:0036211
GO:0043114
GO:0043184
GO:0043226
GO:0043534
GO:0044325
GO:0044331
GO:0045296
GO:0045766
GO:0046872
GO:0048856
GO:0048870
GO:0050728
GO:0055065
GO:0065003
GO:0070051
GO:0070161
GO:0070700
GO:0070830
GO:0071944
GO:0098609
GO:0098742
GO:1902396
GO:1903142
GO:1990782
GO:2000114
GO:2000352
HMNXSV003051422
ILMN_1719236
PH_hs_0004397
TC16000514.hg
X79981_at
g4502726_3p_at
Participates
as a component of
VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
as a member of
Classic Cadherin [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-S665-VE-cadherin [plasma membrane]
Inferred To
Cdh5 [plasma membrane]
(Rattus norvegicus)
Ghost homologue of VE-cadherin [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of VE-cadherin [plasma membrane]
(Drosophila melanogaster)
VE-cadherin [plasma membrane]
(Canis familiaris)
VE-cadherin [plasma membrane]
(Danio rerio)
VE-cadherin [plasma membrane]
(Gallus gallus)
VE-cadherin [plasma membrane]
(Mus musculus)
cdh5 [plasma membrane]
(Xenopus tropicalis)
CDH5 [plasma membrane]
(Bos taurus)
CDH5 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001786.2
OpenTargets
ENSG00000179776
GeneCards
P33151
HPA
ENSG00000179776-CDH5
Ensembl
ENST00000649567
,
ENSP00000497290
,
ENSP00000479381
,
ENST00000341529
,
ENST00000614547
,
ENSG00000179776
,
ENSP00000344115
PRO
P33151
Pharos - Targets
P33151
HMDB Protein
HMDBP07521
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.857
7
UniProt:P35968 KDR
4
p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.564
2
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.544
2
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