Reactome | VE-cadherin [plasma membrane]

VE-cadherin [plasma membrane]

Stable Identifier

R-HSA-418992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CDH5, Cadherin-5

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated vascular permeability (Homo sapiens)
        
        PAK1-3 phosphorylates VE-cadherin (Homo sapiens)
        
        VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
        
        VE-cadherin [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33151 CDH5

Gene Names

CDH5

Chain

signal peptide:1-25, propeptide:26-47, chain:48-784

Reference Genes

BioGPS Gene:1003 CDH5

COSMIC (genes):CDH5 CDH5

CTD Gene:1003 CDH5

dbSNP Gene:1003 CDH5

ENSEMBL:ENSG00000179776 CDH5

HGNC:1764 CDH5

KEGG:hsa:1003 CDH5

Monarch:1003 CDH5

NCBI Gene:1003 CDH5

OMIM:601120 CDH5

UCSC:P33151 CDH5

Reference Transcript

RefSeq:NM_001795.4 CDH5

Other Identifiers

1003

11721651_at

11745128_a_at

16819794

204677_PM_at

204677_at

3664673

3664675

3664676

3664677

3664678

3664680

3664681

3664683

3664684

3664686

3664689

3664690

3664691

3664692

3664693

3664694

3664697

3664698

3664699

3664700

3664701

3664702

3664703

3664704

3664705

37196_at

7996264

A_14_P122438

A_14_P129330

A_23_P129496

A_33_P3728167

GE60059

GO:0000902

GO:0001886

GO:0001932

GO:0001955

GO:0003013

GO:0005102

GO:0005509

GO:0005515

GO:0005654

GO:0005737

GO:0005886

GO:0005911

GO:0005912

GO:0005923

GO:0006874

GO:0007043

GO:0007155

GO:0007156

GO:0007179

GO:0008013

GO:0008285

GO:0009897

GO:0009986

GO:0010628

GO:0016020

GO:0016339

GO:0016342

GO:0016477

GO:0019903

GO:0030054

GO:0030335

GO:0030513

GO:0031115

GO:0031334

GO:0031965

GO:0034330

GO:0034332

GO:0035307

GO:0035633

GO:0043114

GO:0043184

GO:0043534

GO:0044325

GO:0044331

GO:0045296

GO:0045766

GO:0046872

GO:0048870

GO:0050728

GO:0070051

GO:0070161

GO:0070700

GO:0070830

GO:0071944

GO:0098609

GO:1902396

GO:1903142

GO:1990782

GO:2000114

GO:2000352

HMNXSV003051422

ILMN_1719236

PH_hs_0004397

TC16000514.hg

X79981_at

g4502726_3p_at

Participates

as a component of

as a member of

Classic Cadherin [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-S665-VE-cadherin [plasma membrane]

Inferred To

Cdh5 [plasma membrane] (Rattus norvegicus)

Ghost homologue of VE-cadherin [plasma membrane] (Caenorhabditis elegans)

Ghost homologue of VE-cadherin [plasma membrane] (Xenopus tropicalis)

VE-cadherin [plasma membrane] (Danio rerio)

VE-cadherin [plasma membrane] (Gallus gallus)

VE-cadherin [plasma membrane] (Mus musculus)

CadN2 [plasma membrane] (Drosophila melanogaster)

CDH5 [plasma membrane] (Bos taurus)

CDH5 [plasma membrane] (Canis familiaris)

CDH5 [plasma membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSG00000179776, ENST00000649567, ENSP00000497290, ENST00000341529, ENSP00000344115

OpenTargets

ENSG00000179776

GeneCards

CDH5

HPA

ENSG00000179776-CDH5

PRO

P33151

Pharos - Targets

P33151

GlyGen

P33151

HMDB Protein

HMDBP07521

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.893	8
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.564	2
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.544	2
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.527	2
UniProt:Q9HCL2 GPAM	1	GPAM(1-828) [mitochondrial outer membrane] (R-HSA-61855)	0.527	2
UniProt:Q9P244 LRFN1	1	SALM2 [plasma membrane] (R-HSA-204734)	0.527	2
UniProt:P18850 ATF6	7	ATF6 [endoplasmic reticulum membrane] (R-HSA-381222) ATF6 [Golgi membrane] (R-HSA-381000) ATF6(1-419) [Golgi membrane] (R-HSA-420815) ATF6(1-380) [cytosol] (R-HSA-381075) ATF6(380-419) [Golgi membrane] (R-HSA-420817) ATF6(420-670) [Golgi membrane] (R-HSA-420814) ATF6(1-380) [nucleoplasm] (R-HSA-381211)	0.527	2
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.527	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.527	2
UniProt:P22059 OSBP	1	OSBP [cytosol] (R-HSA-429725)	0.527	2
UniProt:Q14118 DAG1	15	DAG1(654-895) [plasma membrane] (R-HSA-2328154) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region] (R-HSA-9913190) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen] (R-HSA-8932424) DAG1(654-895) [Golgi membrane] (R-HSA-9913184) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254)	0.527	2
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.527	2

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