Reactome | RUNX3 [nucleoplasm]

RUNX3 [nucleoplasm]

Stable Identifier

R-HSA-8865393

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Runt-related transcription factor 3, RUNX3_HUMAN, AML2, Acute myeloid leukemia 2 protein, CBF-alpha-3, CBFA3, AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, PEBP2A3, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13761 RUNX3

Gene Names

RUNX3, AML2, CBFA3, PEBP2A3

Chain

chain:1-415

Reference Genes

COSMIC (genes):RUNX3 RUNX3

dbSNP Gene:864 RUNX3

ENSEMBL:ENSG00000020633 RUNX3

Participates

as a component of

as an input of

as an output of

RUNX3 translocates to the nucleus (Homo sapiens)

Other forms of this molecule

PolyUb-RUNX3 [nucleoplasm]

p-Y-RUNX3 [cytosol]

PolyUb-K94,K148-RUNX3 [nucleoplasm]

PolyUb-K94,K148-RUNX3 [cytosol]

Ac-K94,K171-RUNX3 [nucleoplasm]

RUNX3 [cytosol]

Inferred To

Runx3 [nucleoplasm] (Mus musculus)

Ghost homologue of RUNX3 [nucleoplasm] (Xenopus tropicalis)

run [nucleoplasm] (Drosophila melanogaster)

Homologues of RUNX3 [nucleoplasm] (Drosophila melanogaster)

RUNX3 [nucleoplasm] (Bos taurus)

RUNX3 [nucleoplasm] (Caenorhabditis elegans)

RUNX3 [nucleoplasm] (Canis familiaris)

RUNX3 [nucleoplasm] (Danio rerio)

RUNX3 [nucleoplasm] (Gallus gallus)

RUNX3 [nucleoplasm] (Rattus norvegicus)

RUNX3 [nucleoplasm] (Sus scrofa)

RunxB [nucleoplasm] (Drosophila melanogaster)

lz [nucleoplasm] (Drosophila melanogaster)

RunxA [nucleoplasm] (Drosophila melanogaster)

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.656	12
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.656	14
UniProt:P25440 BRD2	1	BRD2 [nucleoplasm] (R-HSA-8951979)	0.599	8
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.593	3
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.558	9
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.558	7
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.499	5
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.499	3
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.462	8

© 2025 Reactome

Cite Us!