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HIC1 [nucleoplasm]
Stable Identifier
R-HSA-4090364
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Hypermethylated in cancer 1 protein, HIC1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)
HIC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14526 HIC1
Gene Names
HIC1, ZBTB29
Chain
chain:1-733
Reference Genes
BioGPS Gene:3090 HIC1
COSMIC (genes):HIC1 HIC1
CTD Gene:3090 HIC1
dbSNP Gene:3090 HIC1
ENSEMBL:ENSG00000177374 HIC1
HGNC:4909 HIC1
KEGG Gene (Homo sapiens):3090 HIC1
Monarch:3090 HIC1
NCBI Gene:3090 HIC1
OMIM:603825 HIC1
UCSC:Q14526 HIC1
Reference Transcript
RefSeq:NM_001098202.1 HIC1
RefSeq:NM_006497.3 HIC1
Other Identifiers
0003850086
11731301_a_at
11745613_a_at
11760064_x_at
16829618
208461_PM_at
208461_at
230218_PM_at
230218_at
235887_PM_at
235887_at
3090
34626_at
3706118
3706120
3706121
3706122
3706123
3706124
3706125
3706126
3706127
3706128
3706129
3706130
3706135
3706137
3706139
3706141
3706143
3706145
57653_at
68478_at
8003719
86316_at
A_23_P129856
A_23_P399169
GE618430
GE87137
GE907294
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006355
GO:0006357
GO:0006950
GO:0007165
GO:0007267
GO:0008150
GO:0008219
GO:0008630
GO:0009058
GO:0016055
GO:0019899
GO:0030178
GO:0034641
GO:0042826
GO:0043167
GO:0043226
GO:0043517
GO:0043565
GO:0046872
GO:1990837
HMNXSV003026884
Hs.196244.0.A1_3p_at
Hs.60137.0.A1_3p_at
ILMN_1738825
L41919_rna1_at
PH_hs_0031299
TC17000019.hg
g5729870_3p_at
Participates
as an input of
PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)
Other forms of this molecule
monoSUMO1-K333-HIC1 [nucleoplasm]
Inferred To
Homologues of HIC1 [nucleoplasm]
(Drosophila melanogaster)
Hic1 [nucleoplasm]
(Mus musculus)
LOC100912068 [nucleoplasm]
(Rattus norvegicus)
HIC1 [nucleoplasm]
(Bos taurus)
HIC1 [nucleoplasm]
(Canis familiaris)
HIC1 [nucleoplasm]
(Gallus gallus)
HIC1 [nucleoplasm]
(Sus scrofa)
Dmel\CG14711 [nucleoplasm]
(Drosophila melanogaster)
Cp190 [nucleoplasm]
(Drosophila melanogaster)
hic1 [nucleoplasm]
(Danio rerio)
hic1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006488.2
,
NP_001091672.1
OpenTargets
ENSG00000177374
HPA
ENSG00000177374-HIC1
GeneCards
Q14526
Ensembl
ENST00000619757
,
ENSP00000314080
,
ENSG00000177374
,
ENSP00000382742
,
ENST00000322941
,
ENSP00000477858
,
ENST00000399849
PRO
Q14526
Pharos - Targets
Q14526
Orphanet
16198
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O88712
3
Ctbp1 [nucleoplasm]
(R-MMU-3108200)
Ctbp1 [nucleoplasm]
(R-MMU-3108226)
Ctbp1 [nucleoplasm]
(R-MMU-212372)
0.796
10
UniProt:Q9NQB0 TCF7L2
4
TCF7L2 K485fs25* [nucleoplasm]
(R-HSA-5334040)
TCF7L2 R397W [nucleoplasm]
(R-HSA-5339696)
pT201,T212-TCF7L2 [nucleoplasm]
(R-HSA-4411392)
TCF7L2 [nucleoplasm]
(R-HSA-201923)
0.61
6
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
0.573
2
UniProt:O14497 ARID1A
1
ARID1A [nucleoplasm]
(R-HSA-389259)
0.508
2
UniProt:P56546 Ctbp2
0.508
2
UniProt:P56545 CTBP2
1
CTBP2 [nucleoplasm]
(R-HSA-5333990)
0.508
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.463
2
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