Reactome | HIC1 [nucleoplasm]

HIC1 [nucleoplasm]

Stable Identifier

R-HSA-4090364

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Hypermethylated in cancer 1 protein, HIC1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14526 HIC1

Gene Names

HIC1, ZBTB29

Chain

chain:1-733

Reference Genes

BioGPS Gene:3090 HIC1

COSMIC (genes):HIC1 HIC1

CTD Gene:3090 HIC1

dbSNP Gene:3090 HIC1

ENSEMBL:ENSG00000177374 HIC1

HGNC:4909 HIC1

KEGG Gene (Homo sapiens):3090 HIC1

Monarch:3090 HIC1

NCBI Gene:3090 HIC1

OMIM:603825 HIC1

UCSC:Q14526 HIC1

Reference Transcript

Other Identifiers

0003850086

11731301_a_at

11745613_a_at

11760064_x_at

16829618

208461_at

230218_at

235887_at

3090

34626_at

3706118

3706120

3706121

3706122

3706123

3706124

3706125

3706126

3706127

3706128

3706129

3706130

3706135

3706137

3706139

3706141

3706143

3706145

57653_at

68478_at

8003719

86316_at

A_23_P129856

A_23_P399169

GE618430

GE87137

GE907294

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001227

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006355

GO:0006357

GO:0006950

GO:0007165

GO:0007267

GO:0007275

GO:0008150

GO:0008219

GO:0008630

GO:0009058

GO:0016055

GO:0019899

GO:0030178

GO:0034641

GO:0042826

GO:0043167

GO:0043226

GO:0043517

GO:0043565

GO:0046872

GO:0048856

GO:1990837

HMNXSV003026884

Hs.196244.0.A1_3p_at

Hs.60137.0.A1_3p_at

ILMN_1738825

L41919_rna1_at

PH_hs_0031299

TC17000019.hg

g5729870_3p_at

Participates

as an input of

PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)

Other forms of this molecule

SUMO1-K333-HIC1 [nucleoplasm]

Inferred To

Hic1 [nucleoplasm] (Mus musculus)

LOC100912068 [nucleoplasm] (Rattus norvegicus)

HIC1 [nucleoplasm] (Canis familiaris)

HIC1 [nucleoplasm] (Gallus gallus)

HIC1 [nucleoplasm] (Sus scrofa)

Cp190 [nucleoplasm] (Drosophila melanogaster)

hic1 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001091672.1, NP_006488.2

OpenTargets

ENSG00000177374

GeneCards

Q14526

HPA

ENSG00000177374-HIC1

Ensembl

ENSP00000382742, ENSG00000177374, ENST00000399849, ENST00000322941, ENST00000619757, ENSP00000477858, ENSP00000314080

PRO

Q14526

Orphanet

16198

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88712	3	Ctbp1 [nucleoplasm] (R-MMU-3108226) Ctbp1 [nucleoplasm] (R-MMU-3108200) Ctbp1 [nucleoplasm] (R-MMU-212372)	0.796	10
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) TCF7L2 K485fs25* [nucleoplasm] (R-HSA-5334040) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.61	6
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) SUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) SUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226)	0.573	2
UniProt:O14497 ARID1A	1	ARID1A [nucleoplasm] (R-HSA-389259)	0.508	2
UniProt:P56546 Ctbp2	1	Ctbp2 [nucleoplasm] (R-MMU-5333990)	0.508	2
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.508	2
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.463	2

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