Reactome | DOT1L [nucleoplasm]

DOT1L [nucleoplasm]

Stable Identifier

R-HSA-3239030

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase, H3 lysine-79 specific, DOT1L_HUMAN, KMT4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TEK3 DOT1L

Gene Names

DOT1L, KIAA1814, KMT4

Chain

chain:1-1537

Reference Genes

BioGPS Gene:84444 DOT1L

COSMIC (genes):DOT1L DOT1L

CTD Gene:84444 DOT1L

dbSNP Gene:84444 DOT1L

ENSEMBL:ENSG00000104885 DOT1L

ENSEMBL_homo_sapiens_GENE:ENSG00000104885.19 DOT1L

HGNC:24948 DOT1L

KEGG Gene (Homo sapiens):84444 DOT1L

Monarch:84444 DOT1L

NCBI Gene:84444 DOT1L

OMIM:607375 DOT1L

UCSC:Q8TEK3 DOT1L

Reference Transcript

RefSeq:NM_032482.2 DOT1L

Other Identifiers

11721397_at

11721398_a_at

16856699

214865_PM_at

214865_at

226201_PM_at

226201_at

231297_PM_at

231297_at

3816265

3816266

3816267

3816268

3816269

3816274

3816279

3816280

3816281

3816284

3816285

3816286

3816287

3816288

3816289

3816290

3816291

3816293

3816294

3816295

3816296

3816297

3816298

3816299

3816300

3816302

3816306

3816307

3816308

3816310

3816312

3816314

3816316

3816317

3816327

3816328

3816329

3816330

40525_at

43492_at

47137_at

8024391

84444

A_23_P101737

A_23_P408768

A_24_P936875

GE53989

GO:0000077

GO:0003676

GO:0003677

GO:0003713

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006281

GO:0006325

GO:0006351

GO:0006355

GO:0008168

GO:0008284

GO:0010467

GO:0016740

GO:0023052

GO:0031151

GO:0031507

GO:0032200

GO:0032259

GO:0032991

GO:0034729

GO:0036211

GO:0042054

GO:0043226

GO:0043231

GO:0045893

GO:0045944

GO:0046425

GO:0051726

GO:0061629

GO:0140096

GO:0140110

GO:0140938

GO:0140956

GO:2000677

HMNXSV003056003

Hs.156015.0.A1_3p_at

Hs.173739.1.S1_3p_at

Hs.173739.2.S1_3p_at

ILMN_1693559

PH_hs_0023520

RNA94992|RNS_74_197

TC19000049.hg

TC19001937.hg

Inferred To

DOT1L [nucleoplasm] (Bos taurus)

DOT1L [nucleoplasm] (Caenorhabditis elegans)

DOT1L [nucleoplasm] (Canis familiaris)

DOT1L [nucleoplasm] (Dictyostelium discoideum)

DOT1L [nucleoplasm] (Mus musculus)

DOT1L [nucleoplasm] (Rattus norvegicus)

DOT1L [nucleoplasm] (Saccharomyces cerevisiae)

DOT1L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_115871.1

Guide to Pharmacology - Targets

2650

OpenTargets

ENSG00000104885

IntEnz

2.1.1.360

HPA

ENSG00000104885-DOT1L

GeneCards

Q8TEK3

Ensembl

ENSG00000104885, ENST00000398665, ENSP00000381657

ZINC target

Q8TEK3

PRO

Q8TEK3

Pharos - Targets

Q8TEK3

HMDB Protein

HMDBP00402

PDB

7S7E, 1NW3, 3UWP, 2MV7, 7S7F, 7BWD, 3SR4, 4ER3, 4WVL, 4EK9, 6JM9, 5MW3, 5DSX, 5DT2, 4ER5, 5MVS, 5DTQ, 3SX0, 4EQZ, 6NJ9, 6TE6, 3QOX, 4ER0, 6NN6, 3QOW, 5DTR, 6O96, 4EKG, 5JUW, 5DRT, 6NOG, 6JN2, 5DRY, 4HRA, 5DTM, 4EKI, 6NQA, 4ER7, 7XCR, 7XCT, 4ER6, 6TEL, 6J99, 7EDP, 6IN3, 6TEN, 6JMA, 5MW4

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.821	7
UniProt:P55197 AF10			0.773	7
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.677	8
UniProt:P55198 AF17			0.643	4
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.564	3

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