Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
pT201,T212-TCF7L2 [nucleoplasm]
Stable Identifier
R-HSA-4411392
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TCF7L2 (TCF4), hTCF-4_1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
NLK phosphorylates TCF/LEF (Homo sapiens)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
p-TCF/LEF [nucleoplasm] (Homo sapiens)
pT201,T212-TCF7L2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQB0 TCF7L2
Gene Names
TCF7L2, TCF4
Chain
chain:1-619
Reference Genes
BioGPS Gene:6934 TCF7L2
COSMIC (genes):TCF7L2 TCF7L2
CTD Gene:6934 TCF7L2
dbSNP Gene:6934 TCF7L2
ENSEMBL:ENSG00000148737.17 TCF7L2
ENSEMBL:ENSG00000148737.18 TCF7L2
HGNC:11641 TCF7L2
KEGG Gene (Homo sapiens):6934 TCF7L2
Monarch:6934 TCF7L2
NCBI Gene:6934 TCF7L2
OMIM:602228 TCF7L2
UCSC:Q9NQB0 TCF7L2
Reference Transcript
RefSeq:NM_001146274.1 TCF7L2
RefSeq:XM_017016592.1 TCF7L2
RefSeq:NM_001198528.1 TCF7L2
RefSeq:XM_017016593.1 TCF7L2
RefSeq:XM_005270103.1 TCF7L2
RefSeq:NM_001198526.1 TCF7L2
RefSeq:XM_005270096.2 TCF7L2
RefSeq:NM_001146286.1 TCF7L2
RefSeq:XM_005270089.1 TCF7L2
RefSeq:NM_001146284.1 TCF7L2
RefSeq:XM_005270084.1 TCF7L2
RefSeq:NM_001146283.1 TCF7L2
RefSeq:NM_001198531.1 TCF7L2
Other Identifiers
11746313_a_at
11746314_s_at
11746315_x_at
11746404_a_at
11747829_x_at
11751102_x_at
11755181_a_at
16709333
212759_PM_s_at
212759_s_at
212761_PM_at
212761_at
212762_PM_s_at
212762_s_at
216035_PM_x_at
216035_x_at
216037_PM_x_at
216037_x_at
216511_PM_s_at
216511_s_at
32025_at
3264622
3264623
3264624
3264626
3264627
3264633
3264652
3264659
3264685
3264689
3264692
3264696
3264697
3264698
3264699
3264708
3264710
3264712
3264714
3264722
3264723
3264724
3264725
3264726
48528_at
6934
7930537
A_14_P125103
A_14_P133398
A_23_P127013
A_23_P389588
A_24_P921823
A_33_P3377304
GE83165
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001568
GO:0003676
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0008013
GO:0009749
GO:0010909
GO:0012501
GO:0016055
GO:0016605
GO:0016922
GO:0019901
GO:0023052
GO:0030154
GO:0031016
GO:0032024
GO:0032092
GO:0032350
GO:0032993
GO:0042593
GO:0043226
GO:0043433
GO:0043565
GO:0043570
GO:0044334
GO:0045295
GO:0045444
GO:0045892
GO:0045944
GO:0048625
GO:0048660
GO:0048856
GO:0050679
GO:0051897
GO:0060070
GO:0060090
GO:0061629
GO:0070016
GO:0070369
GO:0071664
GO:0090090
GO:0140110
GO:1900182
GO:1901135
GO:1990907
GO:2000675
GO:2001237
HMNXSV003004532
HMNXSV003007299
HMNXSV003057192
Hs.173638.0.S1_3p_s_at
Hs.173638.0.S2_3p_s_at
Hs.173638.0.S3_3p_a_at
Hs.173638.0.S3_3p_at
Hs.173638.1.S1_3p_x_at
Hs.173638.2.S1_3p_a_at
Hs.173638.2.S1_3p_x_at
Hs.283857.0.S1_3p_s_at
ILMN_1672486
TC10000820.hg
TC10002300.hg
Y11306_rna1_at
Participates
as a member of
p-TCF/LEF [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TCF7L2 K485fs*25 [nucleoplasm]
TCF7L2 R397W [nucleoplasm]
TCF7L2 [nucleoplasm]
Inferred To
phospho-Tcf7l2 [nucleoplasm]
(Mus musculus)
phospho-Tcf7l2 [nucleoplasm]
(Rattus norvegicus)
phospho-pop-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-pT201,T212-TCF7L2 [nucleoplasm]
(Canis familiaris)
phospho-pT201,T212-TCF7L2 [nucleoplasm]
(Danio rerio)
phospho-pT201,T212-TCF7L2 [nucleoplasm]
(Gallus gallus)
phospho-pan [nucleoplasm]
(Drosophila melanogaster)
phospho-TCF7L2 [nucleoplasm]
(Bos taurus)
phospho-TCF7L2 [nucleoplasm]
(Sus scrofa)
phospho-tcf7l2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 201
Coordinate
201
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 212
Coordinate
212
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_005270153.1
,
NP_001185455.1
,
XP_016872081.1
,
NP_001139756.1
,
XP_005270141.1
,
NP_001185460.1
,
XP_016872082.1
,
XP_005270160.1
,
NP_001185457.1
,
NP_001139758.1
,
NP_001139755.1
,
XP_005270146.1
,
NP_001139746.1
OpenTargets
ENSG00000148737
GeneCards
Q9NQB0
HPA
ENSG00000148737-TCF7L2
Ensembl
ENSG00000148737
,
ENSP00000348274
,
ENST00000627217
,
ENST00000538897
,
ENST00000369397
,
ENSP00000486891
,
ENST00000355717
,
ENSP00000358404
,
ENST00000355995
,
ENST00000352065
,
ENSP00000446172
,
ENSP00000344823
,
ENSP00000347949
PRO
Q9NQB0
Pharos - Targets
Q9NQB0
Orphanet
24970
PDB
1JPW
,
2GL7
,
1JDH
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.97
27
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.656
14
UniProt:Q08050 FOXM1
3
p-T611,S730,S739-FOXM1 [nucleoplasm]
(R-HSA-4088133)
p-T611-FOXM1 [nucleoplasm]
(R-HSA-4088026)
FOXM1 [nucleoplasm]
(R-HSA-4088019)
0.612
7
UniProt:Q14526 HIC1
2
monoSUMO1-K333-HIC1 [nucleoplasm]
(R-HSA-4090368)
HIC1 [nucleoplasm]
(R-HSA-4090364)
0.61
6
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.597
6
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.59
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.543
5
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text