Reactome | pT201,T212-TCF7L2 [nucleoplasm]

pT201,T212-TCF7L2 [nucleoplasm]

Stable Identifier

R-HSA-4411392

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TCF7L2 (TCF4), hTCF-4_1

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External Reference Information

External Reference

UniProt:Q9NQB0 TCF7L2

Gene Names

TCF7L2, TCF4

Chain

chain:1-619

Reference Genes

BioGPS Gene:6934 TCF7L2

COSMIC (genes):TCF4 TCF7L2

COSMIC (genes):TCF7L2 TCF7L2

CTD Gene:6934 TCF7L2

dbSNP Gene:6934 TCF7L2

ENSEMBL:ENSG00000148737 TCF7L2

HGNC:11641 TCF7L2

KEGG:hsa:6934 TCF7L2

Monarch:6934 TCF7L2

NCBI Gene:6934 TCF7L2

OMIM:602228 TCF7L2

UCSC:Q9NQB0 TCF7L2

Reference Transcript

Participates

as a member of

p-TCF/LEF [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TCF7L2 [nucleoplasm]

TCF7L2 R397W [nucleoplasm]

TCF7L2 K485fs*25 [nucleoplasm]

Inferred To

phospho-Tcf7l2 [nucleoplasm] (Mus musculus)

phospho-Tcf7l2 [nucleoplasm] (Rattus norvegicus)

phospho-pop-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-pT201,T212-TCF7L2 [nucleoplasm] (Gallus gallus)

phospho-pan [nucleoplasm] (Drosophila melanogaster)

phospho-TCF7L2 [nucleoplasm] (Bos taurus)

phospho-TCF7L2 [nucleoplasm] (Canis familiaris)

phospho-TCF7L2 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 201

Coordinate

201

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 212

Coordinate

212

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001139758.1, NP_001139755.1, NP_001185457.1, NP_001185455.1, NP_001185460.1, XP_005270146.1, XP_016872081.1, NP_001139746.1, NP_001139756.1, XP_005270153.1, XP_016872082.1, XP_005270141.1, XP_005270160.1

OpenTargets

ENSG00000148737

ENSEMBL

ENST00000369397, ENSP00000446172, ENST00000355717, ENST00000538897, ENSP00000348274, ENSP00000358404, ENSP00000486891, ENST00000627217, ENST00000352065, ENSP00000344823, ENSG00000148737, ENSP00000347949, ENST00000355995

HPA

ENSG00000148737-TCF7L2

GeneCards

TCF7L2

PRO

Q9NQB0

Pharos - Targets

Q9NQB0

Orphanet

TCF7L2

PDB

1JDH, 1JPW, 2GL7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.97	27
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.656	14
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.612	7
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.61	6
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.597	6
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.543	5

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