Reactome | PolyUb-PKM-1 [cytosol]

PolyUb-PKM-1 [cytosol]

Stable Identifier

R-HSA-9861692

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKM isozyme M2, pyruvate kinase, M2 isozyme

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14618-1 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Participates

as an output of

CTLH E3 ligase ubiquitinates PKM-1 (Homo sapiens)

This entity regulates

Negatively

Pyruvate kinase dephosphorylates PEP to PYR (Homo sapiens)

Other forms of this molecule

PKM-1 [cytosol]

Inferred To

pyk1 [cytosol] (Schizosaccharomyces pombe)

Pkml1 [cytosol] (Rattus norvegicus)

Pykl5 [cytosol] (Drosophila melanogaster)

PKLR [cytosol] (Gallus gallus)

pyk-2 [cytosol] (Caenorhabditis elegans)

pkma [cytosol] (Danio rerio)

Pykl1 [cytosol] (Drosophila melanogaster)

PKM2 [cytosol] (Bos taurus)

Pykl2 [cytosol] (Drosophila melanogaster)

Pykl3 [cytosol] (Drosophila melanogaster)

pkm [cytosol] (Xenopus tropicalis)

Pkm [cytosol] (Mus musculus)

PYK2 [cytosol] (Saccharomyces cerevisiae)

Pyk [cytosol] (Drosophila melanogaster)

pyk [cytosol] (Dictyostelium discoideum)

PKM [cytosol] (Sus scrofa)

Pykl4 [cytosol] (Drosophila melanogaster)

CDC19 [cytosol] (Saccharomyces cerevisiae)

PolyUb-PKM-1 [cytosol] (Plasmodium falciparum)

pyk-1 [cytosol] (Caenorhabditis elegans)

Homologues of PolyUb-PKM-1 [cytosol] (Caenorhabditis elegans)

Homologues of PolyUb-PKM-1 [cytosol] (Drosophila melanogaster)

Homologues of PolyUb-PKM-1 [cytosol] (Plasmodium falciparum)

Homologues of PolyUb-PKM-1 [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_872271.1, NP_001193726.1, NP_872270.1, NP_001193725.1, NP_001303247.1, NP_001193728.1, XP_005254502.1, XP_047288622.1, NP_001193727.1, XP_016877802.1, NP_002645.3

Guide to Pharmacology - Targets

3006

OpenTargets

ENSG00000067225

ENSEMBL

ENSG00000067225, ENSP00000334983, ENSP00000456970, ENST00000568459, ENST00000319622, ENST00000335181, ENSP00000320171

ZINC - Substances

KPYM_HUMAN

ZINC - Biogenic

KPYM_HUMAN

ZINC target

P14618

PRO

P14618

GlyGen

P14618

PDB

7L21, 3BJF, 3GR4, 5X0I, 6NUB, 1ZJH, 6TTF, 3G2G, 6GG4, 8G2E, 4QG6, 8HMU, 4FXF, 6TTI, 6NU1, 6GG3, 4G1N, 4B2D, 6V75, 4WJ8, 6WP6, 3SRH, 3SRF, 4QG9, 8HMR, 8X4R, 4JPG, 6WP4, 4RPP, 3GQY, 3U2Z, 3BJT, 8HGF, 5X1V, 5X1W, 6NU5, 6GG5, 6B6U, 4QGC, 6TTH, 6TTQ, 3SRD, 4YJ5, 6V76, 6JFB, 3ME3, 1T5A, 6GG6, 4FXJ, 6WP5, 4QG8, 8HMS, 8HMQ, 3H6O, 6V74, 6WP3

ZINC - Metabolites

KPYM_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000067225-PKM

GeneCards

PKM

Pharos - Targets

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

HMDB Protein

HMDBP00763

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	9
UniProt:P03129 VE7			0.646	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	20
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q96IK1-2 Q96IK12			0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9WMX2 POLG			0.556	4
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P04020 VE7			0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.524	4
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.524	3
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.519	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3

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