Reactome | PolyUb-PKM-1 [cytosol]

PolyUb-PKM-1 [cytosol]

Stable Identifier

R-HSA-9861692

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKM isozyme M2, pyruvate kinase, M2 isozyme

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14618-1 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Other Identifiers

11722787_a_at

11752165_s_at

11752166_x_at

11752342_x_at

11752458_a_at

11756971_x_at

16811372

201251_PM_at

201251_at

209446_PM_s_at

209446_s_at

213700_PM_s_at

213700_s_at

2893336

2893342

3103883

3103886

3103891

3103895

32378_at

3631961

3631963

3631965

3631966

3631967

3631968

3631969

3631970

3631971

3631972

3631973

3631974

3631975

3631976

3631977

3631978

3631979

3631980

3631981

3631982

3631983

3631984

3631985

3631986

3631987

3631988

3631989

3631990

3631992

3631993

3631994

3631995

3631996

3631997

3631998

3631999

3632000

3632001

3632002

3632003

3632004

3632005

3632006

3632007

3632009

3632010

3632011

3632015

3632016

3632017

3632018

3632019

3632027

3632029

3632030

3632031

3632032

3632033

3632034

3632035

3632036

3979839

40925_at

5315

7990151

85992_at

A_23_P399501

A_24_P482017

A_32_P147241

GE81173

GO:0000287

GO:0003713

GO:0003723

GO:0003729

GO:0003824

GO:0004713

GO:0004743

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005791

GO:0005829

GO:0005929

GO:0005975

GO:0006091

GO:0006096

GO:0006325

GO:0006338

GO:0006355

GO:0006417

GO:0012501

GO:0016301

GO:0016740

GO:0023026

GO:0030312

GO:0030955

GO:0031012

GO:0031982

GO:0032869

GO:0034774

GO:0035402

GO:0042803

GO:0043226

GO:0045296

GO:0045944

GO:0046872

GO:0055086

GO:0060090

GO:0061621

GO:0062023

GO:0070062

GO:0140096

GO:0140110

GO:1901135

GO:1903561

GO:1903672

GO:1904813

GO:2000767

HMNXSV003020043

Hs.8173.2.A1_3p_a_at

ILMN_1672650

ILMN_1775327

ILMN_2366634

PH_hs_0029415

TC15002609.hg

TC15002610.hg

TC15002776.hg

X56494_at

g12804636_3p_x_at

g4505838_3p_at

g4505838_3p_x_at

Participates

as an output of

CTLH E3 ligase ubiquitinates PKM-1 (Homo sapiens)

This entity regulates

Negatively

PKM dephosphorylates PEP to PYR (Homo sapiens)

Other forms of this molecule

PKM-1 [cytosol]

Inferred To

Pkml1 [cytosol] (Rattus norvegicus)

pyk-2 [cytosol] (Caenorhabditis elegans)

Dmel\CG12229 [cytosol] (Drosophila melanogaster)

pkma [cytosol] (Danio rerio)

Dmel\CG7069 [cytosol] (Drosophila melanogaster)

Dmel\CG11249 [cytosol] (Drosophila melanogaster)

Dmel\CG7362 [cytosol] (Drosophila melanogaster)

pkm [cytosol] (Xenopus tropicalis)

Dmel\CG2964 [cytosol] (Drosophila melanogaster)

PKM [cytosol] (Bos taurus)

PKM [cytosol] (Sus scrofa)

pklr [cytosol] (Danio rerio)

PolyUb-PKM-1 [cytosol] (Dictyostelium discoideum)

PolyUb-PKM-1 [cytosol] (Drosophila melanogaster)

PolyUb-PKM-1 [cytosol] (Gallus gallus)

PolyUb-PKM-1 [cytosol] (Mus musculus)

PolyUb-PKM-1 [cytosol] (Plasmodium falciparum)

PolyUb-PKM-1 [cytosol] (Saccharomyces cerevisiae)

PolyUb-PKM-1 [cytosol] (Schizosaccharomyces pombe)

pyk-1 [cytosol] (Caenorhabditis elegans)

Homologues of PolyUb-PKM-1 [cytosol] (Caenorhabditis elegans)

Homologues of PolyUb-PKM-1 [cytosol] (Danio rerio)

Homologues of PolyUb-PKM-1 [cytosol] (Drosophila melanogaster)

Homologues of PolyUb-PKM-1 [cytosol] (Plasmodium falciparum)

Homologues of PolyUb-PKM-1 [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001303247.1, NP_001193726.1, XP_005254502.1, NP_001193725.1, NP_002645.3, NP_872270.1, NP_872271.1, NP_001193728.1, NP_001193727.1, XP_016877802.1

Guide to Pharmacology - Targets

3006

OpenTargets

ENSG00000067225

ENSEMBL

ENSP00000320171, ENSP00000456970, ENST00000568459, ENST00000335181, ENST00000319622, ENSP00000334983

ZINC - Substances

KPYM_HUMAN

ZINC - Biogenic

KPYM_HUMAN

ZINC target

P14618

PRO

P14618

GlyGen

P14618

PDB

7L21, 1ZJH, 6TTF, 3G2G, 6TTQ, 6TTH, 8HMU, 3SRD, 6B6U, 6GG5, 1T5A, 6WP4, 8HMS, 8HMQ, 4FXF, 4QG8, 6GG6, 6WP6, 4G1N, 6V76, 4WJ8, 4JPG, 8HGF, 5X0I, 3U2Z, 3GR4, 3BJT, 6NU5, 5X1W, 5X1V, 6GG3, 6NU1, 6TTI, 4QG6, 4QGC, 6GG4, 8G2E, 3ME3, 4FXJ, 6WP3, 3SRH, 8HMR, 6V74, 3SRF, 4QG9, 3H6O, 4YJ5, 6JFB, 6WP5, 4B2D, 6V75, 4RPP, 3GQY, 6NUB, 3BJF

ZINC - Metabolites

KPYM_HUMAN

IntEnz

2.7.10.2

HPA

ENSG00000067225-PKM

Pharos - Targets

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

HMDB Protein

HMDBP00763

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	9
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.524	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4

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