Reactome | PolyUb-AR [nucleoplasm]

PolyUb-AR [nucleoplasm]

Stable Identifier

R-HSA-6782984

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Androgen receptor, ANDR_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10275 AR

Gene Names

AR, DHTR, NR3C4

Chain

chain:1-920

Reference Genes

BioGPS Gene:367 AR

COSMIC (genes):AR AR

CTD Gene:367 AR

dbSNP Gene:367 AR

ENSEMBL:ENSG00000169083 AR

ENSEMBL_homo_sapiens_GENE:ENSG00000169083.18 AR

HGNC:644 AR

KEGG Gene (Homo sapiens):367 AR

Monarch:367 AR

NCBI Gene:367 AR

OMIM:313700 AR

UCSC:P10275 AR

Reference Transcript

Other Identifiers

11737903_a_at

11742471_a_at

11752265_a_at

11762394_a_at

1577_at

1578_g_at

17104313

211110_PM_s_at

211110_s_at

226192_PM_at

226192_at

226197_PM_at

226197_at

367

3979915

3979916

3979917

3979918

3979919

3979920

3979921

3979922

3979923

3979924

3979925

3979926

3979927

3979928

3979929

3979930

3979931

3979932

3979933

3979934

3979955

3979956

3979964

3979968

3979970

3979971

3979972

3979973

3979975

3979977

3979978

3979979

3979980

3979981

3979982

3979983

3979988

3979989

3979990

3979992

43435_at

43436_g_at

52851_at

52853_g_at

8167998

A_14_P120121

A_14_P201842

A_23_P113111

GE58203

GE87814

GO:0000122

GO:0000165

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001091

GO:0001223

GO:0001228

GO:0001701

GO:0003013

GO:0003073

GO:0003382

GO:0003677

GO:0003682

GO:0003700

GO:0004879

GO:0004930

GO:0005102

GO:0005496

GO:0005497

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007165

GO:0007186

GO:0007267

GO:0007283

GO:0007338

GO:0008013

GO:0008270

GO:0008284

GO:0008285

GO:0008289

GO:0008584

GO:0009566

GO:0010468

GO:0010628

GO:0012501

GO:0016607

GO:0019102

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030518

GO:0030520

GO:0030521

GO:0030522

GO:0032991

GO:0033148

GO:0033327

GO:0034056

GO:0035264

GO:0042327

GO:0043226

GO:0043410

GO:0043565

GO:0043568

GO:0045597

GO:0045720

GO:0045726

GO:0045893

GO:0045944

GO:0045945

GO:0046872

GO:0048009

GO:0048608

GO:0048638

GO:0048645

GO:0048808

GO:0048856

GO:0050673

GO:0050680

GO:0051092

GO:0051117

GO:0060089

GO:0060090

GO:0060520

GO:0060571

GO:0060599

GO:0060685

GO:0060736

GO:0060740

GO:0060742

GO:0060748

GO:0060749

GO:0060769

GO:0061024

GO:0061458

GO:0061629

GO:0070974

GO:0071383

GO:0071391

GO:0071394

GO:0072520

GO:0072659

GO:0140110

GO:1902895

GO:1903076

GO:1990837

GO:2001237

HMNXSV003053460

Hs.76704.0.A1_3p_at

Hs.76704.0.A2_3p_at

ILMN_1659572

ILMN_1767351

M23263_at

M35851_s_at

PH_hs_0005583

TC0X000358.hg

g178655_3p_at

g5639998_3p_s_at

Participates

as a component of

USP12:WDR48:WDR20,USP26:PolyUb-AR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K386,520-AR [nucleoplasm]

AR [nucleoplasm]

AR [cytosol]

Inferred To

Homologues of PolyUb-AR [nucleoplasm] (Drosophila melanogaster)

knrl [nucleoplasm] (Drosophila melanogaster)

AR [nucleoplasm] (Bos taurus)

AR [nucleoplasm] (Canis familiaris)

AR [nucleoplasm] (Gallus gallus)

AR [nucleoplasm] (Sus scrofa)

ar [nucleoplasm] (Danio rerio)

ar [nucleoplasm] (Xenopus tropicalis)

ERR [nucleoplasm] (Drosophila melanogaster)

PolyUb-AR [nucleoplasm] (Mus musculus)

PolyUb-AR [nucleoplasm] (Rattus norvegicus)

Ghost homologue of PolyUb-AR [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of PolyUb-AR [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of PolyUb-AR [nucleoplasm] (Schizosaccharomyces pombe)

kni [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_000035.2, NP_001334992.1, NP_001011645.1, NP_001334990.1, NP_001334993.1

ZINC - World Drugs

ANDR_HUMAN

Guide to Pharmacology - Targets

628

OpenTargets

ENSG00000169083

ZINC - FDA approved

ANDR_HUMAN

ZINC - Substances

ANDR_HUMAN

ZINC target

P10275

ZINC - Biogenic

ANDR_HUMAN

PRO

P10275

PDB

2PIR, 2HVC, 4OJB, 8FH1, 2AX7, 8FGY, 8FGZ, 3B67, 4OKW, 2Q7K, 3L3Z, 4OKX, 8FH2, 2YLO, 3B66, 4OH6, 4OFR, 2PIW, 1Z95, 3L3X, 1XOW, 2PIP, 2Z4J, 4OIL, 2PIV, 2YHD, 2AMB, 4OLM, 5VO4, 4OIU, 5CJ6, 5T8E, 2PIO, 3V4A, 1XQ3, 8RM7, 8E1A, 7ZU1, 5T8J, 4OEZ, 3RLL, 2YLQ, 1T63, 4OJ9, 2OZ7, 2AMA, 8FH0, 2PIT, 4OGH, 4OEA, 4OKT, 4K7A, 2YLP, 3RLJ, 5V8Q, 1GS4, 2AM9, 2PKL, 2AX6, 2PIX, 5JJM, 4OED, 2AXA, 3B65, 2Q7J, 3ZQT, 4OH5, 2PIQ, 4OK1, 4HLW, 2PNU, 4QL8, 3V49, 2Q7I, 3B5R, 1E3G, 1XJ7, 4OFU, 2PIU, 4OHA, 1T65, 4OEY, 4OKB, 2AX9, 2AX8, 7ZTX, 8RM6, 3BTR, 2AO6, 1T5Z, 3B68, 2Q7L, 7ZU2, 7ZTZ

ZINC - Investigational

ANDR_HUMAN

ZINC - Metabolites

ANDR_HUMAN

HPA

ENSG00000169083-AR

GeneCards

P10275

Ensembl

ENSP00000484033, ENSP00000421155, ENST00000504326, ENST00000612452, ENSG00000169083, ENSP00000363822, ENST00000374690

Pharos - Targets

P10275

ZINC - Predictions - Purchasable

ANDR_HUMAN

Orphanet

16667

HMDB Protein

HMDBP01624

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-1776214 KLK3			0.922	18
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.891	15
IntAct:EBI-2602074 TMPS2			0.886	13
UniProt:P55317 FOXA1	1	FOXA1 [nucleoplasm] (R-HSA-453074)	0.713	4
UniProt:Q15596 NCOA2	3	monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305) NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) NCOA2 [nucleoplasm] (R-HSA-376398)	0.692	4
UniProt:P11308 ERG			0.688	4
UniProt:O60885-1 BRD4			0.682	6
IntAct:EBI-2677345 NDRG1			0.669	4
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.667	4
UniProt:Q15652 JMJD1C	1	JMJD1C [nucleoplasm] (R-HSA-997258)	0.637	4
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.628	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.625	5
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.618	3
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.604	3
UniProt:P07288 KLK3	1	KLK3 [extracellular region] (R-HSA-381416)	0.604	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.604	3
UniProt:Q15797 SMAD1	4	Ub-SMAD1 [cytosol] (R-HSA-6782768) SMAD1 [cytosol] (R-HSA-201468) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483)	0.602	6
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.602	5
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.602	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.602	7
UniProt:O95251 KAT7	1	KAT7 [nucleoplasm] (R-HSA-3321823)	0.593	5
UniProt:Q9R1E0 Foxo1	6	phospho-Foxo1 [nucleoplasm] (R-MMU-5692651) Ac-K242,K245,K262-Foxo1 [nucleoplasm] (R-MMU-9626941) phospho-Foxo1 [cytosol] (R-MMU-211158) phospho-Foxo1 [nucleoplasm] (R-MMU-199306) Foxo1 [nucleoplasm] (R-MMU-187293) Foxo1 [nucleoplasm] (R-MMU-199300)	0.592	4
UniProt:Q9Y252 RNF6	1	RNF6 [cytosol] (R-HSA-975997)	0.584	10
UniProt:O14595 CTDSP2	1	CTDSP2 [nucleoplasm] (R-HSA-535488)	0.581	3
UniProt:Q06986	1	SIAH2 [cytosol] (R-MMU-374566)	0.576	6
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.569	4
IntAct:EBI-2678840 FKBP5			0.564	2
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.564	2
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.547	2
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.544	4
UniProt:Q06830 PRDX1	3	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198)	0.544	3
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.544	4
UniProt:P20794 MAK			0.537	5
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.532	4
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.527	2
UniProt:Q9BY66-3 KDM5D			0.524	2
UniProt:P78543 BTG2	1	BTG2 [cytosol] (R-HSA-6798008)	0.524	4
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.524	3
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.519	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.508	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.508	2
UniProt:P20711 DDC	1	PXLP-DDC [cytosol] (R-HSA-209810)	0.508	2
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.508	3
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.499	3
UniProt:Q9UBS8 RNF14	1	RNF14 [cytosol] (R-HSA-5688974)	0.499	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.499	2
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.483	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.471	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.471	2
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.471	2
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.471	2
UniProt:Q6KC79 NIPBL	1	NIPBL [nucleoplasm] (R-HSA-2506879)	0.471	2
UniProt:Q9Y253 POLH	2	MonoUb-K682,K686,K694,K709-POLH [nucleoplasm] (R-HSA-5655163) POLH [nucleoplasm] (R-HSA-110287)	0.471	2
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.454	2

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