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SOX17 [nucleoplasm]
Stable Identifier
R-HSA-5625834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor SOX-17, SOX17_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
Beta-catenin binds SOX proteins (Homo sapiens)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
TCF:Beta-catenin binds SOX proteins (Homo sapiens)
SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SOX17 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H6I2 SOX17
Gene Names
SOX17
Chain
chain:1-414
Reference Genes
BioGPS Gene:64321 SOX17
COSMIC (genes):SOX17 SOX17
CTD Gene:64321 SOX17
dbSNP Gene:64321 SOX17
ENSEMBL:ENSG00000164736.6 SOX17
HGNC:18122 SOX17
KEGG Gene (Homo sapiens):64321 SOX17
Monarch:64321 SOX17
NCBI Gene:64321 SOX17
OMIM:610928 SOX17
UCSC:Q9H6I2 SOX17
Reference Transcript
RefSeq:NM_022454.3 SOX17
Other Identifiers
11743872_a_at
11743873_x_at
11743874_a_at
17068972
219993_PM_at
219993_at
230943_PM_at
230943_at
3098550
3098551
3098552
3098554
3098555
3098556
3098557
3098558
3098559
3098560
55547_at
61415_at
63045_at
64321
8146462
A_14_P202396
A_23_P82775
A_24_P46946
GE63173
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001525
GO:0001570
GO:0001656
GO:0001706
GO:0001714
GO:0001828
GO:0001947
GO:0003142
GO:0003143
GO:0003151
GO:0003308
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0007283
GO:0007369
GO:0007492
GO:0007493
GO:0007507
GO:0008013
GO:0009653
GO:0010467
GO:0010628
GO:0016055
GO:0021903
GO:0022414
GO:0023019
GO:0023052
GO:0030154
GO:0030163
GO:0030178
GO:0030308
GO:0031648
GO:0035050
GO:0035987
GO:0042074
GO:0043226
GO:0043565
GO:0045595
GO:0045732
GO:0045893
GO:0045944
GO:0045995
GO:0048568
GO:0048617
GO:0048856
GO:0048863
GO:0048866
GO:0048870
GO:0050821
GO:0060214
GO:0060913
GO:0060914
GO:0060956
GO:0061009
GO:0061010
GO:0061031
GO:0061629
GO:0072091
GO:0072189
GO:0090090
GO:0140110
GO:1903226
GO:1990830
GO:2000035
GO:2000043
GO:2000738
HMNXSV003033224
Hs.98367.0.A1_3p_at
ILMN_1671092
PH_hs_0022233
TC08000376.hg
g11967990_3p_at
Participates
as an output of
Expression of SOX17 in definitive endoderm (Homo sapiens)
as a member of
SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Expression of E-cadherin (CDH1) in definitive endoderm
(Homo sapiens)
Inferred To
Sox17 [nucleoplasm]
(Mus musculus)
Sox17 [nucleoplasm]
(Rattus norvegicus)
sox17a [nucleoplasm]
(Xenopus tropicalis)
SOX17 [nucleoplasm]
(Bos taurus)
SOX17 [nucleoplasm]
(Canis familiaris)
SOX17 [nucleoplasm]
(Danio rerio)
SOX17 [nucleoplasm]
(Gallus gallus)
SOX17 [nucleoplasm]
(Sus scrofa)
Sox15 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_071899.1
OpenTargets
ENSG00000164736
GeneCards
Q9H6I2
HPA
ENSG00000164736-SOX17
Ensembl
ENSP00000297316
,
ENSG00000164736
,
ENST00000297316
PRO
Q9H6I2
Pharos - Targets
Q9H6I2
Orphanet
20717
PDB
4A3N
,
2YUL
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.499
2
UniProt:Q12857 NFIA
1
NFIA [nucleoplasm]
(R-HSA-60134)
0.471
2
UniProt:O00712 NFIB
1
NFIB [nucleoplasm]
(R-HSA-60136)
0.471
2
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