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HIP1 [cytosol]
Stable Identifier
R-HSA-8868153
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Huntingtin-interacting protein 1, HIP1_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
HIP1 dimer [cytosol] (Homo sapiens)
HIP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00291 HIP1
Gene Names
HIP1
Chain
chain:1-1037
Reference Genes
BioGPS Gene:3092 HIP1
COSMIC (genes):HIP1 HIP1
CTD Gene:3092 HIP1
dbSNP Gene:3092 HIP1
ENSEMBL:ENSG00000127946 HIP1
ENSEMBL_homo_sapiens_GENE:ENSG00000127946 HIP1
HGNC:4913 HIP1
KEGG Gene (Homo sapiens):3092 HIP1
Monarch:3092 HIP1
NCBI Gene:3092 HIP1
OMIM:601767 HIP1
UCSC:O00291 HIP1
Reference Transcript
RefSeq:NM_001243198.2 HIP1
RefSeq:NM_005338.6 HIP1
RefSeq:XM_011516116.2 HIP1
RefSeq:XM_005250304.2 HIP1
Other Identifiers
0002260075
11734760_at
11734761_a_at
11734762_at
11734763_at
11759141_at
13606
15334
16402
17058826
17964
205425_at
205426_s_at
226364_at
2NO2
2QA7
3057372
3057373
3057374
3057375
3057376
3057377
3057378
3057379
3057380
3057382
3057383
3057384
3057385
3057386
3057387
3057389
3057390
3057391
3057392
3057393
3057394
3057395
3057396
3057397
3057398
3057399
3057400
3057402
3057404
3057406
3057408
3057410
3057411
3057412
3057413
3057414
3057415
3057416
3057417
3057421
3057426
3092
3I00
41061_at
51980_at
8140319
A_23_P71033
A_24_P363548
A_24_P55391
A_24_P916314
AAC33564
AAC51257
AAI10546
AAL87037
AC004491
AC018720
AC211429
AF365404
AH006397
AHA56631
AK304738
BAG65499
BC110545
C9JMG5
CAA70574
CAB015334
CAB016402
CCDS34669
CCDS59060
ENSG00000127946
ENSP00000336747
ENSP00000410300
ENSP00000484528
ENST00000336926
ENST00000434438
ENST00000616821
EntrezGene:3092
g12545385_3p_at
g2072422_3p_a_at
GE60472
GO:0003674
GO:0003779
GO:0005154
GO:0005198
GO:0005200
GO:0005515
GO:0005543
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0006810
GO:0006897
GO:0006915
GO:0006919
GO:0007010
GO:0007015
GO:0007165
GO:0008092
GO:0008150
GO:0008219
GO:0008289
GO:0012505
GO:0016020
GO:0016192
GO:0022607
GO:0030100
GO:0030122
GO:0030136
GO:0030154
GO:0030276
GO:0030479
GO:0030665
GO:0030674
GO:0031234
GO:0031410
GO:0032051
GO:0032266
GO:0032991
GO:0035091
GO:0035254
GO:0035612
GO:0035615
GO:0042803
GO:0042981
GO:0043167
GO:0043226
GO:0043231
GO:0043325
GO:0045211
GO:0045742
GO:0046982
GO:0048260
GO:0048268
GO:0050821
GO:0051015
GO:0051897
GO:0061024
GO:0065003
GO:0072583
GO:0080025
GO:0097190
GO:0098793
GO:0098794
GO:0098888
GO:0098890
GO:0098978
GO:0099637
GO:2000588
HGNC:4913
HIP1
HIP1-201
HIP1-204
HIP1-207
HPA013606
HPA017964
Hs.38489.0.A1_3p_at
ILMN_1697787
ILMN_1701403
IPR002558
IPR008942
IPR011417
IPR013809
IPR030224
IPR030554
IPR032422
IPR035964
KF437291
KF495977
MIM:176807
MIM:601767
NM_001243198
NM_005338
NP_001230127
NP_005329
PF01608
PF07651
PF16515
PH_hs_0030302
SM00273
SM00307
TC07001534.hg
U79734
U79734_at
uc003uds.4
uc011kfz.4
uc064emn.1
UPI000013D65F
UPI0001B7922A
UPI000387BD47
XM_005250304
XM_005250305
XM_011516116
XM_017012099
XP_005250361
XP_005250362
XP_011514418
XP_016867588
Y09420
Participant Of
hasComponent
HIP1 dimer [cytosol]
Inferred To
HIP1 [cytosol] (Bos taurus)
HIP1 [cytosol] (Caenorhabditis elegans)
HIP1 [cytosol] (Canis familiaris)
HIP1 [cytosol] (Danio rerio)
HIP1 [cytosol] (Drosophila melanogaster)
HIP1 [cytosol] (Gallus gallus)
HIP1 [cytosol] (Mus musculus)
HIP1 [cytosol] (Rattus norvegicus)
HIP1 [cytosol] (Sus scrofa)
HIP1 [cytosol] (Taeniopygia guttata)
HIP1 [cytosol] (Xenopus tropicalis)
Homologues of HIP1 [cytosol] (Caenorhabditis elegans)
Homologues of HIP1 [cytosol] (Canis familiaris)
Homologues of HIP1 [cytosol] (Danio rerio)
Homologues of HIP1 [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
NP_005329.3
,
NP_001230127.1
,
XP_005250361.1
,
XP_011514418.1
OpenTargets
ENSG00000127946
GeneCards
O00291
DOCK Blaster
3I00
,
2NO2
,
2QA7
PRO
O00291
PDB
2QA7
,
3I00
,
2NO2
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.681
4
UniProt:O14641 DVL2
5
p-DVL2 [cytosol]
(R-HSA-201706)
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
UniProt:Q08426 EHHADH
2
EHHADH [cytosol]
(R-HSA-9033147)
EHHADH [peroxisomal matrix]
(R-HSA-400155)
0.488
2
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