Reactome | KRTAP1-1 [cytosol]

KRTAP1-1 [cytosol]

Stable Identifier

R-HSA-6809855

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 1-1, KRA11_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP1s [cytosol] (Homo sapiens)
        
        KRTAP1-1 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP1s [cytosol] (Homo sapiens)
        
        KRTAP1-1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07627 KRTAP1-1

Gene Names

KRTAP1-1, B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1

Chain

chain:1-177

Reference Genes

BioGPS Gene:81851 KRTAP1-1

COSMIC (genes):KRTAP1-1 KRTAP1-1

CTD Gene:81851 KRTAP1-1

dbSNP Gene:81851 KRTAP1-1

ENSEMBL:ENSG00000188581 KRTAP1-1

ENSEMBL:ENSG00000262808 KRTAP1-1

HGNC:16772 KRTAP1-1

KEGG Gene (Homo sapiens):81851 KRTAP1-1

Monarch:81851 KRTAP1-1

NCBI Gene:81851 KRTAP1-1

OMIM:608819 KRTAP1-1

UCSC:Q07627 KRTAP1-1

Reference Transcript

RefSeq:NM_030967.2 KRTAP1-1

Other Identifiers

0006550537

11738405_a_at

11738406_x_at

11753499_a_at

16844572

220976_s_at

3756691

3756696

3756697

3756698

3756699

3756700

3756701

3756702

8015196

8019578

81851

A_23_P141624

A_24_P151005

GE483411

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0008150

GO:0030154

GO:0031424

GO:0043226

GO:0045095

GO:0048856

HMNXSV003048325

Hs.247935.0.S1_3p_s_at

ILMN_1657962

ILMN_1669119

ILMN_2209260

ILMN_3251708

PH_hs_0013128

TC17001482.hg

TC17002903.hg

X63337_at

g13569941_3p_s_at

Participates

as a member of

KRTAP1s [cytosol] (Homo sapiens)

Inferred To

Homologues of KRTAP1-1 [cytosol] (Bos taurus)

Homologues of KRTAP1-1 [cytosol] (Canis familiaris)

Homologues of KRTAP1-1 [cytosol] (Mus musculus)

Homologues of KRTAP1-1 [cytosol] (Rattus norvegicus)

Homologues of KRTAP1-1 [cytosol] (Sus scrofa)

Krtap1-4 [cytosol] (Mus musculus)

Krtap1-1 [cytosol] (Rattus norvegicus)

Krtap1-3 [cytosol] (Mus musculus)

Krtap1-3 [cytosol] (Rattus norvegicus)

Krtap9-3 [cytosol] (Mus musculus)

LOC102151268 [cytosol] (Canis familiaris)

LOC100365588 [cytosol] (Rattus norvegicus)

KRTAP1-1 [cytosol] (Bos taurus)

KRTAP1-1 [cytosol] (Canis familiaris)

KRTAP1-1 [cytosol] (Sus scrofa)

LOC618495 [cytosol] (Bos taurus)

LOC102151604 [cytosol] (Canis familiaris)

Krtap1-5 [cytosol] (Mus musculus)

Krtap1-5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_112229.1

OpenTargets

ENSG00000188581

GeneCards

Q07627

HPA

ENSG00000188581-KRTAP1-1

Ensembl

ENSP00000305975, ENSP00000460787, ENSG00000262808, ENST00000573871, ENSG00000188581, ENST00000306271

PRO

Q07627

Pharos - Targets

Q07627

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.556	3
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.556	3
UniProt:Q8TCT0 CERK	1	CERK [plasma membrane] (R-HSA-1631584)	0.556	3
UniProt:Q9UBP5 HEY2	1	HEY2 [nucleoplasm] (R-HSA-1606745)	0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1(30-390) [Golgi lumen] (R-HSA-114705)	0.556	3
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) CRY2 [cytosol] (R-HSA-400255) p-S-CRY2 [nucleoplasm] (R-HSA-400328) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q9UBR2 CTSZ	9	CTSZ [ficolin-1-rich granule lumen] (R-HSA-6801318) CTSZ [Golgi lumen] (R-HSA-434321) (Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689727) CTSZ [specific granule lumen] (R-HSA-6801304) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen] (R-HSA-5689431) (Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689730) CTSZ [plasma membrane] (R-HSA-2022345) CTSZ [extracellular region] (R-HSA-6801569) CTSZ [lysosomal lumen] (R-HSA-429814)	0.556	3
UniProt:Q9NS75 CYSLTR2	2	CYSLTR1,2 [plasma membrane] (R-HSA-163618) CYSLTR2 [plasma membrane] (R-HSA-416399)	0.556	3
UniProt:O60259 KLK8	3	proKLK8 [extracellular region] (R-HSA-8850832) KLK8 [extracellular region] (R-HSA-8850833) KLK8 propeptide [extracellular region] (R-HSA-8850829)	0.556	3
UniProt:Q9Y5Y2 NUBP2	1	NUBP2 [cytosol] (R-HSA-2564767)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P07438 MT1B	1	MT1B [cytosol] (R-HSA-5660371)	0.556	3
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.556	3
UniProt:Q99895 CTRC	1	CTRC [extracellular region] (R-HSA-5693362)	0.556	3
UniProt:P48645 NMU	1	NMU [extracellular region] (R-HSA-964817)	0.556	3
UniProt:O43559 FRS3	3	p-Y-FRS3 [plasma membrane] (R-HSA-9032427) p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482)	0.556	3
UniProt:P43897 TSFM	1	TSFM [mitochondrial matrix] (R-HSA-5389837)	0.556	3
UniProt:P09603 CSF1	4	p-CSF1 [endoplasmic reticulum lumen] (R-HSA-8956881) CSF1 [plasma membrane] (R-HSA-389148) CSF1 [endoplasmic reticulum lumen] (R-HSA-8956778) CSF1 [extracellular region] (R-HSA-9009484)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [endocytic vesicle membrane] (R-HSA-2239453) SCARF1 [plasma membrane] (R-HSA-2197636)	0.556	3
UniProt:P62857 RPS28	2	RPS28 [nucleoplasm] (R-HSA-6791202) RPS28 [cytosol] (R-HSA-72365)	0.556	3
UniProt:Q9NP91 SLC6A20	2	SLC6A20 [plasma membrane] (R-HSA-352058) SLC6A20 T199M [plasma membrane] (R-HSA-5660705)	0.556	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.556	3
UniProt:P43353 ALDH3B1	3	ALDH3B1 [secretory granule membrane] (R-HSA-6801023) ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [specific granule membrane] (R-HSA-6799510)	0.556	3
UniProt:P01308 INS	20	6xHC-INS(25-110) [endoplasmic reticulum lumen] (R-HSA-265075) Insulin Glulisine B Chain [extracellular region] (R-HSA-429465) 2xHC-INS(25-54) [secretory granule lumen] (R-HSA-264902) 6xHC-INS(25-110) [Golgi lumen] (R-HSA-264890) 2xHC-Myri-INS(25-53) [extracellular region] (R-HSA-429343) 6xHC-INS(25-110) [transport vesicle] (R-HSA-6808712) 6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807734) Insulin Glargine A Chain [extracellular region] (R-HSA-429369) INS(25-110) [endoplasmic reticulum lumen] (R-HSA-264893) Insulin Glargine B Chain [extracellular region] (R-HSA-429347) INS(57-87) [extracellular region] (R-HSA-265157) 6xHC-INS(25-110) [secretory granule lumen] (R-HSA-264984) Insulin Aspart B Chain [extracellular region] (R-HSA-429393) 2xHC-INS(25-56) [secretory granule lumen] (R-HSA-9023201) INS(57-89) [secretory granule lumen] (R-HSA-9023172) 4xHC-INS(90-110) [secretory granule lumen] (R-HSA-264971) Insulin Humalog B Chain [extracellular region] (R-HSA-429397) 4xHC-INS(57-110) [secretory granule lumen] (R-HSA-9023174) 2xHC-INS(25-54) [secretory granule lumen] (R-HSA-9023157) INS(57-87) [secretory granule lumen] (R-HSA-265011)	0.556	3
UniProt:O75093 SLIT1	1	SLIT1 [extracellular region] (R-HSA-204359)	0.556	3
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.556	3
UniProt:Q8N370 SLC43A2	1	SLC43A2 [plasma membrane] (R-HSA-352109)	0.556	3
UniProt:Q92608 DOCK2	3	DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [cytosol] (R-HSA-200938)	0.556	3

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