Reactome | APIP [cytosol]

APIP [cytosol]

Stable Identifier

R-HSA-1237171

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96GX9 APIP

Gene Names

APIP, CGI-29

Chain

chain:1-242

Reference Genes

BioGPS Gene:51074 APIP

COSMIC (genes):APIP APIP

CTD Gene:51074 APIP

dbSNP Gene:51074 APIP

ENSEMBL:ENSG00000149089 APIP

ENSEMBL_homo_sapiens_GENE:ENSG00000149089.13 APIP

HGNC:17581 APIP

KEGG Gene (Homo sapiens):51074 APIP

Monarch:51074 APIP

NCBI Gene:51074 APIP

OMIM:612491 APIP

UCSC:Q96GX9 APIP

Reference Transcript

RefSeq:NM_015957.3 APIP

Other Identifiers

11720834_a_at

11748557_a_at

16737298

218698_PM_at

218698_at

3183716

3183717

3183719

3183720

3369250

3369251

3369252

3369255

3369256

3369259

3369260

3369262

3369265

3369273

3369274

51074

56219_at

7947490

GE58627

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0006520

GO:0006790

GO:0006915

GO:0008270

GO:0008652

GO:0009086

GO:0012501

GO:0016829

GO:0019284

GO:0019509

GO:0023052

GO:0042802

GO:0043066

GO:0046570

GO:0046872

GO:0051289

GO:0065003

GO:0070269

GO:0070372

HMNXSV003013698

ILMN_2128293

TC11001548.hg

g7705723_3p_at

Participates

as a component of

as an input of

APAF1:CYCS binds APIP (Homo sapiens)

This entity regulates

Negatively

CYCS:APAF1 binds procaspase-9 (Homo sapiens)

Inferred To

APIP [cytosol] (Bos taurus)

APIP [cytosol] (Canis familiaris)

APIP [cytosol] (Danio rerio)

APIP [cytosol] (Drosophila melanogaster)

APIP [cytosol] (Gallus gallus)

APIP [cytosol] (Mus musculus)

APIP [cytosol] (Rattus norvegicus)

APIP [cytosol] (Sus scrofa)

APIP [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_057041.2

OpenTargets

ENSG00000149089

HPA

ENSG00000149089-APIP

GeneCards

Q96GX9

Ensembl

ENSG00000149089, ENSP00000379133, ENST00000395787

PRO

Q96GX9

Pharos - Targets

Q96GX9

HMDB Protein

HMDBP11841

PDB

4M6R

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.888	12
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.83	11
UniProt:Q6ZVK8 NUDT18			0.712	4
UniProt:Q96HA8 NTAQ1			0.666	5
UniProt:Q17RL8 Q17RL8			0.666	4
UniProt:O14787 TNPO2			0.666	4
UniProt:Q9Y3Q8 T22D4			0.666	4
UniProt:P38182	12	ATG8 [cytosol] (R-SCE-5205651) ATG8 [cytosol] (R-SCE-5205676) ATG8 [cytosol] (R-SCE-975521) ATG8 [cytosol] (R-SCE-5679223) ATG8 [cytosol] (R-SCE-5682696) ATG8 [cytosol] (R-SCE-5682674) ATG8 [cytosol] (R-SCE-5682653) ATG8 [cytosol] (R-SCE-5682681) ATG8 [autophagosome membrane] (R-SCE-5683634) ATG8 [autophagosome membrane] (R-SCE-5683638) ATG8 [autophagosome membrane] (R-SCE-5683640) ATG8 [autophagosome membrane] (R-SCE-5683641)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	5
UniProt:Q8IYR0 CF206			0.556	3
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.556	3
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:P24278 ZBT25			0.556	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.556	3
UniProt:Q9UIF8 BAZ2B			0.556	3
UniProt:P40454 PTPA1			0.556	3
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.556	3
UniProt:Q86SG7 LYG2			0.527	2
UniProt:P0DPA2 VSIG8			0.527	2
UniProt:Q6MZM0 HPHL1			0.527	2
UniProt:Q9GZT8 NIF3L			0.488	2

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