Reactome | pro-PSMB8 [cytosol]

pro-PSMB8 [cytosol]

Stable Identifier

R-HSA-9908127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Precursor of immunoproteasome subunit beta-5i

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28062 PSMB8

Gene Names

PSMB8, LMP7, PSMB5i, RING10, Y2

Chain

propeptide:1-72, chain:73-276

Reference Genes

BioGPS Gene:5696 PSMB8

COSMIC (genes):PSMB8 PSMB8

CTD Gene:5696 PSMB8

dbSNP Gene:5696 PSMB8

ENSEMBL:ENSG00000204264 PSMB8

HGNC:9545 PSMB8

KEGG:hsa:5696 PSMB8

Monarch:5696 PSMB8

NCBI Gene:5696 PSMB8

OMIM:177046 PSMB8

UCSC:P28062 PSMB8

Reference Transcript

Participates

as an input of

Formation of the inner ring of the 20S immunoproteasome core particle (Homo sapiens)

as a component of

Immature 20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)

Other forms of this molecule

PSMB8 [cytosol]

PSMB8(1-72) [cytosol]

PSMB8 [nucleoplasm]

Inferred To

Homologues of pro-PSMB8 [cytosol] (Drosophila melanogaster)

pbs-5 [cytosol] (Caenorhabditis elegans)

Psmb8 [cytosol] (Mus musculus)

Psmb8 [cytosol] (Rattus norvegicus)

psmB5 [cytosol] (Dictyostelium discoideum)

Prosbeta5 [cytosol] (Drosophila melanogaster)

psmb8a [cytosol] (Danio rerio)

Prosbeta5R2 [cytosol] (Drosophila melanogaster)

pro-PSMB8 [cytosol] (Plasmodium falciparum)

PRE2 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of pro-PSMB8 [cytosol] (Gallus gallus)

Ghost homologue of pro-PSMB8 [cytosol] (Sus scrofa)

PSMB8 [cytosol] (Bos taurus)

PSMB8 [cytosol] (Canis familiaris)

Prosbeta5R1 [cytosol] (Drosophila melanogaster)

pts1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_004150.1, NP_683720.2

ZINC - World Drugs

PSB8_HUMAN

Guide to Pharmacology - Targets

2408

OpenTargets

ENSG00000204264

ENSEMBL

ENST00000374881, ENST00000374882, ENSP00000372723, ENSP00000402406, ENSP00000392693, ENSP00000372725, ENST00000416564, ENSP00000394155, ENSP00000404585, ENSG00000236443, ENST00000452573, ENSG00000235715, ENST00000429645, ENSP00000407539, ENST00000435978, ENSP00000408825, ENST00000436627, ENSG00000230669, ENSG00000231631, ENSG00000204264, ENST00000421445, ENST00000416134, ENST00000438442, ENSP00000364016, ENST00000455660, ENSG00000230034, ENSP00000364015, ENSG00000226201, ENSP00000412618, ENSP00000406797, ENSG00000206298, ENSP00000397057, ENSP00000414731, ENST00000441960, ENST00000383238, ENSP00000414770, ENST00000383236, ENST00000457261

ZINC - FDA approved

PSB8_HUMAN

ZINC - Substances

PSB8_HUMAN

ZINC target

P28062

PRO

P28062

GlyGen

P28062

PDB

5L5U, 6AVO, 5L5T, 5L5P, 5L5Q, 5L5F, 5L5A, 6E5B, 5L5V, 5L5O, 5L5E, 5M2B, 7AWE, 5L5R, 7B12, 5L5J, 5L5D, 5LTT, 5L5B, 5L5S, 5L5I, 5L5H

ZINC - Investigational

PSB8_HUMAN

GeneCards

PSMB8

HPA

ENSG00000204264-PSMB8

Pharos - Targets

P28062

Orphanet

PSMB8

ZINC - Predictions - Purchasable

PSB8_HUMAN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.643	7
UniProt:P27958-PRO_0000037573			0.581	4
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	2
UniProt:Q9H078 CLPB			0.527	2
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.527	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.483	2

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