Reactome | COG6 [Golgi membrane]

COG6 [Golgi membrane]

Stable Identifier

R-HSA-2980958

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Conserved oligomeric Golgi complex subunit 6, COG6_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG6 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG6 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG6 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG6 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG6 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG6 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2V7 COG6

Gene Names

COG6, KIAA1134

Chain

chain:1-657

Reference Genes

BioGPS Gene:57511 COG6

COSMIC (genes):COG6 COG6

CTD Gene:57511 COG6

dbSNP Gene:57511 COG6

ENSEMBL:ENSG00000133103 COG6

HGNC:18621 COG6

KEGG:hsa:57511 COG6

Monarch:57511 COG6

NCBI Gene:57511 COG6

OMIM:606977 COG6

UCSC:Q9Y2V7 COG6

Reference Transcript

Other Identifiers

11724048_a_at

11724049_a_at

11739210_at

16774188

225769_PM_at

225769_at

232786_PM_at

232786_at

3486384

3486385

3486386

3486387

3486388

3486389

3486390

3486391

3486392

3486393

3486394

3486395

3486396

3486397

3486400

3486401

3486402

3486403

3486404

3486408

3486412

3486413

3486414

3486417

3486418

3486419

3486425

3486426

3486427

3486428

3486429

3486430

3486435

3486436

3486441

48586_at

57511

7968711

84000_at

A_14_P102773

A_14_P105706

A_14_P113837

A_23_P53866

A_24_P290692

GE79281

GE87975

GO:0000139

GO:0000301

GO:0005515

GO:0005794

GO:0006891

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0043226

GO:0070085

HMNXSV003035609

HMNXSV003046217

Hs.18282.0.S1_3p_at

Hs.18282.1.S1_3p_at

ILMN_1779530

PH_hs_0025461

PH_hs_0041065

TC13000137.hg

TC13001031.hg

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG6 [trans-Golgi network membrane]

Inferred To

cog6 [Golgi membrane] (Dictyostelium discoideum)

cog6 [Golgi membrane] (Schizosaccharomyces pombe)

cog6 [Golgi membrane] (Xenopus tropicalis)

Cog6 [Golgi membrane] (Drosophila melanogaster)

Cog6 [Golgi membrane] (Mus musculus)

Cog6 [Golgi membrane] (Rattus norvegicus)

COG6 [Golgi membrane] (Bos taurus)

COG6 [Golgi membrane] (Canis familiaris)

COG6 [Golgi membrane] (Gallus gallus)

COG6 [Golgi membrane] (Sus scrofa)

cogc-6 [Golgi membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000356576, ENSP00000348983, ENST00000455146, ENSP00000397441, ENST00000416691, ENSP00000403733

OpenTargets

ENSG00000133103

HPA

ENSG00000133103-COG6

PRO

Q9Y2V7

Pharos - Targets

Q9Y2V7

Orphanet

COG6

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.696	5
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q9BV20 MRI1	1	MRI1 [cytosol] (R-HSA-1237095)	0.556	3
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.527	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.527	2
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.527	2
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.527	2
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.527	2
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2