Reactome | GSDMD [cytosol]

GSDMD [cytosol]

Stable Identifier

R-HSA-6801577

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gasdermin-D, GSDMD_HUMAN

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External Reference Information

External Reference

UniProt:P57764 GSDMD

Gene Names

GSDMD, DFNA5L, GSDMDC1, FKSG10

Chain

chain:1-484, chain:1-290, chain:1-275, chain:1-87, chain:276-484

Reference Genes

BioGPS Gene:79792 GSDMD

COSMIC (genes):GSDMD GSDMD

CTD Gene:79792 GSDMD

dbSNP Gene:79792 GSDMD

ENSEMBL:ENSG00000104518 GSDMD

HGNC:25697 GSDMD

KEGG:hsa:79792 GSDMD

Monarch:79792 GSDMD

NCBI Gene:79792 GSDMD

OMIM:617042 GSDMD

UCSC:P57764 GSDMD

Reference Transcript

Other Identifiers

11741138_a_at

11760110_x_at

17073370

218154_PM_at

218154_at

3119657

3119658

3119660

3119661

3119662

3119663

3119664

3119665

3119666

3119667

3119668

3119669

3119670

3119671

3119672

3119673

3119674

3119675

3119676

3119677

3119678

3119679

3119680

3119681

3119682

3119683

3119684

3119685

3119686

65139_at

65140_at

79792

8148642

A_14_P131372

A_14_P132308

A_23_P112103

A_33_P3384312

GE61932

GO:0001778

GO:0001786

GO:0002376

GO:0005515

GO:0005546

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006629

GO:0006954

GO:0008289

GO:0009306

GO:0012501

GO:0012505

GO:0016020

GO:0022829

GO:0031966

GO:0032731

GO:0035580

GO:0035655

GO:0042742

GO:0044546

GO:0045087

GO:0046513

GO:0046931

GO:0050729

GO:0050829

GO:0050830

GO:0051260

GO:0051604

GO:0055085

GO:0061024

GO:0061702

GO:0065003

GO:0070269

GO:0070273

GO:0070300

GO:0070498

GO:0072559

GO:0098542

GO:0141201

GO:1901612

GO:1904724

GO:1904813

HMNXSV003001098

HMNXSV003034638

HMNXSV003044886

ILMN_1665428

PH_hs_0006565

TC08000824.hg

g13376057_3p_at

Participates

as an input of

as an output of

GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)

Other forms of this molecule

GSDMD(1-275) [cytosol]

GSDMD(1-87) [cytosol]

GSDMD(88-484) [cytosol]

dithiocarb-C191-GSDMD(1-275) [cytosol]

GSDMD(269-484) [cytosol]

GSDMD(1-268) [cytosol]

GSDMD(276-484) [cytosol]

S-(2-succinyl)-C191-GSDMD [cytosol]

GSDMD [tertiary granule lumen]

GSDMD [extracellular region]

GSDMD [specific granule lumen]

GSDMD [ficolin-1-rich granule lumen]

Inferred To

GSDMD [cytosol] (Bos taurus)

GSDMD [cytosol] (Canis familiaris)

GSDMD [cytosol] (Sus scrofa)

Gsdmd [cytosol] (Mus musculus)

Gsdmd [cytosol] (Rattus norvegicus)

GSDMA [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001159709.1, NP_079012.3

Guide to Pharmacology - Targets

3278

OpenTargets

ENSG00000104518

ENSEMBL

ENST00000526406, ENSP00000262580, ENSG00000104518, ENST00000631751, ENSG00000278718, ENSP00000482096, ENST00000262580, ENSP00000488012, ENST00000615119, ENSP00000433209

HPA

ENSG00000104518-GSDMD

GeneCards

GSDMD

PRO

P57764

Pharos - Targets

P57764

PDB

6KN0, 7Z1X, 5WQT, 5NH1, 6AO4, 6VFE, 6N9O

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.781	7
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.659	13
UniProt:P29466 CASP1	5	CASP1(1-404) [cytosol] (R-HSA-448692) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(1-119) [cytosol] (R-HSA-448680)	0.591	4
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96NG5 ZNF558	1	ZNF558 [nucleoplasm] (R-HSA-1973893)	0.556	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q86U10 ASPG	1	ASPG [cytosol] (R-HSA-6797634)	0.556	3
UniProt:Q86T24 ZBTB33	1	ZBTB33 [nucleoplasm] (R-HSA-5223282)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.483	2

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