Reactome | DEF6 [cytosol]

DEF6 [cytosol]

Stable Identifier

R-HSA-9691487

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Differentially expressed in FDCP 6 homolog, DEFI6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H4E7 DEF6

Gene Names

DEF6, IBP

Chain

chain:1-631

Reference Genes

BioGPS Gene:50619 DEF6

COSMIC (genes):DEF6 DEF6

CTD Gene:50619 DEF6

dbSNP Gene:50619 DEF6

ENSEMBL:ENSG00000023892 DEF6

HGNC:2760 DEF6

Monarch:50619 DEF6

NCBI Gene:50619 DEF6

OMIM:610094 DEF6

UCSC:Q9H4E7 DEF6

Reference Transcript

RefSeq:NM_022047.3 DEF6

Other Identifiers

11733389_a_at

17007795

221293_PM_s_at

221293_s_at

226659_PM_at

226659_at

2904564

2904565

2904567

2904568

2904570

2904571

2904574

2904575

2904576

2904578

2904579

2904580

2904581

2904582

2904583

2904584

2904585

2904587

2904588

2904589

2904590

2904591

2904592

50619

53906_at

8118932

A_23_P321913

A_33_P3353073

GE80146

GE86304

GO:0005085

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0016020

GO:0016192

GO:0030175

GO:0042995

GO:0043226

GO:0048471

GO:0051056

GO:0098772

GO:0098876

HMNXSV003021386

Hs.15476.0.S1_3p_at

PH_hs_0027084

TC06000513.hg

g11545748_3p_a_at

Participates

as a candidate of

as a member of

RAC2 GEFs [cytosol] (Homo sapiens)

Inferred To

Def6 [cytosol] (Mus musculus)

Def6 [cytosol] (Rattus norvegicus)

F1NH72 [cytosol] (Gallus gallus)

Q54LN3 [cytosol] (Dictyostelium discoideum)

def6 [cytosol] (Danio rerio)

def6 [cytosol] (Xenopus tropicalis)

DEF6 [cytosol] (Canis familiaris)

DEF6 [cytosol] (Sus scrofa)

A0A3Q1MKN5 [cytosol] (Bos taurus)

Cross References

ENSEMBL

ENST00000316637, ENSP00000319831

OpenTargets

ENSG00000023892

HPA

ENSG00000023892-DEF6

PRO

Q9H4E7

Pharos - Targets

Q9H4E7

HMDB Protein

HMDBP11500

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:O95391 SLU7	1	hSLU7 [nucleoplasm] (R-HSA-72073)	0.556	3
UniProt:Q8WZA2 RAPGEF4	1	RAPGEF4 [plasma membrane] (R-HSA-3008666)	0.556	3
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.527	2
UniProt:Q00653 NFKB2	6	NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) p-7S-p100 [cytosol] (R-HSA-5607629) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) NFKB2(1-900) [cytosol] (R-HSA-2677931) monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500)	0.527	3
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.527	2
UniProt:Q04759 PRKCQ	9	p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) PRKCQ [plasma membrane] (R-HSA-202346) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [cytosol] (R-HSA-58216) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ(1-354) [cytosol] (R-HSA-212526) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997)	0.527	2
UniProt:Q7Z4W1 DCXR	2	DCXR H195Tfs*7 [plasma membrane] (R-HSA-5662854) DCXR [plasma membrane] (R-HSA-5660054)	0.527	2

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