Reactome | TDO2 [cytosol]

TDO2 [cytosol]

Stable Identifier

R-HSA-71184

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

tryptophan 2,3-dioxygenase, tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase, Tryptophan oxygenase, Tryptamin 2,3-dioxygenase, TRPO

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48775 TDO2

Gene Names

TDO2, TDO

Chain

chain:1-406

Reference Genes

BioGPS Gene:6999 TDO2

COSMIC (genes):TDO2 TDO2

CTD Gene:6999 TDO2

dbSNP Gene:6999 TDO2

ENSEMBL:ENSG00000151790 TDO2

ENSEMBL:ENSG00000262635 TDO2

HGNC:11708 TDO2

KEGG Gene (Homo sapiens):6999 TDO2

Monarch:6999 TDO2

NCBI Gene:6999 TDO2

OMIM:191070 TDO2

UCSC:P48775 TDO2

Reference Transcript

RefSeq:NM_005651.3 TDO2

Other Identifiers

0000670138

11755822_a_at

16971758

205943_at

2749021

2749022

2749024

2749025

2749027

2749028

2749030

2749031

2749032

2749035

2749036

2749038

2749039

2749041

2749042

38606_at

6999

8097991

A_14_P117363

A_23_P80974

GE61964

GO:0003674

GO:0004833

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006520

GO:0006568

GO:0006569

GO:0006790

GO:0008150

GO:0009056

GO:0016491

GO:0016597

GO:0019441

GO:0019442

GO:0019825

GO:0020037

GO:0022607

GO:0034641

GO:0042802

GO:0043167

GO:0044281

GO:0046872

GO:0051186

GO:0051213

GO:0051289

GO:0055114

GO:0065003

GO:1904842

ILMN_1716859

ILMN_2172091

PH_hs_0010828

TC04000789.hg

U32989_at

g5032164_3p_at

Participant Of

hasComponent

TDO2 tetramer [cytosol]

Inferred To

TDO2 [cytosol] (Canis familiaris)

TDO2 [cytosol] (Gallus gallus)

TDO2 [cytosol] (Sus scrofa)

tdo [cytosol] (Dictyostelium discoideum)

tdo-2 [cytosol] (Caenorhabditis elegans)

tdo2a [cytosol] (Danio rerio)

tdo2 [cytosol] (Xenopus tropicalis)

v [cytosol] (Drosophila melanogaster)

Tdo2 [cytosol] (Mus musculus)

Tdo2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_005642.1

OpenTargets

ENSG00000151790

HPA

ENSG00000151790-TDO2

GeneCards

P48775

Ensembl

ENST00000536354, ENSP00000444788, ENSG00000151790, ENSP00000460086, ENSG00000262635, ENST00000573403

ZINC target

P48775

PRO

P48775

Orphanet

24996

HMDB Protein

HMDBP05537

PDB

5TI9, 5TIA, 6A4I, 6PYY, 6VBN, 6PYZ, 4PW8

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.781	7
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.666	4
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3

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