Reactome | TDO2 [cytosol]

TDO2 [cytosol]

Stable Identifier

R-HSA-71184

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

tryptophan 2,3-dioxygenase, tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase, Tryptophan oxygenase, Tryptamin 2,3-dioxygenase, TRPO

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48775 TDO2

Gene Names

TDO2, TDO

Chain

chain:1-406

Reference Genes

BioGPS Gene:6999 TDO2

COSMIC (genes):TDO2 TDO2

CTD Gene:6999 TDO2

dbSNP Gene:6999 TDO2

ENSEMBL:ENSG00000151790 TDO2

ENSEMBL:ENSG00000151790.9 TDO2

ENSEMBL:ENSG00000262635.5 TDO2

HGNC:11708 TDO2

KEGG Gene (Homo sapiens):6999 TDO2

Monarch:6999 TDO2

NCBI Gene:6999 TDO2

OMIM:191070 TDO2

UCSC:P48775 TDO2

Reference Transcript

RefSeq:NM_005651.3 TDO2

Other Identifiers

0000670138

11755822_a_at

16971758

205943_PM_at

205943_at

2749021

2749022

2749024

2749025

2749027

2749028

2749030

2749031

2749032

2749035

2749036

2749038

2749039

2749041

2749042

38606_at

6999

8097991

A_14_P117363

A_23_P80974

GE61964

GO:0004833

GO:0005515

GO:0005622

GO:0005737

GO:0005829

GO:0006520

GO:0006568

GO:0006569

GO:0006790

GO:0016491

GO:0016597

GO:0019441

GO:0019442

GO:0019825

GO:0020037

GO:0042802

GO:0046872

GO:0051213

GO:0051289

GO:0055086

GO:0065003

GO:1901135

GO:1904842

HMNXSV003055056

ILMN_1716859

ILMN_2172091

PH_hs_0010828

TC04000789.hg

U32989_at

g5032164_3p_at

Participates

as a component of

TDO2 tetramer [cytosol] (Homo sapiens)

Inferred To

TDO2 [cytosol] (Bos taurus)

TDO2 [cytosol] (Caenorhabditis elegans)

TDO2 [cytosol] (Canis familiaris)

TDO2 [cytosol] (Danio rerio)

TDO2 [cytosol] (Dictyostelium discoideum)

TDO2 [cytosol] (Drosophila melanogaster)

TDO2 [cytosol] (Gallus gallus)

TDO2 [cytosol] (Mus musculus)

TDO2 [cytosol] (Rattus norvegicus)

TDO2 [cytosol] (Sus scrofa)

TDO2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005642.1

Guide to Pharmacology - Targets

2887

OpenTargets

ENSG00000151790

GeneCards

P48775

HPA

ENSG00000151790-TDO2

ZINC target

P48775

Ensembl

ENSP00000444788, ENSG00000151790, ENSG00000262635, ENST00000536354, ENST00000573403, ENSP00000460086

PRO

P48775

Pharos - Targets

P48775

Orphanet

24996

HMDB Protein

HMDBP05537

PDB

5TIA, 6VBN, 4PW8, 6PYY, 6UD5, 6PYZ, 5TI9, 6A4I

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.781	7
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.666	4
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3

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