Reactome | PSMB9 [cytosol]

PSMB9 [cytosol]

Stable Identifier

R-HSA-68765

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Immunoproteasome subunit beta-1i, Proteasome subunit beta type 9, Proteasome subunit beta type 9 precursor , Proteasome chain 7, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, RING12 protein, Low molecular mass protein 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28065 PSMB9

Gene Names

PSMB9, LMP2, PSMB6i, RING12

Chain

propeptide:1-20, chain:21-219

Reference Genes

BioGPS Gene:5698 PSMB9

COSMIC (genes):PSMB9 PSMB9

CTD Gene:5698 PSMB9

dbSNP Gene:5698 PSMB9

ENSEMBL:ENSG00000240065 PSMB9

HGNC:9546 PSMB9

KEGG:hsa:5698 PSMB9

Monarch:5698 PSMB9

NCBI Gene:5698 PSMB9

OMIM:177045 PSMB9

UCSC:P28065 PSMB9

Reference Transcript

RefSeq:NM_002800.4 PSMB9

Other Identifiers

11726677_a_at

11735623_a_at

11761758_at

17007307

17028360

17033661

17038644

204279_PM_at

204279_at

2903286

2903298

2903304

2903305

2903306

2903307

2903308

2903309

2903310

2903311

2903312

2903313

2903314

2903315

2903316

2903318

2903319

38287_at

5698

8118571

8178211

8179495

A_14_P109897

A_21_P0010486

A_23_P111000

GE60353

GE728820

GO:0000502

GO:0002376

GO:0003824

GO:0004175

GO:0004298

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006508

GO:0016787

GO:0019774

GO:0030163

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:0140096

GO:1990111

GO:2000116

HMNXSV003043627

HMNXSV003054514

ILMN_1798233

ILMN_2376108

PH_hs_0013087

PH_hs_0018571

PH_hs_0033030

TC06004082.hg

TC6_apd_hap1000122.hg

TC6_cox_hap2000259.hg

TC6_dbb_hap3000226.hg

TC6_mann_hap4000190.hg

TC6_mcf_hap5000202.hg

TC6_qbl_hap6000215.hg

TC6_ssto_hap7000193.hg

X66401_cds1_at

g4506204_3p_at

p30027

Participates

as a component of

Other forms of this molecule

pro-PSMB9 [cytosol]

PSMB9(1-20) [cytosol]

Inferred To

pbs-1 [cytosol] (Caenorhabditis elegans)

psmb9a [cytosol] (Danio rerio)

bPSMB9 [cytosol] (Bos taurus)

Prosbeta1 [cytosol] (Drosophila melanogaster)

psmB6 [cytosol] (Dictyostelium discoideum)

pre3 [cytosol] (Schizosaccharomyces pombe)

PRE3 [cytosol] (Saccharomyces cerevisiae)

PSMB9 [cytosol] (Canis familiaris)

PSMB9 [cytosol] (Plasmodium falciparum)

PSMB9 [cytosol] (Sus scrofa)

Psmb9 [cytosol] (Mus musculus)

Psmb9 [cytosol] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2409

OpenTargets

ENSG00000240065

ENSEMBL

ENSP00000372595, ENST00000422729, ENSP00000412027, ENSP00000407233, ENSG00000240118, ENSG00000239836, ENSG00000243958, ENST00000374859, ENSP00000407810, ENST00000427870, ENSG00000240508, ENST00000444284, ENSG00000243594, ENSP00000396813, ENSP00000363993, ENSG00000243067, ENSG00000242711, ENSP00000372721, ENST00000453059, ENSG00000240065, ENST00000383114, ENST00000383234, ENST00000434471, ENSP00000393744

GeneCards

PSMB9

HPA

ENSG00000240065-PSMB9

ZINC - Substances

PSB9_HUMAN

ZINC target

P28065

PRO

P28065

Pharos - Targets

P28065

GlyGen

P28065

ZINC - Predictions - Purchasable

PSB9_HUMAN

PDB

9FST, 7B12, 7AWE, 6E5B, 6AVO

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.798	10
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.738	6
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.643	5
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	6
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.643	5
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.643	5
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.643	5
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.643	4
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.643	5
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.643	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.643	6
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008)	0.643	5
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.643	6
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.643	5
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.643	5
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.643	5
UniProt:Q14657 LAGE3	1	LAGE3 [nucleoplasm] (R-HSA-6784525)	0.601	4
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [cytosol] (R-HSA-416633) GRIP1 [plasma membrane] (R-HSA-416638)	0.581	3
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.581	3
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.581	3
UniProt:Q24JT5 Q24JT5			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.527	4
UniProt:Q9P0P0 RNF181	1	RNF181 [cytoplasm] (R-HSA-8939317)	0.527	3
UniProt:Q9GZU8 PIP30			0.527	4
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.527	2
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.527	4
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.527	4
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926)	0.527	3
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.527	3
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	4
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.527	4
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.527	4
UniProt:Q9NX31 OSER1			0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	3
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994)	0.527	4
UniProt:P06732 CKM	1	CKM [cytosol] (R-HSA-200350)	0.527	2
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	4
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.527	4
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.527	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.527	4
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	4
UniProt:Q5JS54 PSMG4	1	PSMG4 [cytosol] (R-HSA-9908036)	0.527	4
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.527	5
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.527	4
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.527	4
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:Q9WMX2-PRO_0000037548			0.508	2

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