Reactome | KCTD6 [cytosol]

KCTD6 [cytosol]

Stable Identifier

R-HSA-8863321

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BTB/POZ domain-containing protein KCTD6, KCTD6_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KCTD6 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
22573887	Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover Chen, J, Lange, S, Teh, P, Perera, S	Mol. Biol. Cell	2012

External Reference Information

External Reference

UniProt:Q8NC69 KCTD6

Gene Names

KCTD6

Chain

chain:1-237

Reference Genes

BioGPS Gene:200845 KCTD6

COSMIC (genes):KCTD6 KCTD6

CTD Gene:200845 KCTD6

dbSNP Gene:200845 KCTD6

ENSEMBL:ENSG00000168301 KCTD6

ENSEMBL_homo_sapiens_GENE:ENSG00000168301.13 KCTD6

HGNC:22235 KCTD6

KEGG Gene (Homo sapiens):200845 KCTD6

Monarch:200845 KCTD6

NCBI Gene:200845 KCTD6

OMIM:618791 KCTD6

UCSC:Q8NC69 KCTD6

Reference Transcript

Other Identifiers

11726443_a_at

16942239

200845

238001_PM_at

238001_at

238077_PM_at

238077_at

2626265

2626266

2626268

2626271

2626272

2626273

2626274

2626276

2626277

76919_at

8080804

A_14_P103310

A_14_P128347

A_14_P138263

A_23_P385246

GE530334

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0008092

GO:0016567

GO:0023052

GO:0030163

GO:0030506

GO:0031430

GO:0036211

GO:0042802

GO:0043226

GO:0045879

GO:0051260

GO:0065003

GO:0097602

HMNXSV003022318

Hs.13982.0.S1_3p_at

Hs.13982.1.A1_3p_at

ILMN_1800942

ILMN_2146372

PH_hs_0001339

TC03000379.hg

Participates

as an output of

KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)

as a member of

BTB proteins [cytosol] (Homo sapiens)

Inferred To

kctd6 [cytosol] (Danio rerio)

kctd6 [cytosol] (Xenopus tropicalis)

Ktl [cytosol] (Drosophila melanogaster)

KCTD6 [cytosol] (Bos taurus)

KCTD6 [cytosol] (Caenorhabditis elegans)

KCTD6 [cytosol] (Canis familiaris)

KCTD6 [cytosol] (Dictyostelium discoideum)

KCTD6 [cytosol] (Gallus gallus)

KCTD6 [cytosol] (Sus scrofa)

Kctd6 [cytosol] (Mus musculus)

Kctd6 [cytosol] (Rattus norvegicus)

Homologues of KCTD6 [cytosol] (Caenorhabditis elegans)

Homologues of KCTD6 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

XP_005264994.1, NP_699162.3, NP_001121686.1

OpenTargets

ENSG00000168301

HPA

ENSG00000168301-KCTD6

GeneCards

Q8NC69

Ensembl

ENSG00000168301, ENSP00000347188, ENSP00000417490, ENST00000355076, ENSP00000384948, ENST00000490264, ENST00000404589

PRO

Q8NC69

Pharos - Targets

Q8NC69

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.871	13
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.849	10
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.827	9
UniProt:P57764 GSDMD	13	GSDMD [tertiary granule lumen] (R-HSA-6801501) GSDMD [specific granule lumen] (R-HSA-6801468) GSDMD [extracellular region] (R-HSA-6801576) GSDMD [ficolin-1-rich granule lumen] (R-HSA-6801498) GSDMD(88-484) [cytosol] (R-HSA-9686133) GSDMD(1-87) [cytosol] (R-HSA-9686099) dithiocarb-C191-GSDMD(1-275) [cytosol] (R-HSA-9693317) GSDMD(1-275) [cytosol] (R-HSA-9647641) GSDMD [cytosol] (R-HSA-6801577) GSDMD(269-484) [cytosol] (R-HSA-9710116) GSDMD(1-268) [cytosol] (R-HSA-9710104) GSDMD(276-484) [cytosol] (R-HSA-9647672) S-(2-succinyl)-C191-GSDMD [cytosol] (R-HSA-9716198)	0.781	7
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.743	6
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.718	6
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.666	4
UniProt:Q9H5Z6 F124B			0.556	3
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.556	3
UniProt:B2R8Y4 B2R8Y4			0.556	3
UniProt:O60716-29 CTNND1			0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q9H7E9 CH033			0.556	3
UniProt:O60716-5 CTNND1			0.556	3
UniProt:Q14451-3 GRB7			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	6
UniProt:Q08AF8 GOG8F			0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:Q0D2H9 GOG8D			0.556	3
UniProt:Q13427 PPIG	2	PPIG [cytosol] (R-HSA-9728768) PPIG [nucleoplasm] (R-HSA-9769592)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q9BYX2-5 TBC1D2			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	3
UniProt:Q9HBF4 ZFYV1			0.527	2
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.527	2
UniProt:Q13325 IFIT5	1	IFIT5 [cytosol] (R-HSA-9684472)	0.527	2