Reactome | Psma1 [nucleoplasm]

Psma1 [nucleoplasm]

Stable Identifier

R-MMU-9008778

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha-6, PSA1_MOUSE

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R1P4 Psma1

Gene Names

Psma1

Chain

chain:1-263

Reference Genes

BioGPS Gene:26440 Psma1

KEGG:mmu:26440 Psma1

Monarch:26440 Psma1

NCBI Gene:26440 Psma1

UCSC:Q9R1P4 Psma1

Reference Transcript

RefSeq:NM_011965.2 Psma1

Other Identifiers

10338071

10338120

10338473

10338636

10338963

10338968

10338995

10339324

10339471

10339523

10339949

10340335

10340822

10340974

10341145

10341203

10341761

10341795

10341880

10341921

10342081

10342147

10342727

10342779

10342997

10343203

10343233

10343578

10343968

10344586

10567072

1415695_at

1458292_at

17203273

17203275

17203277

17203279

17203281

17203283

17203285

17203287

17203289

17203291

17203301

17203303

17203307

17203309

17203311

17203313

17203315

17203317

17203319

17203321

17495297

26440

4305781

4351594

4394024

4562191

4587412

4598072

4632918

4635862

4672402

4866189

4866258

4928983

4978708

5011969

5029464

5047991

5051391

5058925

5070373

5146925

5216178

5218375

5256013

5298516

5302789

5313087

5370909

5380370

5396884

5443593

5481895

5560099

5560216

5593705

5599443

5607129

96892_at

A_51_P469578

A_66_P117014

GE37220

GO:0000502

GO:0001530

GO:0002376

GO:0002862

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005839

GO:0006511

GO:0008289

GO:0010498

GO:0019773

GO:0030163

GO:0043161

GO:0043226

GO:0051603

ILMN_2777591

mMC010462

Participates

as a component of

Other forms of this molecule

Psma1 [cytosol]

Inferred From

PSMA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_036095.1

ENSEMBL

ENSMUST00000033008, ENSMUSP00000033008

PRO

Q9R1P4

GlyGen

Q9R1P4

MGI

1347005

PDB

3UNH, 3UNF, 3UNE, 3UNB

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) NOTCH3(1572-2321) [Golgi membrane] (R-HSA-156995) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) NICD3 [nucleoplasm] (R-HSA-157928) NICD3 [cytosol] (R-HSA-157647) NEXT3 [plasma membrane] (R-HSA-157203) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517)	0.508	2
UniProt:Q91X58 ZFN2B			0.499	2