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RGS19 [plasma membrane]
Stable Identifier
R-HSA-921129
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 19, RGS19_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (z) [plasma membrane] (Homo sapiens)
RGS19 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49795 RGS19
Gene Names
RGS19, GAIP, GNAI3IP
Chain
chain:1-217
Reference Genes
BioGPS Gene:10287 RGS19
COSMIC (genes):RGS19 RGS19
CTD Gene:10287 RGS19
dbSNP Gene:10287 RGS19
ENSEMBL:ENSG00000171700 RGS19
HGNC:13735 RGS19
KEGG:hsa:10287 RGS19
Monarch:10287 RGS19
NCBI Gene:10287 RGS19
OMIM:605071 RGS19
UCSC:P49795 RGS19
Reference Transcript
RefSeq:NM_005873.3 RGS19
RefSeq:XM_047439824.1 RGS19
RefSeq:XM_054322826.1 RGS19
RefSeq:XM_011528486.2 RGS19
RefSeq:XM_011528485.3 RGS19
RefSeq:XM_054322827.1 RGS19
RefSeq:NM_001039467.2 RGS19
Other Identifiers
10287
11718915_a_at
16921433
204336_PM_s_at
204336_s_at
34268_at
3914308
3914309
3914310
3914311
3914312
3914313
3914314
3914315
3914316
3914317
3914318
3914319
3914320
3914321
3914322
3914323
3914324
3914325
3914326
8067802
A_23_P257014
A_33_P3211956
GE60145
GO:0003824
GO:0003924
GO:0005515
GO:0005794
GO:0005886
GO:0006914
GO:0007186
GO:0007264
GO:0009968
GO:0016020
GO:0016787
GO:0043226
HMNXSV003020766
ILMN_1677085
PH_hs_0019765
TC20001046.hg
TC20001720.hg
X91809_at
g5031704_3p_a_at
p26767
Participates
as a member of
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
as a candidate of
RGS proteins active for G alpha (z) [plasma membrane] (Homo sapiens)
Inferred To
rgs-1 [plasma membrane]
(Caenorhabditis elegans)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
RGS19 [plasma membrane]
(Bos taurus)
RGS19 [plasma membrane]
(Canis familiaris)
RGS19 [plasma membrane]
(Dictyostelium discoideum)
RGS19 [plasma membrane]
(Gallus gallus)
RGS19 [plasma membrane]
(Sus scrofa)
rgs-2 [plasma membrane]
(Caenorhabditis elegans)
Dhit [plasma membrane]
(Drosophila melanogaster)
RGS2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
Rgs19 [plasma membrane]
(Mus musculus)
Rgs19 [plasma membrane]
(Rattus norvegicus)
Homologues of RGS19 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS19 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RGS19 [plasma membrane]
(Saccharomyces cerevisiae)
rgs19 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001034556.1
,
XP_047295780.1
,
NP_005864.1
,
XP_054178802.1
,
XP_054178801.1
,
XP_011526787.1
,
XP_011526788.1
Guide to Pharmacology - Targets
2802
ENSEMBL
ENSP00000333194
,
ENST00000332298
,
ENST00000395042
,
ENSG00000171700
,
ENSP00000378483
OpenTargets
ENSG00000171700
GeneCards
RGS19
HPA
ENSG00000171700-RGS19
PRO
P49795
Pharos - Targets
P49795
PDB
1CMZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
3
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