Reactome | PSMB4 [nucleoplasm]

PSMB4 [nucleoplasm]

Stable Identifier

R-HSA-174343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta type 4, Proteasome subunit beta type 4 precursor , Proteasome beta chain, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome chain 3, HSN3, HsBPROS26

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28070 PSMB4

Gene Names

PSMB4, PROS26

Chain

propeptide:1-45, chain:46-264

Reference Genes

BioGPS Gene:5692 PSMB4

COSMIC (genes):PSMB4 PSMB4

CTD Gene:5692 PSMB4

dbSNP Gene:5692 PSMB4

ENSEMBL:ENSG00000159377 PSMB4

HGNC:9541 PSMB4

KEGG:hsa:5692 PSMB4

Monarch:5692 PSMB4

NCBI Gene:5692 PSMB4

OMIM:602177 PSMB4

UCSC:P28070 PSMB4

Reference Transcript

RefSeq:NM_002796.2 PSMB4

Other Identifiers

11715407_s_at

11715408_x_at

11754271_a_at

1311_at

16670850

202243_PM_s_at

202243_s_at

202244_PM_at

202244_at

2358907

2358908

2358909

2358910

2358911

2358912

2358913

2358914

2358915

2358916

2358917

2358918

2358919

2358920

2358921

2358922

2358923

2358925

33154_at

5692

7905395

A_14_P133049

A_23_P761

D26600_at

GE81194

GO:0000502

GO:0001530

GO:0002862

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005815

GO:0005829

GO:0005839

GO:0008289

GO:0019774

GO:0030163

GO:0036064

GO:0043161

GO:0043226

GO:0051603

GO:0070062

HMNXSV003013847

ILMN_1737862

PH_hs_0004994

TC01001209.hg

g4506198_3p_at

Participates

as a component of

20S CP inner ring [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMB4 [cytosol]

pro-PSMB4 [cytosol]

PSMB4(1-45) [cytosol]

Inferred To

pbs-7 [nucleoplasm] (Caenorhabditis elegans)

PRE4 [nucleoplasm] (Saccharomyces cerevisiae)

Prosbeta7 [nucleoplasm] (Drosophila melanogaster)

Psmb4 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of PSMB4 [nucleoplasm] (Canis familiaris)

Ghost homologue of PSMB4 [nucleoplasm] (Danio rerio)

Ghost homologue of PSMB4 [nucleoplasm] (Sus scrofa)

Ghost homologue of PSMB4 [nucleoplasm] (Xenopus tropicalis)

PSMB4 [nucleoplasm] (Bos taurus)

PSMB4 [nucleoplasm] (Gallus gallus)

PSMB4 [nucleoplasm] (Schizosaccharomyces pombe)

psmB4-1; psmB4-2 [nucleoplasm] (Dictyostelium discoideum)

Proteasome subunit beta type-4 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_002787.2

OpenTargets

ENSG00000159377

ENSEMBL

ENST00000290541, ENSP00000290541, ENSG00000159377

GeneCards

PSMB4

HPA

ENSG00000159377-PSMB4

PRO

P28070

Pharos - Targets

P28070

GlyGen

P28070

PDB

9E8G, 6KWY, 5LEX, 5LF3, 5T0C, 7LXV, 7QYA, 6E5B, 5LF0, 5LF7, 5LF1, 7NAN, 7AWE, 5VFQ, 7QXU, 4R3O, 7W3G, 6MSH, 7W3I, 8CXB, 5A0Q, 6MSG, 6WJN, 7QXW, 6WJD, 7W37, 9E8O, 5VFS, 7W38, 9E8Q, 6REY, 6XMJ, 6MSK, 5LE5, 7NAQ, 7V5G, 5LN3, 8UD9, 5M32, 5T0G, 5T0J, 7NAO, 8CVR, 7W3M, 7W3K, 6MSE, 7QXP, 7QXN, 8QYN, 5GJQ, 6R70, 8BZL, 5LF4, 5LEY, 4R67, 8CVT, 5LF6, 5LEZ, 5L4G, 7QYB, 8TM6, 8CVS, 7W3J, 7W3H, 7W3B, 5VFR, 6RGQ, 7W3A, 6MSB, 5VFU, 5VFP, 6AVO, 5GJR, 7W39, 7NHT, 5VFT, 6MSJ, 7PG9, 8QYO, 8QYS, 7V5M, 5T0H, 5T0I, 7NAP, 7B12, 7W3F, 6MSD, 7QXX, 7W3C, 7QY7, 5VFO

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.896	14
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.8	9
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.798	6
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.788	8
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.752	6
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.725	5
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.725	5
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.725	6
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.666	5
UniProt:Q15797 SMAD1	4	p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.666	4
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.659	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.643	4
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.643	4
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.643	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.638	3
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q8TDC0 MYOZ3			0.556	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.556	3
UniProt:Q7Z6R9 TFAP2D	1	TFAP2D [nucleoplasm] (R-HSA-5626817)	0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q96M29 TEKT5			0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q9Y5R4 HEMK1			0.556	3
UniProt:P28676 GCA	2	GCA [extracellular region] (R-HSA-6806174) GCA [azurophil granule lumen] (R-HSA-6799167)	0.556	3
UniProt:Q9H987-2 SYNPO2L			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:O75360 PROP1			0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:Q5JUK2 SOLH1			0.556	3
UniProt:Q13148 TADBP			0.556	3
UniProt:Q08117-2 TLE5			0.556	5
UniProt:Q99697-2 PITX2			0.556	3
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.527	3
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.527	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	3
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	3
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.527	2
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	4
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.527	2
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.527	3
UniProt:P28062 PSMB8	4	PSMB8 [cytosol] (R-HSA-68762) pro-PSMB8 [cytosol] (R-HSA-9908127) PSMB8(1-72) [cytosol] (R-HSA-9908131) PSMB8 [nucleoplasm] (R-HSA-174336)	0.527	2
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4

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