Reactome | PSMB4 [nucleoplasm]

PSMB4 [nucleoplasm]

Stable Identifier

R-HSA-174343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta type 4, Proteasome subunit beta type 4 precursor , Proteasome beta chain, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome chain 3, HSN3, HsBPROS26

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMB4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28070 PSMB4

Gene Names

PSMB4, PROS26

Chain

propeptide:1-45, chain:46-264

Reference Genes

BioGPS Gene:5692 PSMB4

COSMIC (genes):PSMB4 PSMB4

CTD Gene:5692 PSMB4

dbSNP Gene:5692 PSMB4

ENSEMBL:ENSG00000159377.11 PSMB4

HGNC:9541 PSMB4

KEGG Gene (Homo sapiens):5692 PSMB4

Monarch:5692 PSMB4

NCBI Gene:5692 PSMB4

OMIM:602177 PSMB4

UCSC:P28070 PSMB4

Reference Transcript

RefSeq:NM_002796.2 PSMB4

Other Identifiers

0002970577

11715407_s_at

11715408_x_at

11754271_a_at

1311_at

16670850

202243_PM_s_at

202243_s_at

202244_PM_at

202244_at

2358907

2358908

2358909

2358911

2358912

2358913

2358914

2358916

2358919

2358921

2358923

33154_at

5692

7905395

A_23_P761

D26600_at

GE81194

GO:0000502

GO:0001530

GO:0002376

GO:0002862

GO:0003674

GO:0004298

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005815

GO:0005829

GO:0005839

GO:0005856

GO:0005929

GO:0006954

GO:0008150

GO:0008233

GO:0008289

GO:0010498

GO:0019774

GO:0030163

GO:0032991

GO:0036064

GO:0043161

GO:0043226

GO:0051603

GO:0070062

ILMN_1737862

PH_hs_0004994

g4506198_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMB4 [cytosol]

Inferred To

pbs-7 [nucleoplasm] (Caenorhabditis elegans)

psmB4-1 [nucleoplasm] (Dictyostelium discoideum)

Prosbeta7 [nucleoplasm] (Drosophila melanogaster)

Psmb4 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of PSMB4 [nucleoplasm] (Sus scrofa)

PSMB4 [nucleoplasm] (Bos taurus)

PSMB4 [nucleoplasm] (Canis familiaris)

PSMB4 [nucleoplasm] (Danio rerio)

PSMB4 [nucleoplasm] (Gallus gallus)

psmb4 [nucleoplasm] (Xenopus tropicalis)

Proteasome subunit beta type-4 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_002787.2

OpenTargets

ENSG00000159377

HPA

ENSG00000159377-PSMB4

GeneCards

P28070

Ensembl

ENST00000290541, ENSG00000159377, ENSP00000290541

PRO

P28070

Pharos - Targets

P28070

Orphanet

24830

PDB

6MSH, 6RGQ, 5T0C, 5A0Q, 4R67, 5T0G, 5GJR, 6MSJ, 5T0H, 7AWE, 5LF1, 5LF0, 5VFP, 5VFO, 6R70, 6MSB, 6MSD, 5VFQ, 6MSE, 4R3O, 6AVO, 5LE5, 7NHT, 6MSG, 6REY, 5LEZ, 5T0J, 6XMJ, 5T0I, 6MSK, 5LF4, 5VFS, 6WJD, 7LXV, 5VFR, 5L4G, 5LF3, 5LEX, 7V5M, 6WJN, 6KWY, 7PG9, 5VFU, 7V5G, 7B12, 5LF7, 5LN3, 5GJQ, 5VFT, 5LF6, 5M32, 5LEY, 6E5B

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.495	2