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PSMB10 [cytosol]
Stable Identifier
R-HSA-68741
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Immunoproteasome subunit beta-2i, Proteasome subunit beta type 10, Proteasome subunit beta type 10 precursor , Proteasome MECl-1, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)
Proteasomal clevage of exogenous antigen (immunoproteasome catalyst) (Homo sapiens)
Immunoproteasome [cytosol] (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst) (Homo sapiens)
Immunoproteasome [cytosol] (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
Antigen processing: Ub, ATP-independent proteasomal degradation (Homo sapiens)
Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) (Homo sapiens)
Immunoproteasome [cytosol] (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Proteasome assembly (Homo sapiens)
Formation of the immunoproteasome (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
Immunoproteasome [cytosol] (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
Maturation of the 20S immunoproteasome core particle (Homo sapiens)
20S immunoproteasome core particle [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
Maturation of the 20S thymoproteasome core particle (Homo sapiens)
20S thymoproteasome core particle [cytosol] (Homo sapiens)
20S CP thymoproteasome inner ring [cytosol] (Homo sapiens)
PSMB10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40306 PSMB10
Gene Names
PSMB10, LMP10, MECL1
Chain
propeptide:1-39, chain:40-273
Reference Genes
BioGPS Gene:5699 PSMB10
COSMIC (genes):PSMB10 PSMB10
CTD Gene:5699 PSMB10
dbSNP Gene:5699 PSMB10
ENSEMBL:ENSG00000205220 PSMB10
HGNC:9538 PSMB10
KEGG:hsa:5699 PSMB10
Monarch:5699 PSMB10
NCBI Gene:5699 PSMB10
OMIM:176847 PSMB10
UCSC:P40306 PSMB10
Reference Transcript
RefSeq:NM_002801.3 PSMB10
Other Identifiers
11716640_a_at
11716641_x_at
11753939_x_at
16827483
202659_PM_at
202659_at
3696015
3696017
3696018
3696019
3696020
3696021
3696022
3696023
3696024
3696025
3696026
3696027
3696028
3696029
3696031
3696032
3696033
3696034
384_at
5699
8002133
A_23_P140807
A_33_P3288359
GE61663
GE86457
GO:0000502
GO:0000902
GO:0002376
GO:0003824
GO:0004175
GO:0004298
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006508
GO:0006959
GO:0016787
GO:0019774
GO:0030163
GO:0042098
GO:0043161
GO:0043226
GO:0051603
GO:0140096
GO:1990111
HMNXSV003006497
ILMN_1683026
PH_hs_0000997
TC16002086.hg
X71874_cds1_at
g4506190_3p_s_at
Participates
as a component of
20S CP thymoproteasome inner ring [cytosol] (Homo sapiens)
20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)
Other forms of this molecule
pro-PSMB10 [cytosol]
PSMB10(1-39) [cytosol]
Inferred To
Prosbeta2R2 [cytosol]
(Drosophila melanogaster)
PSMB10 [cytosol]
(Canis familiaris)
PSMB10 [cytosol]
(Plasmodium falciparum)
PSMB10 [cytosol]
(Sus scrofa)
Prosbeta2R1 [cytosol]
(Drosophila melanogaster)
psmb10 [cytosol]
(Danio rerio)
PUP1 [cytosol]
(Saccharomyces cerevisiae)
bPSMB10 [cytosol]
(Bos taurus)
Homologues of PSMB10 [cytosol]
(Drosophila melanogaster)
pup1 [cytosol]
(Schizosaccharomyces pombe)
Psmb10 [cytosol]
(Mus musculus)
Psmb10 [cytosol]
(Rattus norvegicus)
Prosbeta2 [cytosol]
(Drosophila melanogaster)
pbs-2 [cytosol]
(Caenorhabditis elegans)
psmB7 [cytosol]
(Dictyostelium discoideum)
Cross References
OpenTargets
ENSG00000205220
ENSEMBL
ENSP00000351314
,
ENSG00000205220
,
ENST00000358514
HPA
ENSG00000205220-PSMB10
GeneCards
PSMB10
ZINC - Substances
PSB10_HUMAN
ZINC target
P40306
PRO
P40306
Pharos - Targets
P40306
GlyGen
P40306
ZINC - Predictions - Purchasable
PSB10_HUMAN
PDB
6HVU
,
6HV4
,
6HVT
,
6AVO
,
6HV5
,
6HV7
,
9FSV
,
7B12
,
7AWE
,
6HVA
,
6E5B
,
6HVW
,
6HV3
,
6HVR
,
6HVS
,
6HVV
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95273 CCDB1
0.742
5
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.659
5
UniProt:O43186 CRX
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.547
2
UniProt:P25787 PSMA2
5
PSMA2 [cytosol]
(R-HSA-68726)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
0.527
2
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.527
2
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