Reactome | PSMB10 [cytosol]

PSMB10 [cytosol]

Stable Identifier

R-HSA-68741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Immunoproteasome subunit beta-2i, Proteasome subunit beta type 10, Proteasome subunit beta type 10 precursor , Proteasome MECl-1, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P40306 PSMB10

Gene Names

PSMB10, LMP10, MECL1

Chain

propeptide:1-39, chain:40-273

Reference Genes

BioGPS Gene:5699 PSMB10

COSMIC (genes):PSMB10 PSMB10

CTD Gene:5699 PSMB10

dbSNP Gene:5699 PSMB10

ENSEMBL:ENSG00000205220 PSMB10

HGNC:9538 PSMB10

KEGG:hsa:5699 PSMB10

Monarch:5699 PSMB10

NCBI Gene:5699 PSMB10

OMIM:176847 PSMB10

UCSC:P40306 PSMB10

Reference Transcript

RefSeq:NM_002801.3 PSMB10

Other Identifiers

11716640_a_at

11716641_x_at

11753939_x_at

16827483

202659_PM_at

202659_at

3696015

3696017

3696018

3696019

3696020

3696021

3696022

3696023

3696024

3696025

3696026

3696027

3696028

3696029

3696031

3696032

3696033

3696034

384_at

5699

8002133

A_23_P140807

A_33_P3288359

GE61663

GE86457

GO:0000502

GO:0000902

GO:0002376

GO:0003824

GO:0004175

GO:0004298

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006508

GO:0006959

GO:0016787

GO:0019774

GO:0030163

GO:0042098

GO:0043161

GO:0043226

GO:0051603

GO:0140096

GO:1990111

HMNXSV003006497

ILMN_1683026

PH_hs_0000997

TC16002086.hg

X71874_cds1_at

g4506190_3p_s_at

Participates

as a component of

Other forms of this molecule

pro-PSMB10 [cytosol]

PSMB10(1-39) [cytosol]

Inferred To

Prosbeta2R2 [cytosol] (Drosophila melanogaster)

PSMB10 [cytosol] (Canis familiaris)

PSMB10 [cytosol] (Plasmodium falciparum)

PSMB10 [cytosol] (Sus scrofa)

Prosbeta2R1 [cytosol] (Drosophila melanogaster)

psmb10 [cytosol] (Danio rerio)

PUP1 [cytosol] (Saccharomyces cerevisiae)

bPSMB10 [cytosol] (Bos taurus)

Homologues of PSMB10 [cytosol] (Drosophila melanogaster)

pup1 [cytosol] (Schizosaccharomyces pombe)

Psmb10 [cytosol] (Mus musculus)

Psmb10 [cytosol] (Rattus norvegicus)

Prosbeta2 [cytosol] (Drosophila melanogaster)

pbs-2 [cytosol] (Caenorhabditis elegans)

psmB7 [cytosol] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000205220

ENSEMBL

ENSP00000351314, ENSG00000205220, ENST00000358514

HPA

ENSG00000205220-PSMB10

GeneCards

PSMB10

ZINC - Substances

PSB10_HUMAN

ZINC target

P40306

PRO

P40306

Pharos - Targets

P40306

GlyGen

P40306

ZINC - Predictions - Purchasable

PSB10_HUMAN

PDB

6HVU, 6HV4, 6HVT, 6AVO, 6HV5, 6HV7, 9FSV, 7B12, 7AWE, 6HVA, 6E5B, 6HVW, 6HV3, 6HVR, 6HVS, 6HVV

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95273 CCDB1			0.742	5
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.659	5
UniProt:O43186 CRX			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.547	2
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.527	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	2