K63polyUb-TRAF6 [plasma membrane]

Stable Identifier
R-HSA-936980
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
K6 polyubiquitinated TRAF6
K63polyUb-TRAF6 [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17135271 Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Lamothe, B, Besse, A, Campos, AD, Webster, WK, Wu, H, Darnay, BG

J Biol Chem 2007
External Reference Information
External Reference
Gene Names
TRAF6, RNF85
Chain
chain:1-522
Other Identifiers
0002630132
0003800670
11744243_a_at
1209_at
16737401
19805
1LB4
1LB5
1LB6
205558_at
20599
2ECI
2JMD
3290612
3290616
3369891
3369892
3369893
3369894
3369895
3369896
3369898
3369899
3369902
3369903
3369904
3369905
3369906
3369907
3369913
3369914
3HCS
3HCT
3HCU
4605
4Z8M
53334_at
7189
74236_at
7947540
A_23_P75921
AAB38751
AAH31052
AAO38054
AC009656
AC061999
AK292978
AY228337
BAF85667
BC031052
CAB004605
CCDS7901
CH471064
EAW68119
EAW68120
EAW68122
ENSG00000175104
ENSP00000337853
ENSP00000433623
ENST00000348124
ENST00000526995
EntrezGene:7189
g4759253_3p_at
GE59433
GO:0000122
GO:0000187
GO:0000209
GO:0001503
GO:0001843
GO:0002223
GO:0002224
GO:0002376
GO:0002726
GO:0002755
GO:0003674
GO:0004842
GO:0005164
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005768
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006464
GO:0006810
GO:0006950
GO:0006955
GO:0006974
GO:0007155
GO:0007165
GO:0007249
GO:0007250
GO:0007254
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0009058
GO:0009790
GO:0009887
GO:0009898
GO:0010008
GO:0016567
GO:0016579
GO:0016740
GO:0019221
GO:0019886
GO:0019899
GO:0019901
GO:0030154
GO:0030316
GO:0031293
GO:0031398
GO:0031410
GO:0031435
GO:0031624
GO:0031625
GO:0031666
GO:0031996
GO:0032147
GO:0032743
GO:0032991
GO:0034162
GO:0034641
GO:0035631
GO:0038095
GO:0042088
GO:0042102
GO:0042475
GO:0042592
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043065
GO:0043066
GO:0043122
GO:0043123
GO:0043167
GO:0043226
GO:0043422
GO:0043507
GO:0045084
GO:0045410
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046849
GO:0046872
GO:0047485
GO:0048468
GO:0048471
GO:0048646
GO:0048661
GO:0048856
GO:0050852
GO:0051023
GO:0051091
GO:0051092
GO:0051865
GO:0061630
GO:0070423
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:2000679
HGNC:12036
HPA019805
HPA020599
ILMN_1700353
ILMN_1783910
ILMN_2392143
IPR001293
IPR001841
IPR002083
IPR008974
IPR012227
IPR013083
IPR017907
IPR027139
IPR037309
MIM:602355
NM_004620
NM_145803
NP_004611
NP_665802
PF02176
PF13923
PH_hs_0005066
SM00061
SM00184
TC11001560.hg
TRAF6
TRAF6-201
TRAF6-202
U78798
U78798_at
uc001mwq.3
uc001mws.3
UPI000000D924
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [plasma membrane]) at 124
Coordinate
124
Modification
K63polyUb [plasma membrane]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
OpenTargets
GeneCards
DOCK Blaster
PRO
BRENDA (Homo sapiens)
Orphanet
Interactors (67)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9Y4K3 TRAF6  8 0.914 10
 UniProt:O00463 TRAF5      0.87 14
 UniProt:Q13077 TRAF1  3 0.87 13
 UniProt:Q12933 TRAF2  5 0.861 10
 UniProt:P61088 UBE2N  5 0.847 9
 UniProt:Q86VP1 TAX1BP1  1 0.797 8
 IntAct:EBI-4399559 UBIQ      0.77 5
 UniProt:Q96CG3 TIFA      0.702 6
 UniProt:P51617 IRAK1  14 0.702 3
 UniProt:P0CG48 UBC  316 0.702 3
 UniProt:P07947 YES1  2 0.696 5
 UniProt:Q8N1B4 VPS52  1 0.696 5
 UniProt:Q13501 SQSTM1  2 0.688 4
 UniProt:Q9UDY8 MALT1  1 0.688 5
 UniProt:P62837 UBE2D2  4 0.683 4
 UniProt:Q9NYJ8 TAB2  5 0.678 3
 UniProt:O43187 IRAK2  6 0.678 3
 UniProt:O43318 MAP3K7  10 0.669 3
 UniProt:O43734 CIKS      0.666 4
 UniProt:P61077 UBE2D3  3 0.658 3
 UniProt:Q9Y616 IRAK3  1 0.635 3
 UniProt:Q9UGI0 ZRANB1  1 0.635 3
 UniProt:Q9UKE5 TNIK  1 0.591 3
 UniProt:P25942 CD40      0.59 2
 UniProt:P07174 Ngfr  1 0.589 2
 UniProt:Q99558 MAP3K14  5 0.589 2
 UniProt:P28074 PSMB5  2 0.589 2
 UniProt:P25786 PSMA1  2 0.589 2
 UniProt:Q9UNM6 PSMD13  5 0.589 2
 UniProt:Q15008 PSMD6  5 0.589 2
 UniProt:O00232 PSMD12  5 0.589 2
 UniProt:P51665 PSMD7  5 0.589 2
 UniProt:P40939 HADHA  1 0.589 2
 UniProt:P62191 PSMC1  2 0.589 2
 UniProt:P62195 PSMC5  2 0.589 2
 UniProt:Q13200 PSMD2  5 0.589 2
 UniProt:Q14257 RCN2      0.589 2
 UniProt:P55072 VCP  8 0.589 2
 UniProt:P99999 CYCS  4 0.589 2
 UniProt:P98170 XIAP  3 0.573 2
 UniProt:Q9UNA4 POLI  1 0.556 3
 UniProt:P15732  21 0.556 3
 UniProt:Q8V2D1 Q8V2D1      0.556 3
 UniProt:Q9H8W4 PKHF2      0.556 3
 UniProt:P50222 MEOX2      0.556 3
 UniProt:O75604 USP2  2 0.556 3
 UniProt:Q8WWZ3 EDARADD  1 0.556 5
 UniProt:Q8TD23 ZNF675  1 0.543 4
 UniProt:Q15750 TAB1  2 0.527 2
 UniProt:P51668 UBE2D1  3 0.527 2
 UniProt:P10221 ITP      0.524 3
 UniProt:P61964 WDR5  1 0.524 2
 UniProt:Q01220 A52      0.524 2
 UniProt:Q9C0C7-3 AMBRA1      0.499 2
 UniProt:O75385 ULK1  7 0.499 2
 UniProt:P14778 IL1R1  1 0.499 2
 UniProt:Q8IWQ3-3 BRSK2      0.488 2
 UniProt:P54725 RAD23A  1 0.488 2
 UniProt:O94888 UBXN7  1 0.488 2
 UniProt:Q9HAC8 UBTD1      0.488 2
 UniProt:Q8N3F0 MTURN      0.488 2
 UniProt:Q8NA54 IQUB      0.488 2
 UniProt:Q96DC9 OTUB2  2 0.488 2
 UniProt:Q8TBB1 LNX1  1 0.488 2
 UniProt:P24278 ZBT25      0.488 2
 UniProt:Q5VVQ6 YOD1  1 0.488 2
 UniProt:O14836 TNFRSF13B  1 0.462 2