Reactome | NME7 [cytosol]

NME7 [cytosol]

Stable Identifier

R-HSA-6806880

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nucleoside diphosphate kinase 7, NDK7_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        NME7 [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        NME7 [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        NME7 [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        NME7 [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        NME7 [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        NME7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5B8 NME7

Gene Names

NME7

Chain

chain:1-376

Reference Genes

BioGPS Gene:29922 NME7

COSMIC (genes):NME7 NME7

CTD Gene:29922 NME7

dbSNP Gene:29922 NME7

ENSEMBL:ENSG00000143156 NME7

HGNC:20461 NME7

KEGG:hsa:29922 NME7

Monarch:29922 NME7

NCBI Gene:29922 NME7

OMIM:613465 NME7

UCSC:Q9Y5B8 NME7

Reference Transcript

Other Identifiers

11745845_a_at

16696138

219553_PM_at

219553_at

227556_PM_at

227556_at

2443234

2443236

2443237

2443238

2443239

2443250

2443251

2443256

2443257

2443258

2443264

2443265

2443266

2443272

2443273

2443275

2443276

2443277

2443278

2443279

2443281

2443283

2443284

2443285

2443296

2443300

29922

7922137

A_23_P46063

A_32_P223786

GE54932

GO:0000931

GO:0003824

GO:0004550

GO:0004672

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005879

GO:0005929

GO:0006183

GO:0006228

GO:0006241

GO:0007018

GO:0008408

GO:0010968

GO:0016301

GO:0016740

GO:0016787

GO:0022414

GO:0030317

GO:0031514

GO:0036126

GO:0043226

GO:0048870

GO:0055086

GO:0140096

GO:0160111

GO:1901135

HMNXSV003044432

Hs.78629.2.A1_3p_at

ILMN_1716583

ILMN_2369286

PH_hs_0029573

TC01003495.hg

g7242158_3p_at

Participates

as a component of

gamma-tubulin complex [cytosol] (Homo sapiens)

Inferred To

nme7 [cytosol] (Xenopus tropicalis)

NME7 [cytosol] (Bos taurus)

NME7 [cytosol] (Canis familiaris)

NME7 [cytosol] (Gallus gallus)

NME7 [cytosol] (Sus scrofa)

Nme7 [cytosol] (Mus musculus)

Nme7 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000356785, ENST00000367811, ENSP00000433341, ENSG00000143156, ENST00000472647

OpenTargets

ENSG00000143156

GeneCards

NME7

HPA

ENSG00000143156-NME7

PRO

Q9Y5B8

Pharos - Targets

Q9Y5B8

Orphanet

NME7

HMDB Protein

HMDBP00110

PDB

8J07, 7UNG

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.718	6
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.718	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:O75344 FKBP6	2	FKBP6 [nucleoplasm] (R-HSA-912512) FKBP6 [cytosol] (R-HSA-5601923)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:A0MZ66 SHTN1	1	KIAA1598 [cytosol] (R-HSA-443599)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.556	5
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3