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TRAF6 [plasma membrane]
Stable Identifier
R-HSA-936955
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
IRAK1 phosphorylates Pellino (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 mediated activation of TAK1 complex (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4K3 TRAF6
Gene Names
TRAF6, RNF85
Chain
chain:1-522
Reference Genes
BioGPS Gene:7189 TRAF6
COSMIC (genes):TRAF6 TRAF6
CTD Gene:7189 TRAF6
dbSNP Gene:7189 TRAF6
ENSEMBL:ENSG00000175104 TRAF6
HGNC:12036 TRAF6
KEGG:hsa:7189 TRAF6
Monarch:7189 TRAF6
NCBI Gene:7189 TRAF6
OMIM:602355 TRAF6
UCSC:Q9Y4K3 TRAF6
Reference Transcript
RefSeq:NM_145803.2 TRAF6
RefSeq:NM_004620.3 TRAF6
Other Identifiers
11744243_a_at
1209_at
16737401
205558_PM_at
205558_at
227264_PM_at
227264_at
3290612
3290616
3369887
3369889
3369891
3369892
3369893
3369894
3369895
3369896
3369898
3369899
3369902
3369903
3369904
3369905
3369906
3369907
3369913
3369914
53334_at
61369_at
7189
74236_at
7947540
82386_at
A_23_P75921
A_32_P192984
GE59433
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002223
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0002755
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006355
GO:0006955
GO:0006974
GO:0007165
GO:0007249
GO:0008270
GO:0009887
GO:0009898
GO:0010008
GO:0016567
GO:0016740
GO:0019886
GO:0019899
GO:0023035
GO:0030154
GO:0030316
GO:0030674
GO:0031234
GO:0031398
GO:0031624
GO:0031663
GO:0031666
GO:0032147
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032991
GO:0033209
GO:0034138
GO:0034142
GO:0034450
GO:0035631
GO:0035666
GO:0038061
GO:0038095
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042475
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043226
GO:0043422
GO:0043507
GO:0045087
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046849
GO:0046872
GO:0048468
GO:0048471
GO:0048856
GO:0050852
GO:0051091
GO:0051092
GO:0051865
GO:0060090
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0098696
GO:0098978
GO:0140096
GO:0140374
GO:0141124
GO:1904996
GO:2000679
HMNXSV003018702
Hs.296272.0.A1_3p_at
ILMN_1700353
ILMN_1783910
ILMN_2392143
PH_hs_0005066
PH_hs_0037121
TC11001560.hg
TC11003120.hg
U78798_at
g4759253_3p_at
Participates
as a component of
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1 [plasma membrane] (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
TRAF6:p-IRAK2 [plasma membrane] (Homo sapiens)
p-IRAK2:oligo-TRAF6 [plasma membrane] (Homo sapiens)
Other forms of this molecule
TRAF6 [cytosol]
K63polyUb-TRAF6 [cytosol]
K63polyUb-TRAF6 [plasma membrane]
K63polyUb-TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
PolyUb-TRAF6 [cytosol]
K48polyUb-TRAF6 [cytosol]
Inferred To
TRAF6 [plasma membrane]
(Bos taurus)
TRAF6 [plasma membrane]
(Canis familiaris)
TRAF6 [plasma membrane]
(Gallus gallus)
TRAF6 [plasma membrane]
(Sus scrofa)
Traf6 [plasma membrane]
(Drosophila melanogaster)
Traf6 [plasma membrane]
(Mus musculus)
Traf6 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_665802.1
,
NP_004611.1
OpenTargets
ENSG00000175104
ENSEMBL
ENSP00000337853
,
ENST00000526995
,
ENST00000348124
,
ENSP00000433623
IntEnz
2.3.2.27
HPA
ENSG00000175104-TRAF6
PRO
Q9Y4K3
Pharos - Targets
Q9Y4K3
Orphanet
TRAF6
PDB
8HZ2
,
3HCS
,
6A33
,
3HCU
,
7L3L
,
3HCT
,
1LB5
,
1LB4
,
2JMD
,
1LB6
,
4Z8M
,
5ZUJ
,
2ECI
Interactors (77)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.939
20
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.919
11
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.905
10
UniProt:O00463 TRAF5
0.879
15
UniProt:P61088 UBE2N
5
UBE2N [cytosol]
(R-HSA-206072)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
UBE2N [nucleoplasm]
(R-HSA-5682541)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
0.847
9
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.809
5
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.797
8
UniProt:P51617 IRAK1
14
IRAK1 [cytosol]
(R-HSA-446639)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
0.77
4
IntAct:EBI-4399559 UBIQ
0.77
5
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.758
4
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.718
6
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.718
6
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.71
4
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
UBE2D2 [cytosol]
(R-HSA-934628)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
0.708
5
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.702
3
UniProt:Q96CG3 TIFA
2
TIFA [cytosol]
(R-HSA-451582)
p-T9-TIFA [cytosol]
(R-HSA-9645512)
0.702
6
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.688
5
UniProt:Q13501 SQSTM1
7
SQSTM1 [cytosol]
(R-HSA-193937)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
0.688
4
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.678
3
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.675
4
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.675
4
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.675
4
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.669
3
UniProt:Q9HAV5 EDA2R
1
EDA2R [plasma membrane]
(R-HSA-5669018)
0.669
3
UniProt:O43734 CIKS
0.666
4
UniProt:P61077 UBE2D3
3
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
UBE2D3 [cytosol]
(R-HSA-934630)
UBE2D3 [nucleoplasm]
(R-HSA-205341)
0.658
3
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.591
3
UniProt:P25942 CD40
0.59
2
UniProt:P07174 Ngfr
8
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
(R-RNO-193863)
Ngfr [nucleoplasm]
(R-RNO-197473)
Ngfr [plasma membrane]
(R-RNO-194509)
Ngfr [cytosol]
(R-RNO-194458)
Ngfr [endosome]
(R-RNO-209541)
Ngfr [plasma membrane]
(R-RNO-194476)
Ngfr [extracellular region]
(R-RNO-194470)
Ngfr [plasma membrane]
(R-RNO-193664)
0.589
2
UniProt:P28074 PSMB5
4
PSMB5 [cytosol]
(R-HSA-68753)
PSMB5 [nucleoplasm]
(R-HSA-174344)
pro-PSMB5 [cytosol]
(R-HSA-9908135)
PSMB5(1-59) [cytosol]
(R-HSA-9908134)
0.589
2
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.589
2
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.589
2
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
0.589
2
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.589
2
UniProt:O00232 PSMD12
5
PSMD12 [cytosol]
(R-HSA-68792)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
0.589
2
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
0.589
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.589
2
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.589
2
UniProt:Q14257 RCN2
0.589
2
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.589
2
UniProt:Q8IWQ3-3 BRSK2
0.556
3
UniProt:Q9UNA4 POLI
1
POLI [nucleoplasm]
(R-HSA-5656133)
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.556
3
UniProt:P43405-2 P434052
0.556
3
UniProt:P15732
2
UBC5 [cytosol]
(R-SCE-8864160-2)
UBC5 [cytosol]
(R-SCE-174236-2)
0.556
3
UniProt:Q9HAC8 UBTD1
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q8NA54 IQUB
0.556
3
UniProt:Q96DC9 OTUB2
2
OTUB2 [cytosol]
(R-HSA-933410)
OTUB2 [nucleoplasm]
(R-HSA-6783260)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
5
UniProt:P24278 ZBT25
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q8WWZ3 EDARADD
1
EDARADD [cytosol]
(R-HSA-5675659)
0.556
5
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:Q8TD23 ZNF675
1
ZNF675 [nucleoplasm]
(R-HSA-2248874)
0.543
4
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.536
2
UniProt:P99999 CYCS
6
CYCS [cytosol]
(R-HSA-53259)
CYCS [mitochondrial intermembrane space]
(R-HSA-114244)
Cytochrome c (oxidised) [mitochondrial inner membrane]
(R-HSA-352607)
Cytochrome c (reduced) [mitochondrial inner membrane]
(R-HSA-352609)
apo-CYCS [mitochondrial inner membrane]
(R-HSA-352608)
AcK-CYCS [mitochondrial intermembrane space]
(R-HSA-5688308)
0.536
2
UniProt:Q9Y3C0 WASC3
0.527
2
UniProt:Q15750 TAB1
6
TAB1 [cytosol]
(R-HSA-167923)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(445-504) [cytosol]
(R-HSA-9729691)
0.527
2
UniProt:Q9Y2V7 COG6
2
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
COG6 [Golgi membrane]
(R-HSA-2980958)
0.527
2
UniProt:Q9Y6C2 EMILIN1
1
EMILIN1 [extracellular region]
(R-HSA-2161355)
0.527
2
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.527
3
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.527
2
UniProt:Q05D60 DEUP1
0.527
2
UniProt:P10221 ITP
0.524
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.524
2
UniProt:Q01220 A52
0.524
2
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.519
2
UniProt:Q8V2D1 Q8V2D1
0.518
3
UniProt:O75385 ULK1
7
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
ULK1 [recycling endosome]
(R-HSA-8854761)
0.499
2
UniProt:P14778 IL1R1
1
IL1R1 [plasma membrane]
(R-HSA-197595)
0.499
2
UniProt:Q9C0C7-3 AMBRA1
0.499
2
UniProt:O14836 TNFRSF13B
1
TAC1 [plasma membrane]
(R-HSA-5668752)
0.462
2
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