Reactome | KRTAP1-3 [cytosol]

KRTAP1-3 [cytosol]

Stable Identifier

R-HSA-6809866

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Keratin-associated protein 1-3, KRA13_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of hair keratin fibres (Homo sapiens)
    - Keratin associated proteins [cytosol] (Homo sapiens)
      - KRTAP1s [cytosol] (Homo sapiens)
        
        KRTAP1-3 [cytosol] (Homo sapiens)
    - Keratin tonofilament:Keratin associated proteins polymer [cytosol] (Homo sapiens)
      - Keratin tonofilament, KAPs [cytosol] (Homo sapiens)
        
        Keratin associated proteins [cytosol] (Homo sapiens)
        
        KRTAP1s [cytosol] (Homo sapiens)
        
        KRTAP1-3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IUG1 KRTAP1-3

Gene Names

KRTAP1-3, B2B, KAP1.2, KAP1.3, KAP1.8, KAP1.9, KRATP1.9, KRTAP1.8

Chain

chain:1-167

Reference Genes

BioGPS Gene:81850 KRTAP1-3

COSMIC (genes):KRTAP1-3 KRTAP1-3

CTD Gene:81850 KRTAP1-3

dbSNP Gene:81850 KRTAP1-3

ENSEMBL:ENSG00000221880 KRTAP1-3

HGNC:16771 KRTAP1-3

KEGG:hsa:81850 KRTAP1-3

Monarch:81850 KRTAP1-3

NCBI Gene:81850 KRTAP1-3

OMIM:608820 KRTAP1-3

UCSC:Q8IUG1 KRTAP1-3

Reference Transcript

RefSeq:NM_030966.2 KRTAP1-3

Other Identifiers

11734622_at

16844568

220978_PM_at

220978_at

234880_PM_x_at

234880_x_at

3756690

3756691

3756692

3756693

3756697

3756700

8015189

8019585

81850

A_23_P130241

A_24_P142495

GE743028

GO:0005198

GO:0005515

GO:0005829

GO:0005882

GO:0030280

GO:0045095

HMNXSV003024327

Hs.247935.0.S1_3p_s_at

ILMN_1711628

ILMN_1776354

ILMN_2209260

PH_hs_0032303

TC17002902.hg

g13569939_3p_at

Participates

as a member of

KRTAP1s [cytosol] (Homo sapiens)

Inferred To

Krtap1-4 [cytosol] (Mus musculus)

LOC100523275 [cytosol] (Sus scrofa)

Krtap1-1 [cytosol] (Rattus norvegicus)

Krtap1-3 [cytosol] (Mus musculus)

Krtap1-3 [cytosol] (Rattus norvegicus)

Krtap9-3 [cytosol] (Mus musculus)

KRTAP1-3 [cytosol] (Bos taurus)

KRTAP1-3 [cytosol] (Canis familiaris)

KRTAP1-3 [cytosol] (Sus scrofa)

LOC102164863 [cytosol] (Sus scrofa)

Krtap1-5l1 [cytosol] (Rattus norvegicus)

KRTAP1-1 [cytosol] (Bos taurus)

Homologues of KRTAP1-3 [cytosol] (Bos taurus)

Homologues of KRTAP1-3 [cytosol] (Canis familiaris)

Homologues of KRTAP1-3 [cytosol] (Mus musculus)

Homologues of KRTAP1-3 [cytosol] (Rattus norvegicus)

Homologues of KRTAP1-3 [cytosol] (Sus scrofa)

Krtap1-5 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_112228.1

OpenTargets

ENSG00000221880

ENSEMBL

ENSG00000262347, ENSP00000344420, ENST00000344363, ENST00000575715, ENSG00000221880, ENSP00000461303

HPA

ENSG00000221880-KRTAP1-3

GeneCards

KRTAP1-3

PRO

Q8IUG1

Pharos - Targets

Q8IUG1

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.556	3
UniProt:P01308 INS	20	6xHC-INS(25-110) [Golgi lumen] (R-HSA-264890) 6xHC-INS(25-110) [secretory granule lumen] (R-HSA-264984) 2xHC-INS(25-56) [secretory granule lumen] (R-HSA-9023201) INS(57-89) [secretory granule lumen] (R-HSA-9023172) 4xHC-INS(57-110) [secretory granule lumen] (R-HSA-9023174) 6xHC-INS(25-110) [endoplasmic reticulum lumen] (R-HSA-265075) INS(57-87) [extracellular region] (R-HSA-265157) C Peptide [secretory granule lumen] (R-HSA-265011) 4xHC-INS(90-110) [secretory granule lumen] (R-HSA-264971) 2xHC-INS(25-54) [secretory granule lumen] (R-HSA-264902) INS(25-110) [endoplasmic reticulum lumen] (R-HSA-264893) Insulin Aspart B Chain [extracellular region] (R-HSA-429393) Insulin Humalog B Chain [extracellular region] (R-HSA-429397) Insulin Glulisine B Chain [extracellular region] (R-HSA-429465) 2xHC-Myri-INS(25-53) [extracellular region] (R-HSA-429343) Insulin Glargine A Chain [extracellular region] (R-HSA-429369) Insulin Glargine B Chain [extracellular region] (R-HSA-429347) 2xHC-INS(25-54) [extracellular region] (R-HSA-74673) 4xHC-INS(90-110) [extracellular region] (R-HSA-74672) INS(25-54) [endosome lumen] (R-HSA-141723)	0.556	3
UniProt:Q9UPY5 SLC7A11	1	SLC7A11 [plasma membrane] (R-HSA-378515)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.556	3
UniProt:Q49AN0 CRY2	5	CRY2 [cytosol] (R-HSA-400255) p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) K48polyUb-K126,p-S-CRY2 [cytosol] (R-HSA-9932882) K48polyUb-K,p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	5
UniProt:P22301 IL10	1	IL10 [extracellular region] (R-HSA-447125)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q86YT5 SLC13A5	1	SLC13A5 [plasma membrane] (R-HSA-433135)	0.556	3
UniProt:P42892 ECE1	1	ECE1 [plasma membrane] (R-HSA-8876866)	0.556	3
UniProt:P06850 CRH	1	CRH [extracellular region] (R-HSA-420146)	0.556	3
UniProt:Q8WUK0 DUSP23	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.556	3
UniProt:Q8IW45 NAXD	1	CARKD [mitochondrial matrix] (R-HSA-6806970)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:Q8N370 SLC43A2	1	SLC43A2 [plasma membrane] (R-HSA-352109)	0.556	3
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.556	3
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.556	3
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.556	3
UniProt:P48645 NMU	1	NMU [extracellular region] (R-HSA-964817)	0.556	3
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.556	3
UniProt:O96014 WNT11	9	N4GlycoAsn-PalmS WNT11 [extracellular region] (R-HSA-3247797) N4GlycoAsn-PalmS WNT11 [plasma membrane] (R-HSA-3247792) N4GlycoAsn-PalmS WNT11 [Golgi lumen] (R-HSA-3247823) N4GlycoAsn-PalmS WNT11 [endoplasmic reticulum lumen] (R-HSA-3238335) N4GlycoAsn-WNT11 [endoplasmic reticulum lumen] (R-HSA-3238222) WNT11 [endoplasmic reticulum lumen] (R-HSA-3238281) N4GlycoAsn-PalmS WNT11 [endocytic vesicle membrane] (R-HSA-3781987) N4GlycoAsn-PalmS WNT11 [extracellular exosome] (R-HSA-3781980) WNT11 [extracellular region] (R-HSA-517473)	0.556	3
UniProt:P43353 ALDH3B1	3	ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [specific granule membrane] (R-HSA-6799510) ALDH3B1 [secretory granule membrane] (R-HSA-6801023)	0.556	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.488	2

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