Reactome | PSMA2 [nucleoplasm]

PSMA2 [nucleoplasm]

Stable Identifier

R-HSA-174345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 2 , Proteasome component C3, Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25787 PSMA2

Gene Names

PSMA2, HC3, PSC3

Chain

initiator methionine:, chain:2-234

Reference Genes

BioGPS Gene:5683 PSMA2

COSMIC (genes):PSMA2 PSMA2

CTD Gene:5683 PSMA2

dbSNP Gene:5683 PSMA2

ENSEMBL:ENSG00000106588 PSMA2

HGNC:9531 PSMA2

KEGG:hsa:5683 PSMA2

Monarch:5683 PSMA2

NCBI Gene:5683 PSMA2

OMIM:176842 PSMA2

UCSC:P25787 PSMA2

Reference Transcript

RefSeq:NM_002787.4 PSMA2

Other Identifiers

11719275_a_at

11757361_x_at

1446_at

17057035

201316_PM_at

201316_at

201317_PM_s_at

201317_s_at

2523133

3047965

3047966

3047967

3047968

3047969

3047970

3047971

3047972

3047973

3047974

3047975

3047976

3047977

3047978

3047979

3047980

3047983

3047984

3047987

3047988

3047989

41240_at

5683

8139232

A_23_P345591

D00760_at

GE79408

GO:0000502

GO:0000932

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0009615

GO:0019773

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:1904813

HMNXSV003010728

Hs.181309.0.S2_3p_at

ILMN_2058512

PH_hs_0023846

PH_hs_0035799

TC07003353.hg

g4506180_3p_a_at

Participates

as a component of

20S CP outer ring [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA2 [cytosol]

PSMA2 [ficolin-1-rich granule lumen]

PSMA2 [extracellular region]

PSMA2 [secretory granule lumen]

Inferred To

psma2a [nucleoplasm] (Danio rerio)

PSMA2 [nucleoplasm] (Bos taurus)

PSMA2 [nucleoplasm] (Canis familiaris)

PSMA2 [nucleoplasm] (Gallus gallus)

PSMA2 [nucleoplasm] (Sus scrofa)

psma2 [nucleoplasm] (Xenopus tropicalis)

Homologues of PSMA2 [nucleoplasm] (Danio rerio)

psma2b [nucleoplasm] (Danio rerio)

Prosalpha2 [nucleoplasm] (Drosophila melanogaster)

Psma2 [nucleoplasm] (Mus musculus)

Psma2 [nucleoplasm] (Rattus norvegicus)

pas-2 [nucleoplasm] (Caenorhabditis elegans)

psmA2 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002778.1

OpenTargets

ENSG00000106588

ENSEMBL

ENSG00000106588, ENST00000223321, ENSP00000223321

GeneCards

PSMA2

HPA

ENSG00000106588-PSMA2

PRO

P25787

Pharos - Targets

P25787

GlyGen

P25787

PDB

7W37, 5M32, 6MSG, 6WJN, 7QXW, 5T0G, 7W3K, 7W3M, 7QXN, 7QXP, 5T0J, 6MSE, 8QYM, 8QYO, 8QYS, 8CVT, 5GJQ, 7QYB, 5L4G, 8CVR, 8TM5, 5LF3, 7B12, 5LEX, 5LF1, 5LF7, 7NAQ, 7NAP, 7LXV, 6REY, 8QYJ, 5VFO, 6AVO, 6WJD, 7V5M, 8QZ9, 5VFS, 6RGQ, 5VFP, 5VFQ, 6MSK, 7W3G, 7QXU, 5LN3, 7W3I, 6MSH, 4R3O, 7W38, 5GJR, 7NAN, 7W39, 5T0H, 7W3F, 5T0I, 8BZL, 6MSD, 7W3C, 7QXX, 7QY7, 7V5G, 5T0C, 8QYN, 8QYL, 7PG9, 6KWY, 7QYA, 5LE5, 7NHT, 5LEZ, 5LF4, 5LEY, 4R67, 8TM4, 6R70, 7NAO, 5LF6, 8TM6, 8UD9, 5A0Q, 5LF0, 8CXB, 8TM3, 7AWE, 5VFU, 6E5B, 5VFT, 7W3J, 7W3H, 7W3B, 5VFR, 6MSJ, 7W3A, 6XMJ, 6MSB, 8CVS

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.952	21
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.908	12
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.85	9
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.845	10
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.837	9
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.788	9
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.788	9
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279)	0.788	8
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.788	8
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.738	6
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.728	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.725	9
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.725	7
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.725	6
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.564	2
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.564	3
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.527	4
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	4
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	4
UniProt:Q99460 PSMD1	4	PSMD1 [cytosol] (R-HSA-68786) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [extracellular region] (R-HSA-6806194)	0.527	2
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.527	4
UniProt:P25786-2 PSMA1			0.527	3
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.527	3
UniProt:P40306 PSMB10	3	PSMB10 [cytosol] (R-HSA-68741) pro-PSMB10 [cytosol] (R-HSA-9908123) PSMB10(1-39) [cytosol] (R-HSA-9908142)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	5
UniProt:Q5JS54 PSMG4	1	PSMG4 [cytosol] (R-HSA-9908036)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.527	2
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.527	2
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.508	2
UniProt:Q6S8E0 Q6S8E0			0.508	2

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