Reactome | REL [nucleoplasm]

REL [nucleoplasm]

Stable Identifier

R-HSA-1168585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proto-oncogene c-Rel, REL_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Activation of NF-kappaB in B cells (Homo sapiens)
        
        NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
        
        NF-kappaB p50,p65,c-Rel dimer [nucleoplasm] (Homo sapiens)
        
        NF-kappaB p50:c-Rel [nucleoplasm] (Homo sapiens)
        
        REL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04864 REL

Gene Names

REL

Chain

initiator methionine:1, chain:2-619

Reference Genes

BioGPS Gene:5966 REL

COSMIC (genes):REL REL

CTD Gene:5966 REL

dbSNP Gene:5966 REL

ENSEMBL:ENSG00000162924.15 REL

HGNC:9954 REL

KEGG Gene (Homo sapiens):5966 REL

Monarch:5966 REL

NCBI Gene:5966 REL

OMIM:164910 REL

UCSC:Q04864 REL

Reference Transcript

Other Identifiers

0004730390

0104050315

11736551_x_at

11750334_a_at

16880414

16880428

1856_at

206036_PM_s_at

206036_s_at

228812_PM_at

228812_at

235242_PM_at

235242_at

239486_PM_at

239486_at

2484359

2484360

2484364

2484365

2484368

2484372

2484374

2484375

2484376

2484377

2484378

2484379

2484380

2484381

2484382

2484383

2484388

2484390

2484392

2484393

2484395

2484397

41572_r_at

53578_at

57733_at

5966

69985_at

79007_r_at

8042144

80829_at

A_14_P115770

A_19_P00315755

A_19_P00807145

A_21_P0001863

A_23_P56938

A_32_P177685

GE61112

GE780381

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0007249

GO:0010605

GO:0010629

GO:0023052

GO:0032688

GO:0032991

GO:0034097

GO:0038061

GO:0043123

GO:0043226

GO:0045087

GO:0045893

GO:0045944

GO:0071159

GO:0098542

HMNXSV003024656

HMNXSV003030281

Hs.188751.0.A1_3p_at

Hs.58066.0.A1_3p_at

Hs.86671.0.A1_3p_at

ILMN_1766085

ILMN_2124064

PH_hs_0003218

PH_hs_0003732

TC02000348.hg

TC02003262.hg

TC02003263.hg

X75042_at

g4506472_3p_at

p21127

p9806

Participates

as a component of

NF-kappaB p50:c-Rel [nucleoplasm] (Homo sapiens)

Other forms of this molecule

REL [cytosol]

Inferred To

Rel [nucleoplasm] (Drosophila melanogaster)

Rel [nucleoplasm] (Mus musculus)

Dif [nucleoplasm] (Drosophila melanogaster)

Homologues of REL [nucleoplasm] (Drosophila melanogaster)

dl [nucleoplasm] (Drosophila melanogaster)

rel [nucleoplasm] (Xenopus tropicalis)

REL [nucleoplasm] (Bos taurus)

REL [nucleoplasm] (Canis familiaris)

REL [nucleoplasm] (Gallus gallus)

REL [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_002899.1, NP_001278675.1

OpenTargets

ENSG00000162924

GeneCards

Q04864

HPA

ENSG00000162924-REL

Ensembl

ENST00000295025, ENST00000394479, ENSG00000162924, ENSP00000295025, ENSP00000377989

PRO

Q04864

Pharos - Targets

Q04864

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.695	7
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA [nucleoplasm] (R-HSA-4656929) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.669	4
UniProt:Q16236 NFE2L2	12	p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) ub-NFE2L2 [cytosol] (R-HSA-9758077) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.625	5
UniProt:Q00653 NFKB2	6	monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500) NFKB2(1-900) [cytosol] (R-HSA-2677931) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) p-7S-p100 [cytosol] (R-HSA-5607629) NFKB2(1-454) [cytosol] (R-HSA-168144) NFKB2(1-454) [nucleoplasm] (R-HSA-177674)	0.564	3
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.564	2
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.556	3
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.556	3
UniProt:P98177 FOXO4	8	FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501)	0.556	3
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.556	3
UniProt:Q8NFF5 FLAD1	1	FLAD1 [cytosol] (R-HSA-196980)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q969S2 NEIL2	1	NEIL2 [nucleoplasm] (R-HSA-5649650)	0.556	3
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:P48065 SLC6A12	1	SLC6A12 [plasma membrane] (R-HSA-351969)	0.556	3
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [cytosol] (R-HSA-265276) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [cytosol] (R-HSA-429010) p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765)	0.556	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.556	3
UniProt:O94979 SEC31A	5	SEC31A(1-989)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9713475) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A [cytosol] (R-HSA-203983) SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.556	3
UniProt:Q9NQ94 A1CF	1	A1CF [nucleoplasm] (R-HSA-3211440)	0.556	3
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.556	3
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q9UBH0 IL36RN	1	IL36RN [extracellular region] (R-HSA-8940995)	0.556	3

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