Reactome | GSDMD(1-275) [cytosol]

GSDMD(1-275) [cytosol]

Stable Identifier

R-HSA-9647641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gasdermin-D(1-275), Gasdermin-D, N-terminal, GSDMD_HUMAN

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        Interleukin-1 family are secreted (Homo sapiens)
        
        GSDMD pore complex [plasma membrane] (Homo sapiens)
        
        GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
        
        GSDMD(1-275) [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 processing (Homo sapiens)
        
        Interleukin-1 family are secreted (Homo sapiens)
        
        GSDMD pore complex [plasma membrane] (Homo sapiens)
        
        GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
        
        GSDMD(1-275) [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Regulation of TLR by endogenous ligand (Homo sapiens)
      - HMGB1 release from cells (Homo sapiens)
        
        GSDMD pore complex [plasma membrane] (Homo sapiens)
        
        GSDMD oligomer:PIPs [plasma membrane] (Homo sapiens)
        
        GSDMD(1-275) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P57764 GSDMD

Gene Names

GSDMD, DFNA5L, GSDMDC1, FKSG10

Chain

chain:1-484, chain:1-275, chain:276-484

Reference Genes

BioGPS Gene:79792 GSDMD

COSMIC (genes):GSDMD GSDMD

CTD Gene:79792 GSDMD

dbSNP Gene:79792 GSDMD

ENSEMBL:ENSG00000104518 GSDMD

ENSEMBL:ENSG00000104518.11 GSDMD

ENSEMBL:ENSG00000278718.3 GSDMD

HGNC:25697 GSDMD

KEGG Gene (Homo sapiens):79792 GSDMD

Monarch:79792 GSDMD

NCBI Gene:79792 GSDMD

OMIM:617042 GSDMD

UCSC:P57764 GSDMD

Reference Transcript

Other Identifiers

11741138_a_at

17073370

218154_PM_at

218154_at

3119657

3119660

3119661

3119666

3119667

3119669

3119670

3119672

3119674

3119677

3119678

3119680

3119682

3119684

3119685

3119686

65139_at

65140_at

79792

8148642

A_14_P131372

A_14_P132308

A_23_P112103

GE61932

GO:0001786

GO:0002376

GO:0005215

GO:0005515

GO:0005546

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006954

GO:0008289

GO:0012501

GO:0016020

GO:0022829

GO:0031410

GO:0031668

GO:0032731

GO:0035580

GO:0042742

GO:0043226

GO:0045087

GO:0046931

GO:0050829

GO:0050830

GO:0051260

GO:0055085

GO:0061702

GO:0065003

GO:0070269

GO:0070273

GO:0070300

GO:0072559

GO:0098542

GO:1901612

GO:1904724

GO:1904813

HMNXSV003034638

HMNXSV003044886

ILMN_1665428

PH_hs_0006565

TC08000824.hg

g13376057_3p_at

Participates

as an input of

as a component of

as an output of

Other forms of this molecule

GSDMD [specific granule lumen]

GSDMD [tertiary granule lumen]

GSDMD [extracellular region]

GSDMD [ficolin-1-rich granule lumen]

GSDMD(88-484) [cytosol]

GSDMD(1-87) [cytosol]

GSDMD [cytosol]

GSDMD(276-484) [cytosol]

S-(2-succinyl)-C191-GSDMD [cytosol]

GSDMD(269-484) [cytosol]

GSDMD(1-268) [cytosol]

dithiocarb-C191-GSDMD(1-275) [cytosol]

Inferred To

GSDMD [cytosol] (Bos taurus)

GSDMD [cytosol] (Sus scrofa)

Gsdmd [cytosol] (Mus musculus)

Gsdmd [cytosol] (Rattus norvegicus)

GSDMD(1-275) [cytosol] (Canis familiaris)

GSDMD(1-275) [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001159709.1, NP_079012.3

OpenTargets

ENSG00000104518

GeneCards

P57764

HPA

ENSG00000104518-GSDMD

Ensembl

ENSG00000278718, ENSG00000104518, ENST00000262580, ENST00000615119, ENST00000631751, ENST00000526406, ENSP00000488012, ENSP00000433209, ENSP00000482096, ENSP00000262580

PRO

P57764

Pharos - Targets

P57764

PDB

6VFE, 5WQT, 6N9O, 6KN0, 5NH1, 6AO4

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.781	7
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.659	13
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(1-404) [cytosol] (R-HSA-448692)	0.591	4
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q86T24 KAISO			0.556	3
UniProt:Q86U10 ASPG	1	ASPG [cytosol] (R-HSA-6797634)	0.556	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q96NG5 ZNF558	1	ZNF558 [nucleoplasm] (R-HSA-1973893)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3

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