Reactome | COG4 [Golgi membrane]

COG4 [Golgi membrane]

Stable Identifier

R-HSA-6808722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG4 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG4 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG4 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG4 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG4 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG4 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H9E3 COG4

Gene Names

COG4

Chain

initiator methionine:, chain:2-785

Reference Genes

BioGPS Gene:25839 COG4

COSMIC (genes):COG4 COG4

CTD Gene:25839 COG4

dbSNP Gene:25839 COG4

ENSEMBL:ENSG00000103051 COG4

HGNC:18620 COG4

KEGG:hsa:25839 COG4

Monarch:25839 COG4

NCBI Gene:25839 COG4

OMIM:606976 COG4

UCSC:Q9H9E3 COG4

Reference Transcript

Other Identifiers

11717140_a_at

11717141_x_at

11747236_x_at

11754384_x_at

16827805

212189_PM_s_at

212189_s_at

25839

3697124

3697126

3697127

3697128

3697129

3697130

3697131

3697132

3697133

3697136

3697137

3697138

3697139

3697141

3697142

3697143

3697144

3697145

3697146

3697147

3697148

3697150

3697151

3697152

3697153

3697154

3697155

3697156

3697157

3697159

3697160

3697161

38718_at

8002381

A_23_P320717

A_33_P3257628

GE56246

GO:0000139

GO:0000301

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0006890

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0043226

GO:0070085

HMNXSV003043656

Hs.108779.0.S1_3p_s_at

ILMN_1703683

PH_hs_0023049

TC16001239.hg

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG4 [trans-Golgi network membrane]

Inferred To

cogc-4 [Golgi membrane] (Caenorhabditis elegans)

cog4 [Golgi membrane] (Dictyostelium discoideum)

cog4 [Golgi membrane] (Schizosaccharomyces pombe)

cog4 [Golgi membrane] (Xenopus tropicalis)

Cog4 [Golgi membrane] (Drosophila melanogaster)

Cog4 [Golgi membrane] (Mus musculus)

Cog4 [Golgi membrane] (Rattus norvegicus)

COG4 [Golgi membrane] (Bos taurus)

COG4 [Golgi membrane] (Canis familiaris)

COG4 [Golgi membrane] (Gallus gallus)

COG4 [Golgi membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSG00000103051, ENST00000482252, ENSP00000432802

OpenTargets

ENSG00000103051

GeneCards

COG4

PRO

Q9H9E3

Pharos - Targets

Q9H9E3

Orphanet

COG4

PDB

3HR0

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.674	10
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q9P031 CCDC59	1	CCDC59 [nucleoplasm] (R-HSA-5683813)	0.527	2
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	2