Reactome | PSMB8 [cytosol]

PSMB8 [cytosol]

Stable Identifier

R-HSA-68762

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Immunoproteasome subunit beta-5i, Proteasome subunit beta type 8, Proteasome subunit beta type 8 precursor, Proteasome component C13, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P28062 PSMB8

Gene Names

PSMB8, LMP7, PSMB5i, RING10, Y2

Chain

propeptide:1-72, chain:73-276

Reference Genes

BioGPS Gene:5696 PSMB8

COSMIC (genes):PSMB8 PSMB8

CTD Gene:5696 PSMB8

dbSNP Gene:5696 PSMB8

ENSEMBL:ENSG00000204264 PSMB8

HGNC:9545 PSMB8

KEGG:hsa:5696 PSMB8

Monarch:5696 PSMB8

NCBI Gene:5696 PSMB8

OMIM:177046 PSMB8

UCSC:P28062 PSMB8

Reference Transcript

Participates

as a component of

20S CP immunoproteasome inner ring [cytosol] (Homo sapiens)

Other forms of this molecule

pro-PSMB8 [cytosol]

PSMB8(1-72) [cytosol]

PSMB8 [nucleoplasm]

Inferred To

pbs-5 [cytosol] (Caenorhabditis elegans)

psmb8a [cytosol] (Danio rerio)

Prosbeta5R2 [cytosol] (Drosophila melanogaster)

PRE2 [cytosol] (Saccharomyces cerevisiae)

Homologues of PSMB8 [cytosol] (Drosophila melanogaster)

Psmb8 [cytosol] (Mus musculus)

Psmb8 [cytosol] (Rattus norvegicus)

PSMB8 [cytosol] (Canis familiaris)

PSMB8 [cytosol] (Plasmodium falciparum)

Prosbeta5R1 [cytosol] (Drosophila melanogaster)

psmB5 [cytosol] (Dictyostelium discoideum)

pts1 [cytosol] (Schizosaccharomyces pombe)

Prosbeta5 [cytosol] (Drosophila melanogaster)

bPSMB8 [cytosol] (Bos taurus)

Cross References

RefSeq

NP_683720.2, NP_004150.1

ZINC - World Drugs

PSB8_HUMAN

Guide to Pharmacology - Targets

2408

OpenTargets

ENSG00000204264

ENSEMBL

ENST00000421445, ENST00000457261, ENSP00000414770, ENSG00000230034, ENSP00000414731, ENST00000429645, ENSP00000412618, ENSP00000394155, ENSP00000364015, ENST00000438442, ENSG00000235715, ENSP00000372723, ENSP00000372725, ENSP00000397057, ENST00000455660, ENSP00000406797, ENSG00000204264, ENSP00000364016, ENST00000436627, ENST00000435978, ENST00000452573, ENST00000416134, ENSG00000236443, ENST00000441960, ENST00000416564, ENSG00000231631, ENSP00000404585, ENSG00000230669, ENST00000383236, ENST00000383238, ENST00000374882, ENSP00000392693, ENSG00000226201, ENSP00000402406, ENSP00000407539, ENSP00000408825, ENSG00000206298, ENST00000374881

ZINC - FDA approved

PSB8_HUMAN

ZINC - Substances

PSB8_HUMAN

ZINC target

P28062

PRO

P28062

GlyGen

P28062

PDB

5L5T, 5L5U, 6AVO, 7B12, 6E5B, 5L5V, 5L5O, 5L5F, 5L5A, 5L5Q, 5L5P, 7AWE, 5L5S, 5L5H, 5L5I, 5M2B, 5L5B, 5L5D, 5L5J, 5LTT, 5L5R, 5L5E

ZINC - Investigational

PSB8_HUMAN

GeneCards

PSMB8

HPA

ENSG00000204264-PSMB8

Pharos - Targets

P28062

Orphanet

PSMB8

ZINC - Predictions - Purchasable

PSB8_HUMAN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312)	0.643	7
UniProt:P27958-PRO_0000037573			0.581	4
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	3
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.527	2
UniProt:Q9H078 CLPB			0.527	2
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.527	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.483	2

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