Reactome | NAD+ [mitochondrial matrix]

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NAD+ [mitochondrial matrix] Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
consumedByEvent	[Reaction:R-PFA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Plasmodium falciparum [Reaction:R-CEL-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Caenorhabditis elegans [Reaction:R-DME-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Drosophila melanogaster [Reaction:R-GGA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Gallus gallus [Reaction:R-XTR-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Xenopus tropicalis [Reaction:R-SSC-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Sus scrofa [Reaction:R-BTA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Bos taurus [Reaction:R-CFA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Canis familiaris [Reaction:R-MMU-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Mus musculus [Reaction:R-HSA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Homo sapiens [Reaction:R-RNO-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Rattus norvegicus [Reaction:R-GGA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Gallus gallus [Reaction:R-GGA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Gallus gallus [Reaction:R-SSC-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Sus scrofa [Reaction:R-SSC-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Sus scrofa [Reaction:R-BTA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Bos taurus [Reaction:R-BTA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Bos taurus [Reaction:R-CFA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Canis familiaris [Reaction:R-CFA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Canis familiaris [Reaction:R-RNO-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Rattus norvegicus [Reaction:R-RNO-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Rattus norvegicus [Reaction:R-MMU-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Mus musculus [Reaction:R-MMU-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Mus musculus [Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Homo sapiens [Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Homo sapiens [Reaction:R-DRE-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Danio rerio [Reaction:R-DRE-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Danio rerio [Reaction:R-CEL-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Gallus gallus [Reaction:R-XTR-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-DRE-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Danio rerio [Reaction:R-SSC-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Sus scrofa [Reaction:R-BTA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Bos taurus [Reaction:R-CFA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Canis familiaris [Reaction:R-RNO-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-MMU-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Mus musculus [Reaction:R-DDI-9858589] DLD dimer dehydrogenates dihydrolipoyl - Dictyostelium discoideum [Reaction:R-CEL-9858589] DLD dimer dehydrogenates dihydrolipoyl - Caenorhabditis elegans [Reaction:R-DME-9858589] DLD dimer dehydrogenates dihydrolipoyl - Drosophila melanogaster [Reaction:R-GGA-9858589] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-XTR-9858589] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis [Reaction:R-DRE-9858589] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio [Reaction:R-SSC-9858589] DLD dimer dehydrogenates dihydrolipoyl - Sus scrofa [Reaction:R-BTA-9858589] DLD dimer dehydrogenates dihydrolipoyl - Bos taurus [Reaction:R-CFA-9858589] DLD dimer dehydrogenates dihydrolipoyl - Canis familiaris [Reaction:R-RNO-9858589] DLD dimer dehydrogenates dihydrolipoyl - Rattus norvegicus [Reaction:R-MMU-9858589] DLD dimer dehydrogenates dihydrolipoyl - Mus musculus [Reaction:R-HSA-9858589] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens [Reaction:R-HSA-9955518] SIRT5 desuccinylates CPS1 - Homo sapiens [Reaction:R-DRE-450971] NNT dimer transfers proton from NADPH to NAD+ - Danio rerio [Reaction:R-DDI-9861616] DLD dimer dehydrogenates dihydrolipoyl - Dictyostelium discoideum [Reaction:R-GGA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-PFA-450971] NNT dimer transfers proton from NADPH to NAD+ - Plasmodium falciparum [Reaction:R-PFA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Plasmodium falciparum [Reaction:R-SCE-9861616] DLD dimer dehydrogenates dihydrolipoyl - Saccharomyces cerevisiae [Reaction:R-SCE-9853499] DLD dimer dehydrogenates dihydrolipoyl - Saccharomyces cerevisiae [Reaction:R-SPO-9861616] DLD dimer dehydrogenates dihydrolipoyl - Schizosaccharomyces pombe [Reaction:R-SPO-9853499] DLD dimer dehydrogenates dihydrolipoyl - Schizosaccharomyces pombe [Reaction:R-GGA-450971] NNT dimer transfers proton from NADPH to NAD+ - Gallus gallus [Reaction:R-DDI-450971] NNT dimer transfers proton from NADPH to NAD+ - Dictyostelium discoideum [Reaction:R-DDI-9853499] DLD dimer dehydrogenates dihydrolipoyl - Dictyostelium discoideum [Reaction:R-CEL-450971] NNT dimer transfers proton from NADPH to NAD+ - Caenorhabditis elegans [Reaction:R-CEL-9861616] DLD dimer dehydrogenates dihydrolipoyl - Caenorhabditis elegans [Reaction:R-CEL-9853499] DLD dimer dehydrogenates dihydrolipoyl - Caenorhabditis elegans [Reaction:R-GGA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-XTR-450971] NNT dimer transfers proton from NADPH to NAD+ - Xenopus tropicalis [Reaction:R-XTR-9853499] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis [Reaction:R-DRE-9853499] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio [Reaction:R-BTA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Bos taurus [Reaction:R-CFA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Canis familiaris [Reaction:R-RNO-9853499] DLD dimer dehydrogenates dihydrolipoyl - Rattus norvegicus [Reaction:R-MMU-9853499] DLD dimer dehydrogenates dihydrolipoyl - Mus musculus [Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens [Reaction:R-SSC-9853499] DLD dimer dehydrogenates dihydrolipoyl - Sus scrofa [Reaction:R-DME-9853499] DLD dimer dehydrogenates dihydrolipoyl - Drosophila melanogaster [Reaction:R-DME-9861616] DLD dimer dehydrogenates dihydrolipoyl - Drosophila melanogaster [Reaction:R-XTR-9861616] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis [Reaction:R-SSC-9861616] DLD dimer dehydrogenates dihydrolipoyl - Sus scrofa [Reaction:R-BTA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Bos taurus [Reaction:R-CFA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Canis familiaris [Reaction:R-RNO-9861616] DLD dimer dehydrogenates dihydrolipoyl - Rattus norvegicus [Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens [Reaction:R-MMU-9861616] DLD dimer dehydrogenates dihydrolipoyl - Mus musculus [Reaction:R-DRE-9861616] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio [Reaction:R-BTA-450971] NNT dimer transfers proton from NADPH to NAD+ - Bos taurus [Reaction:R-CFA-450971] NNT dimer transfers proton from NADPH to NAD+ - Canis familiaris [Reaction:R-RNO-450971] NNT dimer transfers proton from NADPH to NAD+ - Rattus norvegicus [Reaction:R-PFA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Plasmodium falciparum [Reaction:R-DDI-9859172] DLD dimer dehydrogenates dihydrolipoyl - Dictyostelium discoideum [Reaction:R-CEL-9859172] DLD dimer dehydrogenates dihydrolipoyl - Caenorhabditis elegans [Reaction:R-DME-9859172] DLD dimer dehydrogenates dihydrolipoyl - Drosophila melanogaster [Reaction:R-GGA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-XTR-9859172] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis [Reaction:R-DRE-9859172] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio [Reaction:R-SSC-9859172] DLD dimer dehydrogenates dihydrolipoyl - Sus scrofa [Reaction:R-BTA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Bos taurus [Reaction:R-CFA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Canis familiaris [Reaction:R-RNO-9859172] DLD dimer dehydrogenates dihydrolipoyl - Rattus norvegicus [Reaction:R-MMU-9859172] DLD dimer dehydrogenates dihydrolipoyl - Mus musculus [Reaction:R-HSA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens [Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+ - Homo sapiens [Reaction:R-MMU-450971] NNT dimer transfers proton from NADPH to NAD+ - Mus musculus [Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Homo sapiens [Reaction:R-CEL-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Gallus gallus [Reaction:R-XTR-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-SSC-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Sus scrofa [Reaction:R-BTA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Bos taurus [Reaction:R-CFA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-RNO-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-MMU-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Mus musculus [Reaction:R-HSA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Homo sapiens [Reaction:R-CEL-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Gallus gallus [Reaction:R-XTR-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-SSC-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Sus scrofa [Reaction:R-BTA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Bos taurus [Reaction:R-CFA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-RNO-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-MMU-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Mus musculus [Reaction:R-HSA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Homo sapiens [Reaction:R-CEL-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Gallus gallus [Reaction:R-XTR-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-SSC-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Sus scrofa [Reaction:R-BTA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Bos taurus [Reaction:R-CFA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-RNO-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-MMU-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Mus musculus [Reaction:R-HSA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Homo sapiens [Reaction:R-DRE-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Danio rerio [Reaction:R-DRE-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Danio rerio [Reaction:R-DRE-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Danio rerio [Reaction:R-DRE-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Danio rerio [Reaction:R-DRE-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Danio rerio [Reaction:R-HSA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Homo sapiens [Reaction:R-MMU-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Mus musculus [Reaction:R-RNO-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-CFA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-BTA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Bos taurus [Reaction:R-SSC-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Sus scrofa [Reaction:R-XTR-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-GGA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Gallus gallus [Reaction:R-DME-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Drosophila melanogaster [Reaction:R-CEL-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-HSA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Homo sapiens [Reaction:R-MMU-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Mus musculus [Reaction:R-RNO-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-CFA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-BTA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Bos taurus [Reaction:R-SSC-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Sus scrofa [Reaction:R-XTR-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-GGA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Gallus gallus [Reaction:R-CEL-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-373024] isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ - Gallus gallus [Reaction:R-GGA-373047] malate + NAD+ <=> oxaloacetate + NADH + H+ - Gallus gallus [Reaction:R-GGA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Gallus gallus [Reaction:R-DRE-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Danio rerio [Reaction:R-SSC-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Sus scrofa [Reaction:R-BTA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Bos taurus [Reaction:R-CFA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Canis familiaris [Reaction:R-RNO-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Rattus norvegicus [Reaction:R-MMU-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Mus musculus [Reaction:R-HSA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Homo sapiens [Reaction:R-CEL-5688276] SIRT4 transfers ADPRib to GLUD - Caenorhabditis elegans [Reaction:R-DME-5688276] SIRT4 transfers ADPRib to GLUD - Drosophila melanogaster [Reaction:R-GGA-5688276] SIRT4 transfers ADPRib to GLUD - Gallus gallus [Reaction:R-XTR-5688276] SIRT4 transfers ADPRib to GLUD - Xenopus tropicalis [Reaction:R-DRE-5688276] SIRT4 transfers ADPRib to GLUD - Danio rerio [Reaction:R-SSC-5688276] SIRT4 transfers ADPRib to GLUD - Sus scrofa [Reaction:R-BTA-5688276] SIRT4 transfers ADPRib to GLUD - Bos taurus [Reaction:R-CFA-5688276] SIRT4 transfers ADPRib to GLUD - Canis familiaris [Reaction:R-RNO-5688276] SIRT4 transfers ADPRib to GLUD - Rattus norvegicus [Reaction:R-MMU-5688276] SIRT4 transfers ADPRib to GLUD - Mus musculus [Reaction:R-HSA-5688276] SIRT4 transfers ADPRib to GLUD - Homo sapiens [Reaction:R-SPO-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Schizosaccharomyces pombe [Reaction:R-XTR-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Xenopus tropicalis [Reaction:R-HSA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Homo sapiens [Reaction:R-DME-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Drosophila melanogaster [Reaction:R-GGA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Gallus gallus [Reaction:R-DRE-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Danio rerio [Reaction:R-SSC-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Sus scrofa [Reaction:R-BTA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Bos taurus [Reaction:R-CFA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Canis familiaris [Reaction:R-RNO-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Rattus norvegicus [Reaction:R-MMU-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Mus musculus [Reaction:R-SCE-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Saccharomyces cerevisiae [Reaction:R-SPO-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Schizosaccharomyces pombe [Reaction:R-DDI-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Dictyostelium discoideum [Reaction:R-CEL-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Caenorhabditis elegans [Reaction:R-DME-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Drosophila melanogaster [Reaction:R-GGA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Gallus gallus [Reaction:R-XTR-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Xenopus tropicalis [Reaction:R-DRE-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Danio rerio [Reaction:R-SSC-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Sus scrofa [Reaction:R-BTA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Bos taurus [Reaction:R-CFA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Canis familiaris [Reaction:R-RNO-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Rattus norvegicus [Reaction:R-MMU-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Mus musculus [Reaction:R-HSA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Homo sapiens [FailedReaction:R-HSA-9907572] Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT - Homo sapiens [Reaction:R-PFA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Plasmodium falciparum [Reaction:R-SCE-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Saccharomyces cerevisiae [Reaction:R-SPO-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Schizosaccharomyces pombe [Reaction:R-DDI-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Dictyostelium discoideum [Reaction:R-DME-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Drosophila melanogaster [Reaction:R-GGA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Gallus gallus [Reaction:R-XTR-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Xenopus tropicalis [Reaction:R-DRE-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Danio rerio [Reaction:R-SSC-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Sus scrofa [Reaction:R-BTA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Bos taurus [Reaction:R-CFA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Canis familiaris [Reaction:R-RNO-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Rattus norvegicus [Reaction:R-MMU-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Mus musculus [Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Homo sapiens [Reaction:R-DRE-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Danio rerio [Reaction:R-DRE-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Danio rerio [Reaction:R-SSC-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Sus scrofa [Reaction:R-SSC-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Sus scrofa [Reaction:R-BTA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Bos taurus [Reaction:R-BTA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Bos taurus [Reaction:R-CFA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Canis familiaris [Reaction:R-CFA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Canis familiaris [Reaction:R-RNO-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Rattus norvegicus [Reaction:R-RNO-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Rattus norvegicus [Reaction:R-MMU-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Mus musculus [Reaction:R-MMU-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Mus musculus [Reaction:R-HSA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Homo sapiens [Reaction:R-HSA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Homo sapiens [Reaction:R-GGA-70679] ALDH4A1 oxidises L-GluSS to Glu - Gallus gallus [Reaction:R-XTR-70679] ALDH4A1 oxidises L-GluSS to Glu - Xenopus tropicalis [Reaction:R-DRE-70679] ALDH4A1 oxidises L-GluSS to Glu - Danio rerio [Reaction:R-SSC-70679] ALDH4A1 oxidises L-GluSS to Glu - Sus scrofa [Reaction:R-BTA-70679] ALDH4A1 oxidises L-GluSS to Glu - Bos taurus [Reaction:R-CFA-70679] ALDH4A1 oxidises L-GluSS to Glu - Canis familiaris [Reaction:R-MMU-70679] ALDH4A1 oxidises L-GluSS to Glu - Mus musculus [Reaction:R-HSA-70679] ALDH4A1 oxidises L-GluSS to Glu - Homo sapiens [Reaction:R-RNO-70679] ALDH4A1 oxidises L-GluSS to Glu - Rattus norvegicus [Reaction:R-PFA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Plasmodium falciparum [Reaction:R-SCE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Saccharomyces cerevisiae [Reaction:R-SPO-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Schizosaccharomyces pombe [Reaction:R-DDI-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Dictyostelium discoideum [Reaction:R-CEL-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Caenorhabditis elegans [Reaction:R-DME-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Drosophila melanogaster [Reaction:R-GGA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Gallus gallus [Reaction:R-XTR-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Xenopus tropicalis [Reaction:R-SSC-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Sus scrofa [Reaction:R-BTA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Bos taurus [Reaction:R-CFA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Canis familiaris [Reaction:R-RNO-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Rattus norvegicus [Reaction:R-MMU-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Mus musculus [Reaction:R-HSA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Homo sapiens [Reaction:R-DRE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Danio rerio [Reaction:R-MMU-9955513] Sirt5 desuccinylates Cps1 - Mus musculus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 - Gallus gallus [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 - Sus scrofa [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 - Bos taurus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 - Rattus norvegicus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 - Mus musculus [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 - Homo sapiens [Reaction:R-DDI-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Gallus gallus [Reaction:R-XTR-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Danio rerio [Reaction:R-SSC-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Sus scrofa [Reaction:R-BTA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Bos taurus [Reaction:R-CFA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Canis familiaris [Reaction:R-RNO-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Mus musculus [Reaction:R-SCE-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Saccharomyces cerevisiae [Reaction:R-SPO-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Schizosaccharomyces pombe [Reaction:R-DDI-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Drosophila melanogaster [Reaction:R-DRE-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Danio rerio [Reaction:R-RNO-70967] IDH3 complex decarboxylates isocitrate - Rattus norvegicus [Reaction:R-CFA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Canis familiaris [Reaction:R-CFA-70967] IDH3 complex decarboxylates isocitrate - Canis familiaris [Reaction:R-BTA-70967] IDH3 complex decarboxylates isocitrate - Bos taurus [Reaction:R-BTA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Bos taurus [Reaction:R-DRE-70967] IDH3 complex decarboxylates isocitrate - Danio rerio [Reaction:R-DRE-9012268] ME2 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-DDI-6797955] ALDH7A1 oxidises BETALD to BET - Dictyostelium discoideum [Reaction:R-CEL-6797955] ALDH7A1 oxidises BETALD to BET - Caenorhabditis elegans [Reaction:R-DME-6797955] ALDH7A1 oxidises BETALD to BET - Drosophila melanogaster [Reaction:R-GGA-6797955] ALDH7A1 oxidises BETALD to BET - Gallus gallus [Reaction:R-XTR-6797955] ALDH7A1 oxidises BETALD to BET - Xenopus tropicalis [Reaction:R-DRE-6797955] ALDH7A1 oxidises BETALD to BET - Danio rerio [Reaction:R-SSC-6797955] ALDH7A1 oxidises BETALD to BET - Sus scrofa [Reaction:R-BTA-6797955] ALDH7A1 oxidises BETALD to BET - Bos taurus [Reaction:R-CFA-6797955] ALDH7A1 oxidises BETALD to BET - Canis familiaris [Reaction:R-RNO-6797955] ALDH7A1 oxidises BETALD to BET - Rattus norvegicus [Reaction:R-HSA-6797955] ALDH7A1 oxidises BETALD to BET - Homo sapiens [Reaction:R-MMU-6797955] ALDH7A1 oxidises BETALD to BET - Mus musculus [Reaction:R-GGA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Gallus gallus [Reaction:R-GGA-9012268] ME2 tetramer decarboxylates MAL to PYR - Gallus gallus [Reaction:R-PFA-70979] MDH2 dimer dehydrogenates MAL - Plasmodium falciparum [Reaction:R-SCE-70967] IDH3 complex decarboxylates isocitrate - Saccharomyces cerevisiae [Reaction:R-SCE-70979] MDH2 dimer dehydrogenates MAL - Saccharomyces cerevisiae [Reaction:R-SPO-70979] MDH2 dimer dehydrogenates MAL - Schizosaccharomyces pombe [Reaction:R-SPO-70967] IDH3 complex decarboxylates isocitrate - Schizosaccharomyces pombe [Reaction:R-DDI-70967] IDH3 complex decarboxylates isocitrate - Dictyostelium discoideum [Reaction:R-CEL-70967] IDH3 complex decarboxylates isocitrate - Caenorhabditis elegans [Reaction:R-CEL-9012268] ME2 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL - Caenorhabditis elegans [Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL - Gallus gallus [Reaction:R-SSC-70967] IDH3 complex decarboxylates isocitrate - Sus scrofa [Reaction:R-DME-9012268] ME2 tetramer decarboxylates MAL to PYR - Drosophila melanogaster [Reaction:R-DME-70967] IDH3 complex decarboxylates isocitrate - Drosophila melanogaster [Reaction:R-DME-70979] MDH2 dimer dehydrogenates MAL - Drosophila melanogaster [Reaction:R-DRE-70979] MDH2 dimer dehydrogenates MAL - Danio rerio [Reaction:R-XTR-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Xenopus tropicalis [Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL - Xenopus tropicalis [Reaction:R-XTR-9012268] ME2 tetramer decarboxylates MAL to PYR - Xenopus tropicalis [Reaction:R-SSC-9012268] ME2 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Sus scrofa [Reaction:R-SSC-70979] MDH2 dimer dehydrogenates MAL - Sus scrofa [Reaction:R-SCE-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Saccharomyces cerevisiae [Reaction:R-SPO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Schizosaccharomyces pombe [Reaction:R-CEL-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Caenorhabditis elegans [Reaction:R-DME-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Drosophila melanogaster [Reaction:R-GGA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Gallus gallus [Reaction:R-XTR-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Xenopus tropicalis [Reaction:R-SSC-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Sus scrofa [Reaction:R-BTA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Bos taurus [Reaction:R-CFA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Canis familiaris [Reaction:R-RNO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Rattus norvegicus [Reaction:R-MMU-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Mus musculus [Reaction:R-HSA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Homo sapiens [Reaction:R-DRE-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Danio rerio [Reaction:R-BTA-70979] MDH2 dimer dehydrogenates MAL - Bos taurus [Reaction:R-BTA-9012268] ME2 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR - Homo sapiens [Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL - Canis familiaris [Reaction:R-RNO-70979] MDH2 dimer dehydrogenates MAL - Rattus norvegicus [Reaction:R-RNO-9012268] ME2 tetramer decarboxylates MAL to PYR - Rattus norvegicus [Reaction:R-RNO-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Rattus norvegicus [Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Homo sapiens [Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Homo sapiens [Reaction:R-MMU-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Mus musculus [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL - Mus musculus [Reaction:R-MMU-70967] IDH3 complex decarboxylates isocitrate - Mus musculus [Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate - Homo sapiens [Reaction:R-DDI-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Gallus gallus [Reaction:R-XTR-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Danio rerio [Reaction:R-SSC-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Sus scrofa [Reaction:R-BTA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Bos taurus [Reaction:R-CFA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Canis familiaris [Reaction:R-RNO-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Mus musculus [Reaction:R-HSA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Homo sapiens [Reaction:R-DDI-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Gallus gallus [Reaction:R-XTR-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Danio rerio [Reaction:R-SSC-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Sus scrofa [Reaction:R-BTA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Bos taurus [Reaction:R-CFA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Canis familiaris [Reaction:R-RNO-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Mus musculus [Reaction:R-DDI-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Gallus gallus [Reaction:R-XTR-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Danio rerio [Reaction:R-SSC-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Sus scrofa [Reaction:R-BTA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Bos taurus [Reaction:R-CFA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Canis familiaris [Reaction:R-RNO-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Mus musculus [Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Homo sapiens [Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Homo sapiens [Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens [Reaction:R-MMU-9012268] ME2 tetramer decarboxylates MAL to PYR - Mus musculus [Reaction:R-DRE-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Danio rerio [Reaction:R-HSA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Homo sapiens [Reaction:R-MMU-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Mus musculus [Reaction:R-RNO-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-CFA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Canis familiaris [Reaction:R-BTA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Bos taurus [Reaction:R-SSC-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Sus scrofa [Reaction:R-XTR-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-GGA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Gallus gallus [Reaction:R-DME-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Drosophila melanogaster [Reaction:R-CEL-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-373177] pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ - Gallus gallus [Reaction:R-GGA-373042] 2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ - Gallus gallus [Reaction:R-SCE-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Saccharomyces cerevisiae [Reaction:R-SPO-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Schizosaccharomyces pombe [Reaction:R-DDI-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Dictyostelium discoideum [Reaction:R-CEL-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Caenorhabditis elegans [Reaction:R-DME-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Drosophila melanogaster [Reaction:R-XTR-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Xenopus tropicalis [Reaction:R-DRE-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Danio rerio [Reaction:R-SSC-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Sus scrofa [Reaction:R-BTA-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Bos taurus [Reaction:R-CFA-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Canis familiaris [Reaction:R-RNO-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Rattus norvegicus [Reaction:R-MMU-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Mus musculus [Reaction:R-HSA-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH - Homo sapiens [Reaction:R-SCE-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Saccharomyces cerevisiae [Reaction:R-SPO-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Schizosaccharomyces pombe [Reaction:R-DDI-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Dictyostelium discoideum [Reaction:R-CEL-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Caenorhabditis elegans [Reaction:R-DME-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Drosophila melanogaster [Reaction:R-GGA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Gallus gallus [Reaction:R-XTR-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Xenopus tropicalis [Reaction:R-DRE-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Danio rerio [Reaction:R-SSC-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Sus scrofa [Reaction:R-BTA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Bos taurus [Reaction:R-CFA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Canis familiaris [Reaction:R-RNO-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Rattus norvegicus [Reaction:R-MMU-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Mus musculus [Reaction:R-HSA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Homo sapiens [Reaction:R-GGA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Gallus gallus [Reaction:R-XTR-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Xenopus tropicalis [Reaction:R-DRE-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Danio rerio [Reaction:R-SSC-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Sus scrofa [Reaction:R-BTA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Bos taurus [Reaction:R-CFA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Canis familiaris [Reaction:R-MMU-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Mus musculus [Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Homo sapiens [Reaction:R-RNO-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Rattus norvegicus [Reaction:R-SCE-9856799] HFD1 oxidizes 4-HBz - Saccharomyces cerevisiae [Reaction:R-HSA-9856794] Unknown dehydrogenase oxidizes 4-HBz - Homo sapiens [Reaction:R-GGA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Gallus gallus [Reaction:R-XTR-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Xenopus tropicalis [Reaction:R-SSC-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Sus scrofa [Reaction:R-BTA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Bos taurus [Reaction:R-CFA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Canis familiaris [Reaction:R-RNO-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Rattus norvegicus [Reaction:R-MMU-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Mus musculus [Reaction:R-HSA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Homo sapiens [Reaction:R-DRE-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Danio rerio [Reaction:R-CEL-9861626] SIRT4 cleaves lipoyl from DLAT - Caenorhabditis elegans [Reaction:R-DME-9861626] SIRT4 cleaves lipoyl from DLAT - Drosophila melanogaster [Reaction:R-GGA-9861626] SIRT4 cleaves lipoyl from DLAT - Gallus gallus [Reaction:R-XTR-9861626] SIRT4 cleaves lipoyl from DLAT - Xenopus tropicalis [Reaction:R-SSC-9861626] SIRT4 cleaves lipoyl from DLAT - Sus scrofa [Reaction:R-BTA-9861626] SIRT4 cleaves lipoyl from DLAT - Bos taurus [Reaction:R-CFA-9861626] SIRT4 cleaves lipoyl from DLAT - Canis familiaris [Reaction:R-RNO-9861626] SIRT4 cleaves lipoyl from DLAT - Rattus norvegicus [Reaction:R-MMU-9861626] SIRT4 cleaves lipoyl from DLAT - Mus musculus [Reaction:R-HSA-9861626] SIRT4 cleaves lipoyl from DLAT - Homo sapiens [Reaction:R-DRE-9861626] SIRT4 cleaves lipoyl from DLAT - Danio rerio [BlackBoxEvent:R-HSA-109342] Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation - Homo sapiens [BlackBoxEvent:R-HSA-109339] Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation - Homo sapiens [BlackBoxEvent:R-HSA-109339] Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation - Homo sapiens [BlackBoxEvent:R-HSA-109339] Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation - Homo sapiens
created	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
crossReference	[DatabaseIdentifier:29361] COMPOUND:C00003
dbId	113526
displayName	NAD+ [mitochondrial matrix]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-517495] NAD(P)+ [mitochondrial matrix]
modified	[InstanceEdit:9654424] D'Eustachio, Peter, 2019-07-18
name	NAD+ NAD NAD(+) Nicotinamide adenine dinucleotide DPN Diphosphopyridine nucleotide NAD+
producedByEvent	[Reaction:R-CEL-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Caenorhabditis elegans [Reaction:R-DME-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Drosophila melanogaster [Reaction:R-GGA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Gallus gallus [Reaction:R-DRE-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Danio rerio [Reaction:R-SSC-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Sus scrofa [Reaction:R-BTA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Bos taurus [Reaction:R-CFA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Canis familiaris [Reaction:R-MMU-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Mus musculus [Reaction:R-HSA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Homo sapiens [Reaction:R-RNO-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Rattus norvegicus [Reaction:R-XTR-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Xenopus tropicalis [Reaction:R-DRE-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Danio rerio [Reaction:R-CFA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Canis familiaris [Reaction:R-DME-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Drosophila melanogaster [Reaction:R-GGA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Gallus gallus [Reaction:R-SSC-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Sus scrofa [Reaction:R-BTA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Bos taurus [Reaction:R-RNO-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Rattus norvegicus [Reaction:R-MMU-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Mus musculus [Reaction:R-DDI-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Dictyostelium discoideum [Reaction:R-CEL-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Caenorhabditis elegans [Reaction:R-DME-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Drosophila melanogaster [Reaction:R-GGA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Gallus gallus [Reaction:R-XTR-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Xenopus tropicalis [Reaction:R-DRE-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Danio rerio [Reaction:R-SSC-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Sus scrofa [Reaction:R-BTA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Bos taurus [Reaction:R-CFA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Canis familiaris [Reaction:R-RNO-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Rattus norvegicus [Reaction:R-MMU-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Mus musculus [Reaction:R-HSA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Homo sapiens [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Homo sapiens [Reaction:R-GGA-372422] oxaloacetate + NADH + H+ <=> malate + NAD+ - Gallus gallus [Reaction:R-SPO-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Schizosaccharomyces pombe [Reaction:R-DME-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Drosophila melanogaster [Reaction:R-GGA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Gallus gallus [Reaction:R-XTR-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Xenopus tropicalis [Reaction:R-DRE-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Danio rerio [Reaction:R-SSC-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Sus scrofa [Reaction:R-BTA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Bos taurus [Reaction:R-CFA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Canis familiaris [Reaction:R-RNO-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Rattus norvegicus [Reaction:R-MMU-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Mus musculus [Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Homo sapiens [Reaction:R-PFA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Plasmodium falciparum [Reaction:R-SCE-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Saccharomyces cerevisiae [Reaction:R-SPO-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Schizosaccharomyces pombe [Reaction:R-DDI-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Dictyostelium discoideum [Reaction:R-CEL-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Caenorhabditis elegans [Reaction:R-DME-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Drosophila melanogaster [Reaction:R-GGA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Gallus gallus [Reaction:R-XTR-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Xenopus tropicalis [Reaction:R-DRE-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Danio rerio [Reaction:R-SSC-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Sus scrofa [Reaction:R-BTA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Bos taurus [Reaction:R-CFA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Canis familiaris [Reaction:R-RNO-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Rattus norvegicus [Reaction:R-MMU-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Mus musculus [Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens [Reaction:R-CEL-6807826] LDHAL6B reduces PYR to LACT - Caenorhabditis elegans [Reaction:R-DME-6807826] LDHAL6B reduces PYR to LACT - Drosophila melanogaster [Reaction:R-GGA-6807826] LDHAL6B reduces PYR to LACT - Gallus gallus [Reaction:R-XTR-6807826] LDHAL6B reduces PYR to LACT - Xenopus tropicalis [Reaction:R-DRE-6807826] LDHAL6B reduces PYR to LACT - Danio rerio [Reaction:R-CFA-6807826] LDHAL6B reduces PYR to LACT - Canis familiaris [Reaction:R-RNO-6807826] LDHAL6B reduces PYR to LACT - Rattus norvegicus [Reaction:R-MMU-6807826] LDHAL6B reduces PYR to LACT - Mus musculus [Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT - Homo sapiens [Reaction:R-DDI-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Dictyostelium discoideum [Reaction:R-CEL-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Caenorhabditis elegans [Reaction:R-DME-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Drosophila melanogaster [Reaction:R-GGA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Gallus gallus [Reaction:R-XTR-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Xenopus tropicalis [Reaction:R-DRE-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Danio rerio [Reaction:R-SSC-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Sus scrofa [Reaction:R-BTA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Bos taurus [Reaction:R-CFA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Canis familiaris [Reaction:R-RNO-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Rattus norvegicus [Reaction:R-MMU-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Mus musculus [Reaction:R-HSA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Homo sapiens [Reaction:R-CEL-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Caenorhabditis elegans [Reaction:R-HSA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Homo sapiens [Reaction:R-MMU-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Mus musculus [Reaction:R-RNO-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Rattus norvegicus [Reaction:R-CFA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Canis familiaris [Reaction:R-BTA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Bos taurus [Reaction:R-SSC-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Sus scrofa [Reaction:R-XTR-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Xenopus tropicalis [Reaction:R-GGA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA - Gallus gallus [Reaction:R-SCE-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Saccharomyces cerevisiae [Reaction:R-SPO-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Schizosaccharomyces pombe [Reaction:R-DDI-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Dictyostelium discoideum [Reaction:R-DME-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Drosophila melanogaster [Reaction:R-GGA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Gallus gallus [Reaction:R-XTR-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Xenopus tropicalis [Reaction:R-DRE-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Danio rerio [Reaction:R-SSC-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Sus scrofa [Reaction:R-BTA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Bos taurus [Reaction:R-CFA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Canis familiaris [Reaction:R-RNO-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Rattus norvegicus [Reaction:R-MMU-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Mus musculus [Reaction:R-HSA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:57540] NAD(1-) [ChEBI:57540]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-113526
updateTrackers	[UpdateTracker:9900763] Update Tracker - [SimpleEntity:113526] NAD+ [mitochondrial matrix] - v70:[add_removeReferenceEntity] [UpdateTracker:9890472] Update Tracker - [SimpleEntity:113526] NAD+ [mitochondrial matrix] - v52:[addName]

Referrals

(input)	[Reaction:R-GGA-373177] pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ [Reaction:R-GGA-373024] isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ [Reaction:R-GGA-373042] 2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ [Reaction:R-GGA-373047] malate + NAD+ <=> oxaloacetate + NADH + H+ [Reaction:R-GGA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-DRE-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-SSC-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-BTA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-CFA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-RNO-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-MMU-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-HSA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 [Reaction:R-CEL-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-DME-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-GGA-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-XTR-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-DRE-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-SSC-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-BTA-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-CFA-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-RNO-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-MMU-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-HSA-5688276] SIRT4 transfers ADPRib to GLUD [Reaction:R-SPO-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-XTR-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-HSA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-DME-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-GGA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-DRE-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-SSC-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-BTA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-CFA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-RNO-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-MMU-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ [Reaction:R-SCE-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-SPO-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-DDI-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-CEL-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-DME-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-GGA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-XTR-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-DRE-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-SSC-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-BTA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-CFA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-RNO-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-MMU-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [Reaction:R-HSA-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid [FailedReaction:R-HSA-9907572] Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT [Reaction:R-SCE-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-SPO-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-DDI-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-CEL-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-DME-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-XTR-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-DRE-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-SSC-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-BTA-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-CFA-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-RNO-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-MMU-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-HSA-5696091] ALDH1B1 tetramer oxidises CH3CHO to CH3COOH [Reaction:R-SCE-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-SPO-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-DDI-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-CEL-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-DME-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-GGA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-XTR-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-DRE-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-SSC-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-BTA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-CFA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-RNO-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-MMU-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-HSA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] [Reaction:R-PFA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-SCE-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-SPO-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-DDI-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-DME-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-GGA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-XTR-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-DRE-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-SSC-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-BTA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-CFA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-RNO-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-MMU-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF [Reaction:R-DRE-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-SSC-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-BTA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-CFA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-RNO-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-MMU-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-HSA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 [Reaction:R-PFA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-CEL-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-DME-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-GGA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-XTR-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-SSC-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-BTA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-CFA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-MMU-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-HSA-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-RNO-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ [Reaction:R-GGA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-XTR-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-DRE-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-SSC-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-BTA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-CFA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-MMU-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-RNO-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Reaction:R-GGA-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-XTR-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-DRE-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-SSC-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-BTA-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-CFA-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-MMU-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-HSA-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-RNO-70679] ALDH4A1 oxidises L-GluSS to Glu [Reaction:R-SCE-9856799] HFD1 oxidizes 4-HBz [Reaction:R-HSA-9856794] Unknown dehydrogenase oxidizes 4-HBz [Reaction:R-GGA-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-SSC-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-BTA-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-CFA-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-RNO-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-MMU-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-DRE-9854463] SIRT3 deacetylates AcK-IDH2 dimer [Reaction:R-PFA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-SCE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-SPO-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-DDI-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-CEL-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-DME-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-GGA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-XTR-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-SSC-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-BTA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-CFA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-RNO-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-MMU-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-HSA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-DRE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate [Reaction:R-GGA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-XTR-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-SSC-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-BTA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-CFA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-RNO-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-MMU-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-HSA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-DRE-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate [Reaction:R-CEL-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-DME-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-GGA-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-XTR-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-SSC-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-BTA-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-CFA-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-RNO-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-MMU-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-HSA-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-DRE-9861626] SIRT4 cleaves lipoyl from DLAT [Reaction:R-CEL-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-GGA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-XTR-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-DRE-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-SSC-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-BTA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-CFA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-RNO-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-MMU-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-DDI-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CEL-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DME-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-GGA-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-XTR-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DRE-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SSC-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-BTA-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CFA-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-RNO-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-MMU-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-HSA-9858589] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-MMU-9955513] Sirt5 desuccinylates Cps1 [Reaction:R-HSA-9955518] SIRT5 desuccinylates CPS1 [Reaction:R-GGA-9955504] SIRT5 deglutarylates CPS1 [Reaction:R-SSC-9955504] SIRT5 deglutarylates CPS1 [Reaction:R-BTA-9955504] SIRT5 deglutarylates CPS1 [Reaction:R-RNO-9955504] SIRT5 deglutarylates CPS1 [Reaction:R-MMU-9955504] SIRT5 deglutarylates CPS1 [Reaction:R-HSA-9955504] SIRT5 deglutarylates CPS1 [Reaction:R-DDI-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-CEL-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-DME-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-GGA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-XTR-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-DRE-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-SSC-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-BTA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-CFA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-RNO-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-MMU-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-SCE-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-SPO-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-DDI-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-CEL-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-DME-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-DRE-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-RNO-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-CFA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-CFA-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-BTA-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-BTA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-DRE-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-DRE-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-DRE-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-DDI-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-CEL-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-DME-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-GGA-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-XTR-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-DRE-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-SSC-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-BTA-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-CFA-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-RNO-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-HSA-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-MMU-6797955] ALDH7A1 oxidises BETALD to BET [Reaction:R-GGA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-DDI-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-GGA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-GGA-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-PFA-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-PFA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-PFA-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SCE-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SCE-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-SCE-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-SCE-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SPO-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SPO-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-SPO-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-SPO-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-GGA-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-DDI-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-DDI-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DDI-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-CEL-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-CEL-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-CEL-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-CEL-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CEL-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-GGA-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-XTR-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-XTR-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DRE-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-BTA-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CFA-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-RNO-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-MMU-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-HSA-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SSC-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SSC-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-DME-9853499] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DME-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-DME-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DME-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-DME-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-DRE-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-XTR-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-XTR-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-XTR-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SSC-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-BTA-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CFA-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-RNO-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-MMU-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SSC-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-SSC-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-DRE-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SCE-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-SPO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-CEL-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-DME-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-GGA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-XTR-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-SSC-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-BTA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-CFA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-RNO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-MMU-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-HSA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-DRE-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Reaction:R-BTA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-BTA-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-BTA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-CFA-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-RNO-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-RNO-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-RNO-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-RNO-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ [Reaction:R-MMU-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-MMU-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate [Reaction:R-DDI-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-CEL-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-DME-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-GGA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-XTR-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-DRE-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-SSC-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-BTA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-CFA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-RNO-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-MMU-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-HSA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Reaction:R-DDI-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-CEL-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-DME-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-GGA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-XTR-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-DRE-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-SSC-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-BTA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-CFA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-RNO-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-MMU-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-DDI-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-CEL-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-DME-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-GGA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-XTR-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-DRE-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-SSC-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-BTA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-CFA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-RNO-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-MMU-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-PFA-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DDI-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CEL-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DME-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-GGA-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-XTR-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-DRE-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-SSC-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-BTA-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-CFA-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-RNO-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-MMU-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-HSA-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-MMU-450971] NNT dimer transfers proton from NADPH to NAD+ [Reaction:R-MMU-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Reaction:R-CEL-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-GGA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-XTR-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-SSC-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-BTA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-CFA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-RNO-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-MMU-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-HSA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-CEL-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-GGA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-XTR-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-SSC-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-BTA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-CFA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-RNO-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-MMU-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-HSA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-CEL-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-GGA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-XTR-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-SSC-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-BTA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-CFA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-RNO-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-MMU-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-HSA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-DRE-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Reaction:R-DRE-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Reaction:R-DRE-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Reaction:R-DRE-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-DRE-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-DRE-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-HSA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-MMU-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-RNO-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-CFA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-BTA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-SSC-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-XTR-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-GGA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-DME-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-CEL-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Reaction:R-HSA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-MMU-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-RNO-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-CFA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-BTA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-SSC-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-XTR-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-GGA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-DME-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-CEL-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Reaction:R-HSA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-MMU-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-RNO-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-CFA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-BTA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-SSC-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-XTR-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-GGA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Reaction:R-CEL-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [BlackBoxEvent:R-HSA-109342] Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation [BlackBoxEvent:R-HSA-109339] Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation
(output)	[Reaction:R-GGA-372422] oxaloacetate + NADH + H+ <=> malate + NAD+ [Reaction:R-SPO-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-DME-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-GGA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-XTR-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-DRE-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-SSC-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-BTA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-CFA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-RNO-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-MMU-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Reaction:R-CEL-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-DME-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-GGA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-DRE-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-SSC-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-BTA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-CFA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-MMU-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-HSA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-RNO-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Reaction:R-SCE-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-SPO-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-DDI-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-DME-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-GGA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-XTR-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-DRE-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-SSC-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-BTA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-CFA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-RNO-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-MMU-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-HSA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Reaction:R-XTR-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-DRE-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-CFA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-DME-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-GGA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-SSC-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-BTA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-RNO-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-MMU-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-PFA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-SCE-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-SPO-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-DDI-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-CEL-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-DME-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-GGA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-XTR-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-DRE-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-SSC-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-BTA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-CFA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-RNO-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-MMU-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-CEL-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-DME-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-GGA-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-XTR-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-DRE-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-CFA-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-RNO-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-MMU-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT [Reaction:R-DDI-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-CEL-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-DME-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-GGA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-XTR-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-DRE-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-SSC-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-BTA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-CFA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-RNO-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-MMU-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-HSA-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ [Reaction:R-DDI-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-CEL-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-DME-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-GGA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-XTR-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-DRE-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-SSC-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-BTA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-CFA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-RNO-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-MMU-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-HSA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-CEL-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-HSA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-MMU-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-RNO-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-CFA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-BTA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-SSC-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-XTR-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA [Reaction:R-GGA-109343] Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA
(hasMember)	[DefinedSet:R-ALL-517495] NAD(P)+ [mitochondrial matrix]
(updatedInstance)	[UpdateTracker:9900763] Update Tracker - [SimpleEntity:113526] NAD+ [mitochondrial matrix] - v70:[add_removeReferenceEntity] [UpdateTracker:9890472] Update Tracker - [SimpleEntity:113526] NAD+ [mitochondrial matrix] - v52:[addName]

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