Reactome | (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H

Schema > Reaction > Entries

(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H Show undefined attributes

catalystActivity	[CatalystActivity:71061] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HADH dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667518] RHEA:31144 [DatabaseIdentifier:9977729] RHEA:31144
dbId	77323
displayName	(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H
eventOf	[Pathway:R-HSA-77350] Beta oxidation of hexanoyl-CoA to butanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77321] 3-Oxohexanoyl-CoA+CoA-SH => Butanoyl-CoA + acetyl-CoA - Homo sapiens [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Homo sapiens
input	[SimpleEntity:R-ALL-77322] (S)-Hydroxyhexanoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77409] Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H (3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + NADH + H(+)
orthologousEvent	[Reaction:R-DRE-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Danio rerio [Reaction:R-CEL-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-GGA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Gallus gallus [Reaction:R-XTR-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-SSC-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Sus scrofa [Reaction:R-BTA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Bos taurus [Reaction:R-CFA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-RNO-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-MMU-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Mus musculus
output	[SimpleEntity:R-ALL-77320] 3-Oxohexanoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77325] trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77323
summation	[Summation:178252] HADH in the mitochondrial matrix dehydrogenates (S)-3-hydrox...
updateTrackers	[UpdateTracker:9984733] Update Tracker - [Reaction:77323] (S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984733] Update Tracker - [Reaction:77323] (S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-77350] Beta oxidation of hexanoyl-CoA to butanoyl-CoA
(precedingEvent)	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-HSA-77321] 3-Oxohexanoyl-CoA+CoA-SH => Butanoyl-CoA + acetyl-CoA