Reactome | D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+

Schema > Reaction > Entries

D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ Show undefined attributes

catalystActivity	[CatalystActivity:74155] 3-hydroxybutyrate dehydrogenase activity of BDH1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77113] Gopinathrao, G, 2003-10-16 18:43:13
crossReference	[DatabaseIdentifier:12668377] RHEA:20522
dbId	73920
displayName	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+
eventOf	[Pathway:R-HSA-77108] Utilization of Ketone Bodies - Homo sapiens
followingEvent	[Reaction:R-HSA-74177] OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-73911] bHBA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200046] Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+
orthologousEvent	[Reaction:R-SPO-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Schizosaccharomyces pombe [Reaction:R-XTR-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Xenopus tropicalis [Reaction:R-DME-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Drosophila melanogaster [Reaction:R-GGA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Gallus gallus [Reaction:R-DRE-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Danio rerio [Reaction:R-SSC-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Sus scrofa [Reaction:R-BTA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Bos taurus [Reaction:R-CFA-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Canis familiaris [Reaction:R-RNO-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Rattus norvegicus [Reaction:R-MMU-73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - Mus musculus
output	[SimpleEntity:R-ALL-73909] ACA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73920
summation	[Summation:178628] D-beta-hydroxybutyrate dehydrogenase tetramer (BDH1) in the ...
updateTrackers	[UpdateTracker:9792356] Update Tracker - [Reaction:73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - v22:[addLiteratureReference] [UpdateTracker:9789290] Update Tracker - [Reaction:73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792356] Update Tracker - [Reaction:73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - v22:[addLiteratureReference] [UpdateTracker:9789290] Update Tracker - [Reaction:73920] D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ - v38:[modifyText]
(hasEvent)	[Pathway:R-HSA-77108] Utilization of Ketone Bodies
(precedingEvent)	[Reaction:R-HSA-74177] OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA
(reverseReaction)	[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+