Reactome | DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

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DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate Show undefined attributes

authored	[InstanceEdit:5694021] Jassal, Bijay, 2015-05-20
catalystActivity	[CatalystActivity:5694028] dihydrolipoyl dehydrogenase activity of OGDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5694021] Jassal, Bijay, 2015-05-20
dbId	5694018
displayName	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate
edited	[InstanceEdit:5694021] Jassal, Bijay, 2015-05-20
eventOf	[Pathway:R-HSA-6783984] Glycine degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-5693967] PXLP-K754-GLDC dimer decarboxylates Gly - Homo sapiens
input	[Complex:R-HSA-5693982] GCSH:DHLL [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70060] Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex [LiteratureReference:5694026] How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate
orthologousEvent	[Reaction:R-BTA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Bos taurus [Reaction:R-PFA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Plasmodium falciparum [Reaction:R-SCE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Saccharomyces cerevisiae [Reaction:R-SPO-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Schizosaccharomyces pombe [Reaction:R-DDI-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Dictyostelium discoideum [Reaction:R-CEL-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Caenorhabditis elegans [Reaction:R-DME-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Drosophila melanogaster [Reaction:R-GGA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Gallus gallus [Reaction:R-XTR-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Xenopus tropicalis [Reaction:R-DRE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Danio rerio [Reaction:R-SSC-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Sus scrofa [Reaction:R-CFA-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Canis familiaris [Reaction:R-RNO-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Rattus norvegicus [Reaction:R-MMU-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Mus musculus
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-6793611] Lipo-K107-GCSH [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5694018
summation	[Summation:5694019] The last step in the glycine cleavage system is the reoxidat...

Referrals

(hasEvent)	[Pathway:R-HSA-6783984] Glycine degradation
(precedingEvent)	[Reaction:R-HSA-5693967] PXLP-K754-GLDC dimer decarboxylates Gly

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