Reactome | alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

Schema > Reaction > Entries

alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10448989] L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity of ALDH7A1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10448991
displayName	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
eventOf	[Pathway:R-SSC-71064] Lysine catabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate - Sus scrofa
inferredFrom	[Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-113556] 2AMAS [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH
output	[SimpleEntity:R-ALL-508531] 2AMA [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Sus scrofa [Reaction:R-SSC-5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70941
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-SSC-70952] alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
(inferredTo)	[Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

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